Alten (Italy)

Abstract Mit dem Zukunftsbild Digitaler Zwilling visioniert der Masterplan BIM Bundesfernstraßen des BMDV die digitale Repräsentation und Vernetzung aller bauwerksrelevanten Daten der realen Infrastruktur. Insbesondere für Brücken als neuralgische Bestandteile der Verkehrsinfrastruktur ermöglichen Digitale Zwillinge eine optimierte Zustandsbewertung. Die erfolgreiche Einbindung Digitaler Brückenzwillinge in das Erhaltungsmanagement erfordert standardisierte Konzepte für deren Entwicklung. Hier knüpft das vom BMDV geförderte Forschungsprojekt ANYTWIN mit dem Ziel an, messwertgestützte Tragsicherheitsnachweise in Digitale Brückenzwillinge einzubinden. Die Konzeptentwicklung umfasst eine umfangreiche, branchenübergreifende Recherche vorhandener Definitionen und Charakteristika. Es wurden reifegradabhängige Merkmale Digitaler Brückenzwillinge herausgearbeitet und deren Einfluss auf die messwertgestützte Nachweisführung untersucht. Abschließend wurden BPMN‐Prozessdiagramme als anschauliches Werkzeug verwendet, um den Einfluss jeweiliger Reifegrade auf Prozessebene zu beschreiben.

In the development of novel immunotherapeutic approaches, the step of target identification is a challenging process, because it aims at identifying robust tumor-associated antigens (TAAs) specific for the pathological population and causing no off-target effects. Here we propose CD72 as a novel and robust TAA for pediatric acute leukemias. We provided an outline of CD72 expression assessed by flow cytometry on a variety of cancer cell lines and primary samples, including normal bone marrow (BM) samples and hematopoietic stem and progenitor cells. We analyzed CD 72 expression on a cohort of 495 pathological pediatric BM aspirates, including: 215 B-cell precursor acute lymphoblastic leukemias (BCP-ALL), 156 acute myeloid leukemias (AMLs), 88 T-lineage ALLs or lymphoblastic lymphomas with BM infiltration, 13 B-lineage lymphoblastic lymphomas with BM infiltration, 9 myelodysplastic syndromes with increased blasts (5%-9% blasts on BM: MDS-IB1) and 14 non-hematopoietic solid tumors infiltrating BM. Results showed that CD72 is highly expressed in almost all BCP-ALL and the majority of AML at diagnosis, including BCP-ALL cases characterized by CD19 loss. These findings support a potential role for advanced diagnostics and novel immunotherapy approaches, providing a pan-ALL and AML target.

In antiken Zeugnissen wird häufig nach der Bestätigung der Gegenwart gesucht - so auch bei der Frage der Individualität. Das Alte Ägypten liefert jedoch keine Blaupause für die Moderne; vielmehr lässt sich durch die Suche nach dem Individuum in der Antike, hier genauer im Ägypten des 1. Jahrtausends vor der Zeitenwende erkennen, dass auch der moderne Mensch eher ein konfektioniertes „animal sociale“ ist als ein unabhängiges und eigenständiges Subjekt. Individualität besteht im spätzeitlichen Ägypten im Sinne eines persönlichen Geschmacks in der unterschiedlichen Auswahl und Kombination vorhandener Traditionen. Spätzeitliche Menschen stellen sich jedoch in Gräbern zumeist als stereotyp Gerechte dar, die ganz die Ausfüllung ihrer sozialen Rollen betonen. Aspekte, die auf individuelle Schicksale und Brüche hinweisen, werden dabei in Grabestexten stark heruntergespielt. Am deutlichsten greifbar wird dieses Personenverständnis durch das mit einem Kiebitz - einem geselligen Schwarmvogel - häufig determinierte äg. Wort für „Volk“ (reḫy.t), über dem der König von Ägypten als falkenartiger „lebender Horus“ schwebt. Individualität eignen sich in der Spätzeit Menschen etwa nicht durch Heraustreten aus dem Schwarm an, sondern - wie auf unzähligen Sargdeckeln zu sehen - durch die eigene Identifikation mit dem Falken, sprich durch die Imitation des Königs. Ein Jemand zu sein - im Diesseits oder Jenseits - ist wichtiger als die Darstellung eigener Individualität.

