Applied Design Labs (United States)

The European Broadcasting Union (EBU) Dynamic Media Facility (DMF) provides a layered model for software-defined production infrastructures running on commonly available IT infrastructure. The DMF seeks to enable customizable and dynamic workflows with cost-effective scalability and enhanced operational efficiency, security, and reliability to meet the challenges of the evolving media business landscape. A key element of the DMF is the Media eXchange Layer (MXL), an open source SDK for high-performance live media interchange between containerized software media functions. MXL provides an interoperable vendor-neutral platform with clear observability and uses the lowest latency asynchronous data transfer methods to avoid delays in the live signal chain. Shared memory is used for same-host functions, and remote direct memory access (RDMA) networking will be used for cross-host communication. The Linux Foundation hosts the MXL Project in collaboration with the EBU and the North American Broadcasting Association (NABA). The MXL SDK code is available on a public GitHub repository.

Abstract Psychedelic therapy has the potential to become a revolutionary and transdiagnostic mental health treatment, yielding enduring benefits that are often attributed to the experiences that coincide with peak psychedelic effects. However, there may be an underrecognized temporal structure to this process that helps explain why psychedelic and related altered states of consciousness can have a initially distressing but ultimately a distress-resolving effect. Here we present a qualitative analysis of the self-reported ‘comeup’ or onset phase, and ‘comedown’ or falling phase, of the psychedelic experience. Focusing on psilocybin or psilocybin-containing mushrooms, we show that the comeup is more often characterized by negatively valenced feeling states, while the comedown phase is more often characterized by positively valenced feeling states of the sort often observed following recovery from illness or adversity. In this way, the temporal trajectory of the psychedelic experience could be seen to mimic the narrative arc of the monomythical ‘Hero’s Journey’.

Networks of coupled parametric oscillators exhibiting binary phase state can be used for computation. The phase relation between oscillators can be switched with frequency detuning.

The opioid public health crisis continues to burden individuals, communities, and economies. Public health opinion has emphasized the need for increased access to harm reduction services, but there is a dearth of information on the views and experiences of people who use opioids. Our study aimed to investigate the prevalence of naloxone use, attitudes, and experiences with naloxone among an online community of people who use drugs. We performed a cross-sectional survey looking at experiences with and attitudes towards take-home naloxone. Data is presented descriptively, with analysis of the differences between people who do and do not use opioids using the χ2 and Fisher's exact tests. There were 1,143 respondents, of whom 70%were from the United States. Only 38% of participants who use opioids had received naloxone training, but 56% of these individuals said that they felt comfortable using a naloxone kit. Nearly all respondents (95%) said they would be willing to use naloxone on someone who had overdosed and approximately 90% would want naloxone used on them in case of an overdose. Regarding harm reduction, 24% of respondents said they had access to safe use programs, and 33% said they had access to clean needle exchange programs. A majority of the participants who use opioids were in favor of having naloxone with them when using drugs and believed naloxone should be freely available. This study demonstrates the receptiveness of take-home naloxone and highlights the need for better implementation of naloxone within communities that use opioids.

When a high-voltage charged tether is put into streaming space plasma, the tether’s electric field disturbs the flow of plasma ions and thereby taps momentum from the plasma flow [1-4]. The effect is called electrostatic Coulomb drag. One application is the electric solar wind sail which uses the solar wind to generate interplanetary propulsion [1, 2]. Another application is the Plasma Brake [3, 4] which uses the ionospheric ram flow to generate Coulomb drag that slowly de-orbits the satellite. Both positive and negative tether polarities work. The plasma physics is different, but the net effect is a transfer of momentum in both cases. The reasons are somewhat complicated, but there is good motivation to select positive polarity in the solar wind case and negative polarity in the ionospheric Plasma Brake case. Measurement of Coulomb drag in Low Earth Orbit and testing deployment of tether is to be carried out by ESTCube-2 cubesat [5] which is scheduled for launch in spring 2023, and forthcoming Foresail cubesat scheduled for launch later in 2023-2024.Project DragLiner is ongoing and funded by ESA to define requirements and a preliminary design of a passive Coulomb Drag based deorbit system capable of bringing down LEO spacecrafts in an order of magnitude shorter time than the current regulations of re-enter time for the spacecraft (25 years). Other main requirements for the deorbiting system are low mass and independence from the spacecraft resources. The project will also create a TRL 4 prototype of a Plasma Brake module that can be used to deorbit a few hundred kilogram satellite or launcher upper stage from Low Earth Orbit. The module deploys ~5 km long tether that is made of four 25-50 micrometre diameter conductive wires. In addition to aluminium wires used previously in Cubesat projects we will also evaluate more advanced carbon fibre composite wires. The redundant multi-wire tether structure is used so that the tether does not break even when micrometeoroids cut some of its wires. The tether is deployed from a storage reel. The tether is kept at -1 kV voltage by an onboard high-voltage source. A ~100 m long metal-coated tape tether is used as an electron-gathering surface that closes the current loop. Alternatively, conducting parts of the debris satellite could be used for electron gathering. The power consumption is a few watts. Project Dragliner uses basic Space Plasma Physics to solve a practical and important problem of keeping satellite orbits clean for future generations and preventing a catastrophic Kessler syndrome scenario.[1] Janhunen, P., Electric sail for spacecraft propulsion, J. Prop. Power, 20, 763-764, 2004.[2] Janhunen, P. and A. Sandroos, Simulation study of solar wind push on a charged wire: basis of solar wind electric sail propulsion, Ann. Geophys., 25, 755-767, 2007.[3] Janhunen, P., Electrostatic plasma brake for deorbiting a satellite, J. Prop. Power, 26, 370-372, 2010.[4] Janhunen, P., Simulation study of the plasma-brake effect, Ann. Geophys., 32, 1207-1216, 2014.[5] Iakubivskyi, I., et al., Coulomb drag propulsion experiment of ESTCube-2 and FORESAIL-1, Acta Astronautica, 177, 771-783, 2020.

Dermatologic patients are expressing increasing interest in minimally invasive procedures to address a wide range of common concerns from skin laxity to acne and scarring. Fractional radiofrequency (RF) microneedling offers an effective method for addressing a variety of dermatologic conditions with reduced downtime compared with historically more invasive procedural approaches. This article aims to describe the technology utilized in fractional RF microneedling (Morpheus8, InMode Aesthetics) and its studied applications in dermatology for treatment of the face.

Psychedelics show promise in treating unipolar depression, though patients with bipolar disorder have been excluded from recent psychedelic trials. There is limited information on the use of classic psychedelics (e. g., LSD or psilocybin) in individuals using mood stabilizers to treat bipolar disorder. This is important to know, as individuals with bipolar depression may attempt to treat themselves with psychedelics while on a mood stabilizer, particularly given enthusiastic media reports of the efficacy of psilocybin for depression. This study analyzed reports of classic psychedelics administered with mood stabilizers from 3 websites (Erowid.org, Shroomery.org, and Reddit.com). Strikingly, 47% of 62 lithium plus psychedelic reports involved seizures, and an additional 18% resulted in bad trips while none of 34 lamotrigine reports did. Further, 39% of lithium reports involved medical attention. Most of the lamotrigine reports (65%) but few (8%) of the lithium reports were judged to not affect the psychedelic experience. Although further research is needed, we provisionally conclude that psychedelic use may pose a significant seizure risk for patients on lithium.