Advanced Fiber Resources (China)

Abstract As a new type of underwater unmanned observation platform, autonomous underwater gliders (AUGs) play an important role in ocean exploration and marine environment monitoring. However, because of the dynamic and unpredictable marine environment, AUGs are often subjected to multiple disturbances, such as ocean currents, turbulence, and waves, which pose a substantial challenge to their precise attitude control. Therefore, research on a multisource disturbance rejection control algorithm for AUGs is crucial to improve their control accuracy. In this paper, first, based on the dynamic principle, a lightweight motion model of an AUG is established. Second, utilizing a multisource disturbance rejection control algorithm, a control scheme based on disturbance observer-based control (DOBC) and the $$H_{\infty}$$ H ∞ control law and a hybrid controller combining DOBC and the proportional-integral-derivative (PID) control algorithm are designed for the pitch angle control of AUG. The controllers are used to track the target attitude of the AUG, and the stability of the whole system is analyzed. Finally, the performance of the proposed algorithms is tested through simulation experiments, and their effectiveness and disturbance rejection performance are verified through comparison with the PID controller under the impact of various disturbances.

Thin-film lithium niobate (TFLN) has rapidly emerged as a highly competitive integrated photonic platform in fields such as data communication, microwave photonics, and quantum information processing. However, as a critical interface for chip-fiber links, the TFLN edge coupler is limited by its mode field diameter, exhibiting extremely low assembly tolerance when coupling with a standard single-mode fiber (SSMF), which severely restricts its application. Here, we propose a TFLN edge coupler based on a silicon nitride trident structure. By converting the small mode field of the lithium niobate waveguide into the large mode field of the Si3N4 trident structure, a high-efficiency, high-tolerance, and process-compatible edge coupler is constructed. Three-dimensional simulation results show that the device exhibits a mode field diameter greater than 8 μm, with TE mode coupling loss less than 0.71 dB, TM mode coupling loss less than 0.91 dB in the C+L band, and polarization-dependent loss below 0.41 dB. This device provides a promising solution to the challenge of high-performance, high-tolerance interconnection between TFLN chips and SSMFs.

Triple-negative breast cancer (TNBC), one of the most aggressive types of breast cancer, currently lacks a targeted therapy and has a high clinical recurrence rate. The present study reports an engineered magnetic nanodrug based on Fe3 O4 vortex nanorods coated with a macrophage membrane loaded with doxorubicin (DOX) and Enhancer of zeste 2 polycomb repressive complex 2 subunit (EZH2) siRNA. This novel nanodrug displays excellent tissue penetration and preferential tumor accumulation. More importantly, it significantly increases tumor suppression compared to chemotherapy, suggesting the synergistic activity of the combination of doxorubicin and EZH2-inhibition. Importantly, owing to tumor-targeted delivery, nanomedicine shows an excellent safety profile after systemic delivery, unlike conventional chemotherapy. In summary, chemotherapy and gene therapy are combined into a novel magnetic nanodrug carrying doxorubicin and EZH2 siRNA, which shows promising clinical application potential in TNBC therapy.