American College of Healthcare

ABSTRACTBreast cancer (BC) is the second most common cancer in women in the United States. Of those diagnosed, 40–80% will undergo chemotherapy. Adverse effects of chemotherapy are chemotherapy-induced diarrhea (CID) and gut microbiota dysregulation. CID can lead to dehydration, metabolic acidosis, malnutrition, and gut dysbiosis. Antidiarrheal medications are the standard treatment of care; however, this has been shown to further contribute to gut dysbiosis, is not always effective in controlling diarrhea, and can lead to rebound constipation with the potential of pathogenic bacterial overgrowth. In this case report, we describe the experience of a patient-centered, personalized intervention with pre- and probiotics to preserve the microbiota and prevent CID. A 57-year-old postmenopausal female with BC undergoing adriamycin-cyclophosphamide (AC) and taxol-cyclophosphamide (TC) chemotherapies for invasive ductal carcinoma under the care of a cancer team wanted to refrain from using loperamide and instead use nutritional interventions and supplementation for preventing CID and maintaining gut health. This case report is a narrative report of the observed outcomes of one patient with BC after taking specific prebiotics and probiotics. The outcomes included the prevention of CID and other gastrointestinal adverse effects, and maintaining microbiota alpha-diversity, butyrate producing genera, and Bifidobacterium populations while inhibiting the overgrowth of Proteobacteria pathogenic bacteria.

Abiotic stress and plant immunitya challenge in climate change Plants are constantly under various environmental pressure in nature, which affects their growth, reproduction, yield, and survival. Global warming and climate change have aggravated background stress levels, making plant response to stress combinations a pressing concern (Mora et al., 2015; Mankin et al., 2019) . In the coming decades, the geographical areas suitable for growing certain plants are likely to undergo significant changes as a result of varying greenhouse gas and aerosol emission scenarios (Figure 1 provides a specific example in the US). Plants need to sense, sort, and communicate multiple stress signals and then activate downstream responses while simultaneously allocating resources. Thus, the response to multiple stress exposure needs to be studied to tackle the grand challenge of climate change. In this Research Topic issue, several important aspects of abiotic stress and plant immunity have been covered, which could provide some hints to cope with the extreme challenges of feeding the growing world population. Rice, wheat, maize, and potato are the most widely consumed staple crops in the world, providing over 60% of the global food calories and playing a critical role in feeding the growing population. Given their importance for global food security, it is essential to understand how these crops will be impacted by climate change and to develop effective strategies for managing the associated risks. Singh et al. provided a comprehensive summary of the important wheat diseases in the US, covering their host range, symptoms, favorable conditions, disease management, and integrated disease management strategies, while considering the potential impacts of climate change in the coming decades. This information is critical for developing effective disease management practices that account for changing environmental conditions and ensure the sustainability of wheat production in the US and around the world. High temperatures can exacerbate the effects of biotic stresses on plants. Recent studies have shown that cytosolic calcium signaling, including the calmodulin binding protein CBP60g, plays a critical role in ensuring the plant's resilience to high temperatures (Kim et al., 2022) and in mediating the perception of both biotic and abiotic stress (Marcec et al., 2019; Xu et al., 2022) . Carpentier et al. reviewed the current literature on the combined effects of biotic stress and temperature on calcium signaling. The authors highlighted several molecular components in calcium signaling that play an important role in plant responses Frontiers in Plant Science frontiersin.org 01

This biographical essay will provide historical insights about Dr Carl Bodon who performed one of the first successful intracardiac injections of adrenaline to a patient and made important contributions to the understanding of cardiac diseases and women's health. Dr Bodon's biography reveals the story of a medical doctor who lived during tumultuous times between two world wars and ultimately died in the Holocaust. His story sheds light on forgotten contributors to the medical field and its practices.