Arvia Technology (United Kingdom)

<div> <p><em>We present the SESAR funded project ALARM. The overall objective of ALARM is to develop a prototype global multi-hazard monitoring and Early Warning System for different hazards affecting aviation. Continuous global Earth observations from satellite, ground-based systems, and atmospheric forecasts will be used to feed models capable of observing and predicting (nowcasting/forecasting) the displacement of particles in suspension and gas derived from natural hazards (volcanic ash and SO2, dust clouds from sandstorms, and smoke from a forest fire); severe weather situations such as deep convection and extreme weather; exposure to increased levels of solar radiation during flight; and environmental hotspots potentially contributing to global warming in a large extent. Specifically, the aim is to enhance situational awareness of all stakeholders in case of multiple hazard crisis by facilitating the transfer of required relevant information to end-users, presenting such information in a user-friendly manner to ATM stakeholders. In summary, anticipating severe hazards and fostering better decision-making.</em></p> <ul><li><em>ALARM will enhance an existing alert system –– with additional observations coming from geostationary satellites, improving the capabilities of observing natural hazards such as volcanic ash, SO2 plumes, sandstorms, and forest fire.</em></li> <li><em>ALARM will tailor alert products (based on observations from satellites) of volcanic ash, SO2 plumes, sandstorms, and forest fire to aviation stakeholders, including its severity, geographical location, and altitude.</em></li> <li><em>ALARM will develop nowcasting [up to 2 hours] and short-term forecasting [up to 6 hours] of SO2 plumes at a regional scale.</em></li> <li><em>ALARM will develop nowcasting [up to 2 hours] and short-term forecasting [up to 6 hours] of severe thunderstorms at a local scale (airport).</em></li> <li><em>ALARM will develop short-term forecasting [up to 6 hours] and medium-term forecasting [up to 48 hours] of climatic hotspots at a European scale.</em></li> <li><em>ALARM will draft the requirements of all these alert products to be included in the SWIM Yellow profile.</em></li> </ul><p> </p> </div>

Introduction:Arginineemia, also known as arginase deficiency, is a rare autosomal recessive metabolic disease. The diagnosis sometimes may be delayed due to atypical clinical manifestations. Confirmation of arginineemia depends on genetic testing.Patient concerns:We reported a Chinese male child presenting with hyperargininemia and progressive spastic diplegia, who has a novel compound heterozygous mutation in the arginase-1 (ARG1) gene (c.263-266delAGAA, p.K88Rfs∗45;c.674T>C,p.L216P), respectively, coming from his mother and father.Diagnosis:The patient was diagnosed with argininemia with a novel compound homozygous mutation of the ARG1 gene at the age of 12 years.Interventions:The patient had a low-protein diet (0.8 g/kg/day). Baclofen, eperisone hydrochloride, botulinum toxin, and rehabilitation training were used to improve his spastic diplegia symptoms for 3 months.Outcomes:The patient's blood arginine was still high after 3 months’ low-protein diet. His spastic diplegia symptoms had not aggravated after 3 months’ treatment.Conclusions:Argininemia should be considered in a patient with slowly progressive neurologic manifestations, especially spastic diplegia. This case also suggests that tandem mass spectrometry should be used as an effective tool in the validity of neonatal screening for early diagnosis.

The removal of the mercaptan, 1-methyl-1-propanethiol, from aqueous solutions using a non-porous, electrically conducting carbon-based adsorbent (Nyex 1000) was investigated. The adsorption process was found to be rapid (equilibrium capacity achieved within 5 minutes) with low adsorptive capacity (of the order of 0.4 mg g(-1)) when compared with activated carbon. Electrochemical regeneration of the Nyex 1000 in a simple divided electrochemical cell within a sequential batch treatment unit restored 100% of the adsorbent's adsorptive capacity using treatment times as low as 20 minutes by passing a current of 0.5 A. The sorptive characteristics of a Nyex-water slurry were also modelled and investigated both in a bubble column and in a continuous adsorption-regeneration treatment system. It was demonstrated that the continuous removal-destruction system could achieve a step reduction in challenge gas concentration of approximately 75% for a period of 35 minutes with a current of 5 Amps. This was attributed to mass transfer enhanced by a combination of adsorption and chemical reaction with free chlorine species generated in the electrochemical process.