Arignar Anna Memorial Cancer Hospital & Research Institute

Background: Acute pancreatitis (AP) is an inflammatory disorder with potential progression to pancreatic necrosis, which significantly increases morbidity and mortality. Hematological indices such as the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) have emerged as potential early markers of systemic inflammation. This study aimed to evaluate the utility of NLR and PLR in predicting pancreatic necrosis in patients with AP. Methods: This prospective observational study included 130 patients with acute pancreatitis admitted to Government Royapettah Hospital, Chennai, India, from April 2019 to September 2020. Blood samples were collected at admission (Day 0), 24 hours (Day 1), and 48 hours (Day 2) to calculate NLR and PLR. Pancreatic necrosis was assessed using contrast-enhanced CT (CECT). Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of NLR and PLR were analyzed, and combined performance was evaluated. Results: The cohort comprised 121 males (93.1%) and 9 females (6.9%), with a mean age of 40.65 ? 7.5 years. Alcohol was the most common etiological factor (96%). Mild pancreatitis accounted for 77.7% of cases, while severe pancreatitis represented 22.3%. NLR demonstrated higher sensitivity and NPV compared to PLR at all time points. At 48 hours, NLR sensitivity and specificity were 62.2% and 91.2%, respectively, while PLR sensitivity and specificity were 59% and 80.2%. Combined assessment of NLR and PLR improved early detection of pancreatic necrosis, achieving the highest diagnostic accuracy. Conclusion: NLR and PLR are elevated in patients with necrotizing pancreatitis, with NLR showing superior predictive performance. Their combined use further enhances early identification of high-risk patients, offering a simple, inexpensive, and readily available tool for early prognostication in acute pancreatitis.

This article aims to provide a comprehensive investigation into the concept of ideals within various semigroup classes, focusing on their properties, characterization, and role in algebraic structures. The research will cover classical semigroup theories, including regular semigroups, monoids, and groups, as well as less conventional semigroup classes, such as inverse semigroups, transformative semigroups, and idempotent semigroups. By delving into the intricacies of each semigroup type's ideal structures, this work seeks to expand the current understanding of these algebraic structures, offering new insights and potential applications in various fields, such as computer science, mathematics, and theoretical physics.

Abstract Designing and synthesizing of transition metal oxide complex nanostructures were involving a high-capacity electrodes for energy storage applications. In this research work, we have systematically synthesised the V2O5/Al2O3 composite electrode which is evaluated the charge storage activities in an aqueous system to confirmed the supercapacitor properties. Further, the obtained composite electrode was estimated by various physico-chemical techniques. The XRD pattern, FE-SEM, TEM images and BET analysis were confirms orthorhombic crystalline structure of V2O5/Al2O3 as mixed crystalline in phase and good formation of the composite electrode with remarkable porous properties. The charge storage activities of this composite electrode were evaluated via three-electrode system in 1 M KOH electrolyte solution. As output result, the V2O5/Al2O3 composite electrode achieved the 746.6 F g− 1 at the current density value of 1 A g− 1. Interestingly, the electrode was attained the 87.4% stability retention in 3000 cycles. These acceptable electrochemical performances are ascribed to the synergistic effect metal oxides, which is coexistence of various electronic states of this V2O5/Al2O3 composite.

Quantum computational simulations based on density functional theory are employed to investigate the molecular structure of Retinol. Both geometrical parameters and electronic transitions for gas and green solvents are calculated. Characteristic frequencies were identified and band assignments were achieved through normal coordinate analysis. The calculated spectra and a comparative study of the vibrational spectra, which included a variety of vibration modes, were compared with the experimental spectra. A compound’s strong reactivity may be indicated by the bandgap, which also indicates the possibility of further charge exchange through the molecule. Determination of relative electrophilicity/nucleophilicity indices of retinol was undertaken through the prediction of condensed Fukui functions, complemented by the generation of molecular electrostatic potential surface maps. This exploration was validated through meticulous correlation with reduced density gradient and isodensity surface plots. The docking analysis of retinol with different proteins was performed to confirm anti-inflammatory activity. To gain comprehensive insights into macromolecule pliability concerning protein–ligand interactions, an effective molecular dynamics simulation was conducted.

