Arturo Prat University

Resumen: Este manuscrito examina la complejidad creciente de la ciberadiccin, un fenmeno cada vez ms normalizado socialmente pero aun insuficientemente investigado y regulado.La ciberadiccin comparte rasgos con otras formas de dependencia, al surgir de experiencias de placer inmediato que pueden transformarse en necesidad.Desde una perspectiva multidisciplinaria, el texto analiza factores histricos, familiares, neurobiolgicos y sociotcnicos que contribuyen a su desarrollo, destacando el papel del placer digital y de las arquitecturas tecnolgicas diseadas para captar y retener la atencin del usuario.Asimismo, se abordan los dilemas ticos asociados a su conceptualizacin, interrogando si la ciberadiccin constituye un trastorno autnomo o una manifestacin de transformaciones ms amplias en la relacin humana con la tecnologa.El manuscrito profundiza en tensiones vinculadas a autonoma, vulnerabilidad, responsabilidad corporativa y privacidad, proponiendo un enfoque que reconoce la complejidad moral del ecosistema digital contemporneo.En conjunto, el trabajo articula aportes de la neurociencia, la psicologa, la biotica y los estudios sociotcnicos para ofrecer una comprensin integrada del fenmeno.Se plantea la necesidad de equilibrar los beneficios del uso intensivo de tecnologas con los riesgos asociados, promoviendo prcticas que favorezcan un uso saludable, crtico y ticamente responsable.En sntesis, se sita la ciberadiccin como un desafo emergente de la era digital.

Background Despite growing scientific evidence and health guidelines, the global health paradox persists, with rising lifestyle-related diseases and escalating healthcare costs exposing the inadequacy of current efforts. Objective Three multidisciplinary congresses were held to generate evidence-based conclusions aimed at addressing the global health paradox. Methods A total of 58 experts from 62 entities participated in the international research and knowledge-exchange panels. Experts reviewed the latest findings to develop practical strategies and identify key research and policy priorities, focusing on the Healthy Eating & Active Living (HEAL) approach. Results, conclusion, and relevance The expert consortium endorsed a 33 evidence-based consensual-statement policy roadmap for addressing global health challenges, emphasizing that the HEAL approach can significantly contribute to the “Prevention First” appeal and broad ethical, social, ecological, and economic advantages, and ultimately supporting policy change.

In this work, the electrochemical behavior of potassium jarosite-type solid solutions synthesized via a controlled hydrothermal method was evaluated. Structural characterization by X-ray diffraction (XRD) confirmed the formation of potassium jarosite. FTIR spectra complemented these findings, revealing bands characteristic of Fe-O metal coordination (625 and 505 cm-1). Voltammetric tests evidenced redox processes attributable to the Fe3+/Fe2+ couple, suggesting that iron within the jarosite framework contributes electrochemically to the observed conductivity. The assembled galvanic cells demonstrated the capability for electrical energy microgeneration, and the presence of jarosite was found to enhance ionic transport within the system. Overall, these results suggest an intergranular ionic-conduction mechanism, possibly facilitated by the mineral matrix, which would act as a structural medium enabling the mobility of charged species.

The rapid digital transformation of education systems has profoundly changed teachers' working conditions, intensified administrative demands, and highlighted territorial and organizational inequalities. In this context, understanding how these dynamics influence teacher engagement is essential for promoting healthy educational organizations. This study examined the factor structure of the UWES-17 and analyzed the relationship between engagement levels and sociodemographic variables in a sample of 314 elementary school teachers from four regions of Chile. Descriptive analyses, exploratory factor analysis with polychoric correlations and unweighted least squares, and confirmatory factor analysis using robust ULS and the Hull method were performed. The results showed a robust two-factor structure-Inspired Vitality and Challenging Commitment-with excellent fit indices. Freeman-Halton exact tests showed that Inspired Vitality was significantly associated with age, gender, region, location, administrative dependency, and professional experience, while Challenging Commitment was associated with gender, region, context, and professional experience. These findings indicate that teacher engagement is influenced by both structural inequalities and individual trajectories. The results underscore the need to strengthen organizational resources, regulate digital intensification, and reduce territorial gaps to promote teacher well-being.

