Alcon (China)

PurposeTo compare and evaluate the clinical performance and fit success of lehfilcon A and lotrafilcon B multifocal soft contact lenses (MfSCLs).Patients and MethodsThis was a prospective, randomized, double-masked, crossover, dispensing clinical study. Eligible wearers were fitted and wore study MfSCLs bilaterally (≥8 hours/day, ≥5 days/week) over 30 days. Endpoints: binocular visual acuity (VA) at distance (4 m), intermediate (80 cm), and near (40 cm) at day 30; fit rate success; eye care professional (ECP) rating, study dispensed lens power at visit 1; lens fit, and surface characteristics at dispense and day 30; safety assessments.ResultsOverall, 101 subjects were enrolled. At day 30, lehfilcon A MfSCLs were noninferior to lotrafilcon B MfSCLs for distance, intermediate, and near VA (non-inferiority margin: 0.05; 95% UCL of LSM difference 0.00, 0.02, 0.04; mean VA, lehfilcon A: −0.10 ± 0.08, −0.10 ± 0.08, and 0.01 ± 0.12; lotrafilcon B: −0.09 ± 0.07, −0.11 ± 0.08, and −0.02 ± 0.11). At visit 1, ≥99.5% of both MfSCLs achieved successful fit with 1–2 lenses/eye. Mean ECP ratings for ease of fit: lehfilcon A 9.8 ± 0.6; lotrafilcon B: 9.7 ± 0.6. About 96.0% of subjects had same sphere (D) power and 100.0% had same ADD power in both eyes for both lenses. All MfSCLs had optimal/acceptable fit. Majority of MfSCLs (>96%) had grade 0/1 front surface wettability and front/back surface deposits. No serious AEs were reported, and all biomicroscopy findings were graded 2 (mild) or lower.ConclusionLehfilcon A multifocal contact lenses combine excellent visual performance, high fit success, and a stable, comfortable wearing experience over 30 days of daily wear. With their water-gradient surface, favorable safety profile, and ease of fit, they represent a reliable and beneficial option for clinicians to consider when selecting multifocal lenses for presbyopic patients.

PurposeThis 12-month, prospective, single-arm, postmarketing study assessed efficacy, safety, and patient satisfaction for AcrySof IQ PanOptix TFNT00 intraocular lens in a Chinese population.Patients and MethodsAdults with bilateral cataracts received TFNT00 (286 eyes); visual acuity (VA) was assessed at 12 months. Manifest refraction spherical equivalent (MRSE), corrected and uncorrected distance VA (CDVA, UDVA), distance-corrected and uncorrected intermediate (DCIVA, UIVA) and near (DCNVA, UNVA) VA, and defocus curve were evaluated. Patient-reported outcomes were assessed using questionnaires. Adverse events (AEs) were evaluated.Results134/144 patients (268/286 eyes) completed the study. At 12 months, MRSE was −0.06±0.36 D. Monocular and binocular CDVA ≤0.3 logMAR was achieved in 99.3% of patients. Mean±SD monocular CDVA, UDVA, DCIVA, UIVA, DCNVA, and UNVA were −0.01±0.13, 0.04±0.13, 0.076±0.14, 0.089±0.14, 0.084±0.13, and 0.096±0.13 logMAR, respectively. Binocular VA was equal to or better than 0.1 logMAR for defocus range +0.5 to −3.0 D. Most patients achieved spectacle independence for distance (94%), intermediate (90%), and near (87%) vision; 88% were “satisfied” or “very satisfied.” No device-related AEs were reported. Forty eyes (14%) had posterior capsular opacity (37 were clinically nonsignificant; 1 [0.4%] required posterior capsulotomy). Five cystoid macular edema cases (1.7%) were reported. Severe starbursts, halo, and glare were reported by 15.6%, 4.4%, and 2.3% of patients, respectively, with only 1.5% of patients significantly bothered by each.ConclusionTFNT00 was safe and effective in a Chinese population, providing good VA at far, intermediate, and near distances, with high rates of spectacle independence and patient satisfaction.

