Academy of Arts Education

Abstract Background Ozanimod (OZA) is approved for the treatment of adults with moderately to severely active (MOD/SEV) ulcerative colitis (UC) per results of the phase 3 True North trial. Real-world data are needed to determine treatment effects in a more diverse population in clinical practice. The COLIBRI study (NCT05382715) assesses the use, effectiveness, and safety of OZA and quality of life in patients (pts) with MOD/SEV UC in a routine clinical practice setting in Germany over a period of 52 or 104 weeks. This interim analysis of COLIBRI reports baseline (BL) characteristics and evaluates the symptomatic clinical effectiveness of OZA up to Week (W) 10. Methods COLIBRI will enrol up to 380 adults with UC; the study design is shown in the Figure. Adherence to the times of visits and the diagnostic and therapeutic measures are not mandatory and will correspond to the routine processes of the respective facilities. Partial Mayo score (pMS; sum of stool frequency subscore [SFS], rectal bleeding subscore [RBS], and Physician Global Assessment), symptomatic clinical improvement, defined as either symptomatic response (decrease from BL in the combined 6-point SFS + RBS of ≥1 point and >30%, and decrease of ≥1 point in RBS or absolute RBS of ≤1 point) or symptomatic remission (RBS = 0 and SFS ≤1, and a decrease of ≥1 point from BL SFS), and symptomatic remission were assessed at W4 and W10. Data were collected by electronic case report forms and by the study-specific interface of the MyTARGET app (Kiel, Germany) for pt-related outcomes, which were evaluated throughout the study. Results Of 83 pts included in this interim analysis (BL and W4, n=58; BL and W10, n=39), the median (interquartile range) age of pts was 40 (29.0–53.0) years, 49 (59.0%) were female and 34 (41.0%) male, 80.7% had prior exposure to advanced therapies (AT), and 48.2% had prior exposure to ≥3 AT. Overall, 67.5% had prior tumor necrosis factor alpha inhibitor and 50.6% had prior vedolizumab use. BL pt characteristics are shown in the Table. In total, 76 pts with BL data had pMS data; the mean (SD) pMS at BL was 5.0 (2.2), and most pts fell within the moderate pMS category (44.9%). Mean (SD) pMS decreased from BL (5.0 [2.2]) to 3.9 (2.6) at W4 and to 3.5 (2.3) at W10. Symptomatic clinical improvement was achieved in 32.8% (19/58) and 51.3% (20/39) of pts at W4 and W10, respectively. Symptomatic remission was achieved in 22.4% (13/58) and 25.6% (10/39) of pts at W4 and W10, respectively. Conclusion This interim analysis of the German COLIBRI study showed that refractory pts with MOD/SEV UC receiving OZA achieved symptomatic effectiveness at W4 and W10 in a routine clinical practice setting.

The discourse surrounding the theory and practice on migration in arts education in Germany is shaped by various terms and concepts. The German arts education manual references integration, cultural diversity or multiculturality, interculturality, polyculturality and transculturality (Keuchel S, Wagner E (2012) „Poly-, Inter-und Transkulturalitat“. In Bockhorst H, Reinwand V-I, Zacharias W (eds) Handbuch Kulturelle Bildung. kopaed, Munchen, 252pp, 2012), while more recent discourse has seen the terms post-migration or diversity appear. A content analytical study will therefore be carried out using selected texts to examine which arts education actors from politics and practice, science and associations use which of these concepts and which imperatives are associated with the respective concepts, especially in the field of culture education and arts.

The paper deals with the importance of common theoretical positions for cooperation between political forces. Intended is a critique on the idea that mere shared interests are a sufficient foundation for such efforts. Discrepancies between partial interests and a wider orientation are discussed in reference to Rosa Luxemburg and Anton Pannekoek.

AuszugJedes Spiel ist eine eigene erfundene Welt, mit bestimmten Regeln, Personen und Handlungen. Dabei ist es egal, ob es sich um ein Brettspiel, ein Rollenspiel, ein Computerspiel oder das Spiel mit Puppen und Bauklötzen handelt. Spiel ist "so tun als ob", d. h. im Spiel wird eine eigene Wirklichkeit in den Gedanken und Handlungen der Spielenden konstruiert. Und annehmen und sich ausdenken kann man alles bis zu den Grenzen der Fantasie. Das Spiel ist der große Freiraum zum Experimentieren, zum Erproben, zum Ausleben, zum Erholen von den Begrenzungen der alltäglichen Realität. Im Spiel kann man schalten und walten, wie man mit den fiktiven Symbolen aus der Realität will. Diese Freiheit gibt es sonst nur noch in der literarischen und audiovisuellen Fiktion, im Traum und in der Meditation, dort jedoch nicht aktiv beeinflussbar und nicht selbst bestimmbar.