An aqueous extract of Phyllanthus Emblica fruit extract was used as a precursor in the effective synthesis of Magnesium Oxide Nanoparticles (MgONP) and the same was calcined at different temperatures. The thermal study demonstrated that MgO nanoparticles evolved from Mg(OH)2 by the identification of characteristic weight loss curves and endothermic peaks in TGA and DTA, respectively. UV-visible analysis showed that the peak shifts to a longer wavelength at 350 nm when the calcination temperature rises from 200 to 600 °C, indicating a decrease in the size of MgONP particles. On the other hand, Tauc plot analysis showed that the band gaps between the precursor and calcined MgO samples varied from 5.84 to 3.70 eV. FTIR and XRD analysis confirmed the synthesis of MgONPs from Mg(OH)2 exhibiting spherical shapes of around 20 nm in size.Twenty minutes of exposure to sunshine caused the dye's colour to entirely vanish, demonstrating the remarkable photocatalytic effectiveness of MgONP calcined at 600 °C. The effective breakdown of Acid Violet was confirmed by the rate constant of the photocatalytic behaviour increasing proportionately with the catalyst dose. Furthermore, it was suggested by the Langmuir and Freundlich isotherm models that Acid Violet efficiently adheres to the photocatalyst surface when R2 values are nearer to 1. There are several potential applications for MgO nano adsorbents in dye removal processes, as evidenced by desorption studies that showed their reusability.

Background: Oral cancer is often detected in the advanced stage, with a low survival rate of 5 years and with increase in mortality which, affects patient quality of life. The early diagnosis would reduce the mortality rate and morbidity rate, by bringing a change in the quality of life. Methods: The study utilized convenient sampling method to select the participants. Participants who were diagnosed with oral cancer currently at 3rd and 4th stage. Data collection was done using pre-validated self-administered questionnaire, which was provided to the participants through Google forms. Results: The study demonstrated 43.1% people diagnosed with stage-3 oral cancer had an average delay of 34.6 months and 26% of stage-4 cancer patient had an average delay of 59.9 months to their first visit to treatment center. In this study 34% of the study participants were unaware and had lack of knowledge about oral cancer related symptoms. Self-medications/herbal medications, fear for the treatment, socio-economic factors, COVID-19/ lockdown restriction were also other reasons reported by patients. Conclusions: The prompt treatment is necessary in both advanced cases and early cases of oral cancer. Radiotherapy, chemotherapy, and surgery are all part of the treatment when given timely. Thus, early diagnosis plays a vital role in saving many live.

The COVID-19 pandemic, which began in 2019, had a significant impact on countries around the world, including India. During this situation, many companies faced catastrophic losses. Amid this challenging period, banks played a key role in helping both companies and the general public in meeting their financial and daily needs. E-banking is more convenient and time-saving for paying utility bills for the television, electricity, recharge, and rent bills, booking a cylinder, insurance, online shopping, and other areas. It is easily accessed through a computer, smartphone, laptop, tablet, and so on. Customers are more satisfied with e-banking services during the lockdown period, particularly in relation to essential transactions such as the purchase of food and medicines. E-banking also provided a sense of security and comfort during the pandemic. With built-in security systems, password protection, and the requirement of a stable internet connection, it ensured safe transactions. Customers could stay at home and access their accounts from anywhere and at any time to avail themselves of e-banking services. A primary data study was conducted using a structured questionnaire. The data was collected from 120 respondents. The main objective of the research paper is to identify the satisfaction level of e-banking customers during the COVID-19 period. The findings suggest that the majority of respondents preferred e-banking for its ability to save time and energy. Most customers reported feeling safe and found online transactions to be easily accessible. Hence, the present study aims to evaluate the effectiveness of e- banking services during the COVID-19 period, highlighting how these services met customer expectations and supported daily life during an unprecedented global crisis.