Close symptom monitoring can benefit patients with metastatic nonsmall cell lung cancer (mNSCLC) receiving first-line therapy. Remote patient monitoring technologies, like the artificial intelligence (AI)-enabled Kaiku® Health platform that allows oncology patients to report their health status in real-time to healthcare providers, may enhance patients' treatment experience. The lung artificial intelligence-enabled digital solution pilot study ("Lung AID") assessed the feasibility of future studies on Kaiku® Health in patients with mNSCLC receiving first-line pembrolizumab in Germany. Patient engagement with Kaiku® Health and practicality of collecting patient-reported outcomes (PROs) via the separate Lung AID EDC system were assessed by platform access rates. Kaiku® Health access required one login, while Lung AID EDC access required submission of ≥1 PRO questionnaire. Post hoc analyses explored access by site experience with Kaiku® Health. Over a 17-month enrollment period, 47 of 100 planned patients were enrolled in the study. Kaiku® Health was accessed by 85.1% of patients, with higher engagement at experienced sites (96.2%). Only 38.3% accessed the Lung AID EDC system; 31.9% used both systems. High Kaiku® Health access rates imply patient interest in remote digital monitoring for mNSCLC. However, recruitment challenges and use of a separate system to collect PRO data demonstrated difficulties in assessing the feasibility of these technologies in real-world settings. Our results highlight the need for streamlined patient monitoring tools and enhanced site and patient engagement strategies. While definitive conclusions on future studies cannot be drawn, the study offers key insights into challenges that should be considered in future research.

To compare surge volume after occlusion breaks in five phacoemulsification systems. A mechanical spring-eye model was used to evaluate the Legion™ Vision System with the Single Use Fluidics Management System (FMS) (LEG), Infiniti™ Vision System with Intrepid™ Plus FMS (INF), Whitestar Signature Pro® with the OPO73 pack (WSP), Compact Intuitiv® with the OPO80 pack (CIS), and Stellaris PC® with the StableChamber cassette (SPC). Transient occlusion break surge volume responses were assessed across a full range of system settings (IOP: 30 to 80mmHg; vacuum limit: 300 to 650mmHg; aspiration rate: 20 or 40 cc/min. Oscilloscope waveforms covered stable flow before occlusion, full occlusion, occlusion break, and full recovery to stable flow. Raw oscilloscope data were converted to volumetric and pressure measurements. Fitted average surge traces were generated for each test condition and used to develop an interpolation algorithm to predict transient occlusion break surge events. The minimum surge volume for all systems occurred at the highest IOP (80mmHg) and the lowest tested vacuum limit (300mmHg). Overall, the surge volume increased with increasing vacuum limit and decreasing IOP on the LEG, INF CIS, WSP, and SPC systems. The occlusion break surge volumes (µL [standard deviation]) at 60mmHg IOP and vacuum limit of 500mmHg were 70.4 [8.1] for LEG; 87.4 [9.7] for INF; 85.8 [7.2] for CIS; 69.5 [5.0] for WSP; and 151.7 [20.2]) for SPC. A Games-Howell post-hoc test showed significant differences between three groups: A) LEG/WSP, B) CIS/INF, and C) SPC. The Legion system demonstrated comparable or lower predicted surge volume after occlusion breaks compared to the other phacoemulsification systems evaluated. Reductions in occlusion break surge volumes are expected to decrease the rate of complications and lead to improved outcomes in the clinical cataract surgery setting.

Cataract surgery, a transformative procedure to restore vision, has seen remarkable advancements in intraocular lens (IOL) technologies. This special issue presents a collection of research that explores the performance, design, and evaluation of IOLs. From established designs and the impact of key optical parameters to innovative approaches and preoperative simulations, these contributions offer a comprehensive view of current trends and future directions in IOL development. The special issue also honors the legacy of Prof. Jim Schwiegerling whose contributions to visual optics in general, and IOLs in particular, have had a tremendous impact in the field, both in the academic, clinical and industrial communities.

Summary The main aim of the article is to look at petrophysical parameters of sandstones and siltstones of the Carboniferous period of the southern part of the Northern marginal zone of the Dnieper-Donetsk depression (the depth from 1109 to 4572 m) in normal (atmospheric) and modeling (reservoir) conditions. The studied area is promising for the presence of non-conventional hydrocarbon deposits (shale gas, gas of condensed rocks, etc.). Carboniferous tight terrigenous rocks are represented by low porosity sandstones and siltstones. In the Research laboratory of theoretical and applied geophysics of the Institute of Geology comprehensive petrophysical study was carried out, which included determination of: resistivity; the formation resistivity factor (F) and resistivity index (RI); porosity (ϕ) in atmospheric and reservoir conditions. The comprehensive analysis of petrophysical data has been resulted in a set of correlations between the porosity and the formation factor; the resistivity index and the water saturation, etc. The study subject was a collection of 71 samples of the terrigenous tight rocks.