The Name Čech ‚Czech‘ This essay about the name Čech has been written in response to the explanation of this ethnonym in the latest Czech etymological dictionary by J. Rejzek. This author offers several possible explanations, but none of them seems to be convincing. The only one that might be correct is the derivation from a full name Česlav from Proto-Slavic *Čьstьslavъ, where the initial open syllable Če- was supplemented by the hypocoristic suffix -ch.

Pose estimation is critical for mobile robots to fulfill various tasks, such as path following or mapping the environment. This is usually accomplished by simultaneous localization and mapping (SLAM). However, computationally constrained systems, such as planetary rovers, rely on less intensive guidance navigation and control (GNC) solutions generally derived solely from visual odometry (VO), wheel odometry, and the onboard inertial measurement unit. Although providing adequate localization performances, the drift accumulated overtime is not compensated by loop closing capabilities, typical of SLAM. Usually, rovers send surface images to the ground station, and these images are used for multiple purposes, such as scientific and operational planning. The number of images is constrained by the communication bandwidth and power budget. The set of transmitted images can be used as a means to correct the robot’s trajectory in an off-line manner. In this work, a solution is presented to the problem of selecting the optimal set of viewpoints belonging to the planned path from which to capture and transmit images: 1) it guarantees accurate trajectory correction and 2) complies with the maximum number of images that can be transmitted to ground control given the available data budget. To this end, it is proposed: 1) a delocalized/decentralized sensor fusion approach based on pose graph optimization and structure from motion and 2) a strategy to select a minimal set of viewpoints along the trajectory that, given a tentative geometry of the environment and the global path that the rover must follow, minimizes the uncertainty of all the robot poses. Optimal camera viewpoint positions are selected as a function of the planned trajectory, the approximate scene geometry, and the maximum transmittable number of images. The proposed method has been tested on a dataset of stereo-images collected in a representative Martian environment, the ALTEC Mars Terrain Simulator (MTS), with the ExoMars testing rover (ExoTeR—European Space Agency, Paris, France, property). Rover stereo-images ground truth was given with millimetric accuracy by a motion capture (MC) system.

Abstract Industrial companies today must operate in an increasingly competitive world and need to rethink their organization accordingly. First, industrial strategies concerning technical management need to change and develop. If we consider the specific management of the product design process, managers use indicators during the lifecycle of the product concerning quality, cost and lead-times. For example, some new indicators concerning performance metrics related to cooperation issues among the design team are set up. Secondly, managers increasingly need to integrate the user in the early phases of the design process. The main benefit of this approach is that it allows designers to innovate more rapidly and robustly. The aim of this paper is to introduce a new approach making it possible to calculate a performance indicator concerning use design. The new indicator will help management drive the design process through the integration of use in the product, helping to enhance the usability of the future product, and consequently improve innovation.

This work demonstrates push-push VCOs in K-band (with second harmonic output at 24 GHz) and in Ka-band (with third harmonic output at 36 GHz), and PLL synthesizers on their basis. Oscillators are stabilized by a rectangular resonant metallic cavity. Output signal power within the frequency tuning range changes in the limits of −11,5 - −7,6 dBm and −11,8 - −10,9 dBm for 24 GHz and 36 GHz oscillators respectively. Single sideband (SSB) phase noise spectral densities of –91 dBc/Hz for 24 GHz oscillator and –87,4 dBc/Hz for 36 GHz oscillator at 10 kHz offset from the carrier frequency are at the level of dielectric resonator oscillators (DRO) scaled to the same frequency. The oscillators feature a compact size, low cost quazi-planar design and are built using commercially available off-the-shelf parts.