Al Furat University

Nanotechnology has emerged as a transformative approach to enhancing the concrete properties. This research examines the impact of nano-titanium dioxide (NT) on the concrete properties. NT was incorporated in varying dosages (0.5%, 1%, and 1.5% by weight of the cement) to assess its impact on strength, toughness, and resilience. The results demonstrated a significant enhancement in mechanical properties, with a peak compressive strength of 65.20 ± 1.03 MPa, a split tensile strength of 3.44 ± 0.17 MPa, and a flexural strength of 9.5 ± 0.47 MPa at a 1.5% NT dosage after 28 days of curing. Furthermore, the long-term performance was notable, as the compressive strength further increased to 75.25 ± 1.10 MPa at 180 days, confirming the sustained strength-gain potential of NT-incorporated concrete. Also, durability assessments were conducted under aggressive conditions, including exposure to 4% NaCl, HCl, and H2SO4 for 90 days. Additional tests, including rapid chloride penetrability test (RCPT), surface resistivity, freeze-thaw resistance, and accelerated carbonation, were conducted to assess long-term durability along with its economic feasibility. The NT-incorporated concrete demonstrated enhanced resistance to chloride ingress, acid attack, and elevated temperatures (200–600 °C), with improved modulus of elasticity and fire resistance. Furthermore, durability assessments revealed a noteworthy contrast, i.e., while resistivity tests classified NT-incorporated concretes as having ‘very low’ chloride penetrability, RCPT values remained in the ‘moderate’ category. This divergence underscores the need for multiple durability indices in evaluating nano-concretes. Microstructural analyses using scanning electron microscopy confirmed the densification effect of NT, leading to a refined pore structure and improved bond efficiency within the cementitious matrix. Moreover, economic analysis confirms the economic viability of nano-titanium concrete, demonstrating significant long-term savings through service life extension despite higher initial investment. This research highlights the potential of NT in developing high-performance, durable concrete, reinforcing the importance of nanotechnology in construction industry.Supplementary InformationThe online version contains supplementary material available at 10.1038/s41598-025-22974-4.

The prostaglandins inside inflamed tissues are produced by cyclooxygenase-2 (COX-2), making it an important target for improving anti-inflammatory medications over a long period. Adverse effects have been related to the traditional usage of non-steroidal anti-inflammatory drugs (NSAIDs) for the treatment of inflammation, mainly centered around gastrointestinal (GI) complications. The current research involves the creation of a virtual library of innovative molecules showing similar drug properties via a structure-based drug design. A library that includes five novel derivatives of Diclofenac was designed. Subsequently, molecular docking through the Glide module and determining the binding free energy implementing the Prime-MMGBSA module by the Schrödinger software package was used to identify compounds that showed marked specificity towards the COX-2 isoform. In addition, the ligands are subject to evaluation of their drug-like properties and ADMET (absorption, distribution, metabolism, excretion, and toxicity) characteristics using the QikProp module. Finally, molecular dynamics simulation has been calculated for the best molecule. The docking results indicated that all compounds own a predictive capability for specific binding to the COX-2 enzyme compared to the standard drug with a docking score range from -10.07 to -10.66 Kcal/mole, thus potentially overcoming the limitations imposed previously by the drugs currently used in clinical use. The ADMET analysis of the virtually active compounds demonstrated an acceptable drug-like profile and desirable pharmacokinetics properties. MM/GBSA calculation revealed that all the suggested compounds exhibited favorable free binding energies (-49.150 to - 60.185 Kcal/mole), indicating their strong potential to fit well into the COX-2 receptor. Finally, the MD simulation study revealed that compound 1 had perfect alignment with COX-2 receptor. The findings indicated that the compounds possess a predictive capability for specific binding to the COX-2 enzyme, thus potentially surmounting the restrictions imposed by the drugs currently employed in clinical use.