Introducción: La Osteomielitis en pediatría es una infección ósea grave que requiere ser diagnosticada y tratada de manera oportuna por las altas tasas de secuelas y complicaciones. Las bacterias pueden llegar al hueso por inoculación directa a partir de heridas traumáticas, por diseminación desde tejidos adyacentes afectados por celulitis o artritis séptica, o por siembra hematógena con afectación de médula ósea, cortical, periostio o tejidos blandos circundantes. En los niños la infección ósea aguda suele ser de origen hematógeno. El S. aureus es el agente causal más frecuente. La osteomielitis puede ser aguda, subaguda o crónica. El objetivo es describir el abordaje y tratamiento de la osteomielitis de acuerdo a las características de presentación del paciente destacando el rol del equipo multidisciplinario. Caso clínico: Preescolar de 4 años, con antecedente de fractura oblicua de metáfisis de fémur izquierdo, con resolución quirúrgica con reducción incruenta + tutores externos + osteosíntesis con clavo intramedular de Rush, reingreso a la emergencia 2 meses después por cuadro clínico de 7 días de evolución caracterizado por edema, rubor, eritema, fiebre, e incapacidad para la marcha y bipedestación, secreción purulenta en sitio de ingreso de tutor externo. Hemocultivo reportó: S.aureus meticilino resistente (SAMR). Estancia hospitalaria: 67 días. Conclusión: En el presente paciente la resonancia magnética fue el estudio de imagen considerado útil para la detección y localización del proceso inflamatorio secundario a infección, por la alta sensibilidad y validez durante el periodo de seguimiento, evitando la exposición de radiación al paciente.

Kaiser, Stephanie M. BA; Bhatnagar, Anshul BA; Weng, Christina Y. MD, MBA Author Information

Subject and Purpose. The subject of investigation is a new class of resonant-type transmit antennas intended for operation at millimeter wavelengths. The model under consideration is based on the idea of diffractional re-emission of waves into the azimuthal direction by local inhomo-geneities of the basically cylindrical structure. The purpose of the work is to justify the possibility of using such an effect for creating antennas with a circular radiation pattern, and to suggest an appropriate design. Methods and Methodology. The research program included both experimental work and application of advanced computer simulation techniques. The modern methods employed have allowed studying electromagnetic field distributions both in internal domains of the dielectric resonators and in the far-field zones of the resonator-based antennas. Results. Design solutions have been proposed for resonant-type, omnidirectional transmit antennas to operate in the millimeter waveband. The characteristic parameters are sizes of their radiating elements, specifically the segmental members equidistantly disposed along the azimuthal direction on the cylindrical surfaces of dielectric disks. The radiational characteristics of such antennas, with segments of either localized or extended dimension (compared with the operating wavelength) have been investigated. Electric field intensity distributions in the far-field region and the respective gain factors of the antennas have been studied. Conclusions. The antennas based on segmental dielectric resonators have been shown to form multi-lobe radiation patterns covering the angular sector of 0–360 along the azimuth. By placing the local segments at the resonant field’s antinodes (of the operating mode) it is possible to achieve relatively high values of the gain, reaching 15.5 dB at the lobe maxima

This paper presents a multi-analytic study conducted as part of the IDHEA project at the former Tuna Factory "Florio," an architectural complex situated on the captivating island of Favignana within the Egadi Islands, Trapani, Sicily, Italy.As a 19thcentury industrial archaeology pole, this site stands as an intriguing nexus of architecture, museum exhibits, and cultural significance, rendering it an ideal experimental ground for pioneering methods and technologies aimed at preserving, managing, and enhancing cultural heritage.Given its coastal location, the structures are highly susceptible to marine, geomorphological, and environmental threats, intensifying material degradation risks.In this study, different approaches were adopted for the inspection, decay assessment and architectural survey of the building complex, including 3D architectural surveys via terrestrial laser scanning, drone-based RGB photogrammetry, multispectral data collection, and direct inspections.This integration yields comprehensive data and intricate 3D models, aiding in pinpointing specific vulnerabilities.The study culminates in the implementation of a GIS platform that harmonizes all data, serving as a pivotal resource for managing and preserving this historically significant site.