Physical exercise is a potent non-pharmacological strategy for the prevention and management of Metabolic dysfunction-associated steatotic liver disease (MASLD), a multifactorial disorder characterized by hepatic lipid accumulation, insulin resistance, oxidative stress, and chronic inflammation. Emerging evidence demonstrates that the benefits of exercise extend beyond caloric expenditure and are largely mediated by coordinated molecular and cellular adaptations within the liver and peripheral tissues. This review synthesizes current knowledge on the mechanisms through which exercise modulates MASLD pathophysiology, emphasizing intracellular signaling pathways, mitochondrial remodeling, antioxidant defenses, and myokine-driven muscle-liver crosstalk. Exercise induces acute and chronic activation of pathways such as AMPK, PGC-1α, Nrf2, and Akt, resulting in enhanced mitochondrial biogenesis, improved fatty acid oxidation, restored insulin signaling, and reduced inflammatory and oxidative stress. Repeated skeletal muscle contraction stimulates the release of myokines-including irisin, IL-6, and FGF21-that act through endocrine and paracrine routes to regulate hepatic lipid metabolism, promote systemic metabolic flexibility, and attenuate disease progression. Epigenetic modifications and exercise-responsive microRNAs further contribute to long-term hepatic metabolic reprogramming. Collectively, these molecular adaptations position exercise as a systemic, disease-modifying stimulus capable of restoring hepatic homeostasis, slowing the transition from steatosis to NASH and fibrosis, and improving long-term metabolic health. Understanding these mechanisms provides a foundation for developing targeted, personalized exercise-based interventions in the clinical management of MASLD.

Handgrip strength (HGS) has been considered as an indicator of muscle strength and overall physical fitness, with increasing relevance in sports science for talent identification and performance monitoring. However, no bibliometric study has been conducted to map the HGS research landscape in athletic contexts. A bibliometric analysis was conducted in the Web of Science Core Collection database, retrieving 229 publications. Typical bibliometric laws (i.e., Price's, Bradford's, Lotka's, and Zipf's) were employed to analyze publication trends, core journals, influential authors, country contributions, and keyword co-occurrences. Annual publications increased exponentially, especially after 2019, reaching 37 documents in 2024. The Journal of Strength and Conditioning Research and Journal of Sports Medicine and Physical Fitness were the most prominent journals. The United States and Spain led in productivity and impact. Key research themes included strength, performance, body composition, and physical fitness, with HGS demonstrating significant associations with sport tasks such as throwing, racquet sports, and weightlifting. HGS constitutes an accessible and valuable tool for assessing and predicting athletic performance, especially in sports requiring upper body strength and coordination. Future research should aim to expand database inclusion and address identified gaps, such as the relationship between HGS training and sport-specific outcomes.

Calophyllum spp. infusions are used to treat varicose veins, hemorrhoids, and hypertension. However, the chemical composition and mechanisms of action are poorly understood. Accordingly, the aim of this study was to investigate the phytochemical composition and vascular effects of hydroalcoholic extracts of Calophyllum longifolium. Phytochemical profiling was performed using ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UHPLC-ESI-Q-TOF-MS). Extract effects on rat aortic rings and aortic vascular smooth muscle cells (VSMCs) were evaluated using wire myography and photometric measurement of intracellular Ca2+, respectively. UHPLC-ESI-Q-TOF-MS revealed the presence of coumarins, xanthones, flavonoids, triterpenes, and phenolic acids. Coumarin-resveratrol hybrids, such as gut-70 derivatives, were also abundant. In aortic rings from normotensive rats, C. longifolium induced a biphasic vascular response whereby low concentrations (1 μg/mL) produced significant vascular relaxation, whereas high concentrations (100 μg/mL) produced contraction. Blockade of ATP-sensitive (KATP) or voltage-gated (KV) potassium channels attenuated these effects. Furthermore, effects were not observed in preparations preincubated with L-NG-Nitro-L-arginine methyl ester (L-NAME) or in endothelium-denuded rings. In aortic VSMCs, extracts (1 µg/mL) rapidly reduced sarcoplasmic reticulum (SR) Ca2+ content. This study provides the first UHPLC-ESI-Q-TOF-MS chemical profile of C. longifolium, revealing diverse bioactive metabolites. It is also the first to demonstrate that C. longifolium exerts an endothelium-dependent, nitric oxide- and Ca2+-mediated biphasic effect on vascular function. Taken together, these findings highlight C. longifolium as a potential novel source of vasculotropic phytopharmaceuticals.

Este estudio tuvo por objetivo explorar el alcance formativo de la lectura de relatos en la formación inicial. Asumiendo que la formación debe orientarse epistémicamente hacia la práctica, empleamos una metodología fenomenológica y hermenéutica para interrogar el sentido formativo que tiene narrar experiencias significativas de las pasantías de práctica (practicum). Los resultados del análisis temático de 67 informes reflexivos muestran que relatar experiencias posibilita a) acrecentar el conocimiento que poseen sobre experiencias escolares, b) ahondar analíticamente en los significados educativos que tienen las vivencias y c) desarrollar una sensibilidad pedagógica en relación con aquello que se va reflexionando e interpela subjetivamente a educadores en formación. Las conclusiones destacan la importancia de compartir relatos para ampliar el sentido de lo que significa educar y valoran el potencial formativo de las narrativas para los programas de pedagogía que buscan dar centralidad a la reflexión docente.