Background: Adaptive governance methods have become critical for organizational resilience and sustainability in today's turbulent and disruptive market settings. This article examines the important issue of altering governance systems to effectively deal with disruptive market dynamics. Objective: The article aims to look into how adaptive governance might increase an organization's competitiveness and agility in the face of rapid market changes. Methodology: This study applies a mixed-methods approach, investigating multiple case studies of organizations from various industries. The study looks at how adaptive governance frameworks are implemented, namely their structures, procedures, and decision-making mechanisms. In-depth information is acquired utilizing both qualitative and quantitative data collection techniques, such as surveys, interviews, and performance indicators. Results: The results highlight the importance of adaptive governance in fostering flexibility, innovation, and responsiveness in organizational contexts. This study uses case studies to demonstrate the association between greater resilience to market changes and adaptive governance approaches. It focuses on critical components of effective adaptive governance, such as strategic flexibility, inclusive decision-making, and iterative learning procedures.Conclusion: The article emphasizes the need of adaptive governance as a key strategy for organizations dealing with fluctuating market situations. Implementing adaptive governance structures allows organizations to preserve long-term competitiveness, encourage innovation, and respond proactively to market uncertainty. The study provides useful insights for professionals and decision-makers, underlining the necessity of adaptable governance in developing organizational resilience and future-proofing measures in the face of volatile market conditions.

مرت السيميائية بوصفها منهجًا لقراءة مختلف أنواع الخطاب بمرحلتين: مرحلة الحداثة (العمل)، ومرحلة ما بعد الحداثة (المشاريع)، وكثرت الدراسات التطبيقية لسيمياء العمل، ولم تكن كذلك لمرحلة المشاريع إلّا في جانب دراسة الأهواء، أما سيمياء الذات وسيمياء التوتّر فقلّما نجد لهما مقاربات تطبيقية. ولمشروع سيمياء الذات - كما جاء على يد جان كلود كوكي Jean Claude Coquet – برامجه وإجراءاته التي تدرس الذات المتلفظة، والذات الإدراكية، والذات الحاضرة، والذات الغائبة، وشبه الذات، من خلال تبيان كفاءتها واستقراء جهاتها (القدرة، المعرفة، الإرادة، الرغبة، الواجب)، واستجلاء القوانين السيميائية التي تتحكم بها في سياقَي اتّصالها وانفصالها عن موضوعها. ويسعى هذا البحث إلى مقاربة الذات في شعر سعاد الكواري مقاربة سيميائية؛ إذ إنّها تشكّل بؤرة مركزية تشعّ منها إبداعاتها الشعريّة وتدور في فلكها، الأمر الذي جعلها موضع عناية هذه الدراسة التطبيقية التي تعتمد المنهج السيميائي في معطياته ما بعد الحداثية.

El-Mukhlef, A.A., Sh.A. Kharouf and A. Al-Khalaf. 2023. Effect of Temperature on Efficacy of the Entomopathogenic Fungi Beauveria bassiana and Metarhizum anisopliae Against the Sunn Pest, Eurygaster integriceps Puton. Arab Journal of Plant Protection, 41(2): 134-139. https://doi.org/10.22268/AJPP-41.2.134139 An experiment was conducted in the plant protection laboratory of the Directorate of Agriculture and Agrarian Reform in Raqqa Province during 2013, to assess the effect of temperature and four spores suspension concentrations (1.5×102 , 103 , 104 and 105 spores/insect) on the efficacy of Beauveria bassiana and Metarhizum anisopliae against the Sunn pest (Eurygaster inegriceps Puton). Insect adults dorsal side were inoculated with 1.5×103 spores/insect of B. bassiana and caused insects mortality at a temperature range of 22-31°C, with optimum effect at 25°C, with a LT50 of 5.3 days after inoculation. In contrast, M. anisopliae had a wider temperature range up to 37°C, with optimal effect at 28- 31°C with LT50 of 5 days. No significant differences were observed between the fungal concentrations of 1.5×103 and 1.5×105 . Results obtained for using the four fungal spore suspension concentrations (1.5×102 , 1.5×103 , 1.5×104 , 1.5×105 spores/insect) under optimum conditions for each fungus indicated that the LT50 was close among concentrations, whereas, there was significant difference between the fungal two concentrations 1.5×102 and 1.5×104 , and B. bassiana was most effective at 1.5×104 spores/insect, in contrast to M. anisopliae which was most effective at 1.5×102 spores/insect. Keywords: Beauveria bassiana, Metarhizum anisopliae, Eurygaster inegriceps, Sunn Pest, biological control.

GFP is a 238 amino acid ~27 kDa protein derived from the crystal jellyfish Aequorea Victoria. was used to produce transgenic chickens, transgene expression was primarily in the pancreas and to a lesser extent in the liver, skin, muscles, and intestinal lining. The study describes the expression of GFP in various tissues from fetal, neonatal and adult animals. GFP expression in brain, lung, liver, and islet tissues was limited early in development, but was consistently strong in exocrine pancreas, kidney, cardiac, and skeletal muscle. The CAG promoter, which was hypothesized to induce ubiquitous protein expression, may be responsible for the differences in expression.

Актуальность исследования состоит в обеспечении малых габаритных размеров и массы редукторов, что позволяет размещать их вместе с поршневыми насосами в труднодоступных местах и экстремальных условиях при добыче высоковязкой нефти. Отношение массы редуктора к номинальному моменту на выходном валу является основным критерием технического уровня редукторов, поэтому необходимость создания новых видов механических передач с малыми габаритами и массой является актуальной. Цель: определить передаточное отношение волнового торцевого кинематического редуктора и зависимости объема блока шестерен и его угловой скорости от угла нутации . Объекты: волновой торцевой кинематический редуктор, который является неотъемлемой частью поршневых насосов при добыче высоковязкой нефти в экстремальных условиях. Методы: метод Виллиса, аналитический метод, численные методы решения систем нелинейных уравнений, теория механизмов и машин и основная теория зубчатого зацепления. Результаты. Рассмотрена проблема создания волнового торцевого кинематического редуктора с малыми габаритами, что позволяет размещать его вместе с поршневыми насосами в труднодоступных местах и экстремальных условиях при добыче высоковязкой нефти. Были определены передаточное отношение редуктора двумя способами (методом Виллиса и аналитическом методом) и зависимость размеров блока шестерен от угла нутации , а также верхнее предельное значение угла нутации, при котором редуктор работает устойчиво. Важно отметить, что волновой торцевой кинематический редуктор не требует выполнения условий равенства межосевых расстояний, что расширяет область его оптимального конструирования. Кроме того, его кинематика не накладывает ограничений на выбор модулей пар зубчатых колес или шага расположения зубьев, что расширяет набор возможных соотношений чисел зубьев колес и диапазон передаточных отношений.

<p>On the one hand, Pb isotope data on 18–13 Myr volcanic rocks from the eastern part of the Tunka Valley yield age estimate of garnet-bearing source region in the viscous mantle of ca. 2.2 Byr that might correspond to the age of the Siberian craton mantle. On the other hand, inclusions from basanites show the pressure range that overlaps the pressure estimates for rocks of the Slyudyanka Ordovician collision zone. The lithospheric material corresponds to the transition from spinel-pyroxene to olivine-plagioclase facies of peridotites in the uppermost part of the mantle and lower-middle crust. V<sub>S</sub>-data show a low-speed zone dipping from the central Tunka valley eastwards under Southern Baikal to a depth of 70 km. This zone ends at the South Baikal – Tunka Valley junction. We suggest that the eastern parts of the Tunka Valley has inherited the Early Paleozoic collision zone between the Hamar-Daban Terrane and Siberian Paleo-Continent and that the lithosphere of the collision zone overlays the viscous mantle related to the Siberian craton.</p><p>This work is supported by the RSF grant 18-77-10027.</p>