BOC (Austria)

A deep-intronic single nucleotide variant in RUNX2 causes the characteristic clinical features of cleidocranial dysplasia (CCD) in a family via pseudo-exon inclusion into the mRNA. The pseudo-exon contains a premature stop codon and triggers mRNA decay, which results in RUNX2 haploinsufficiency, the known disease mechanism.

Business Agility is a crucial aspect of modern organizations, reflecting their ability to adapt and thrive in a rapidly changing business landscape. At its core, Business Agility involves being responsive to change, allowing companies to swiftly adjust their strategies and operations in response to market shifts, emerging technologies, and evolving customer demands. Developer Platforms play a pivotal role in fostering Business Agility. These platforms provide a foundation for building and deploying applications, enabling developers to collaborate seamlessly and iterate rapidly. Utilizing metamodeling concepts and agile methodologies throughout the stages of creation, design, formalization, development, deployment, and validation enables the introduction of a generic metamodel for Developer Platforms. This approach enhances the adaptability to changes and technological advancements. The essential elements of this metamodel are detailed in this paper, underscoring the significance of conceptual groundwork as a mission-critical step prior to initiating the orchestration or implementation of the Developer Platform’s actual services and tools.

This chapter describes a modeling method that has been conceived to support learning in public administrations. The modeling method foresees the description of both procedures in the public administrations, and the working context of the civil servants. The approach relies on several model types that are used to organize and to relate the knowledge needed by civil servants in order to perform their daily activities. Each model instance describes a view on the concerns expressed by the model type it conforms to. These descriptions intend to provide an easy way for civil servants to retrieve knowledge when they need to learn specific aspects of a procedure, and to make collaboration easier in order to enable the emergence of knowledge related to the procedures themselves. Indeed, the method comes with an infrastructure that allows to automatically set up a wiki-based collaborative platform enabling collaboration and knowledge sharing among the stakeholders involved in the activities of a Public Administration. This chapter mainly reports on the modeling method that was conceived and developed within the FP7 EU research project Learn PAd. Learning aspects, while clearly relevant for the project, will not be directly discussed here.

The growth in the number of cloud computing users has led to the availability of a variety of cloud based services provided by different vendors. This has made the task of selecting suitable set of services quite difficult. There has been a lot of research towards the development of suitable decision support system (DSS) to assist users in making an optimal selection of cloud services. However, existing decision support systems cannot address two crucial issues: firstly, the involvement of both business and technical perspectives in decision making simultaneously and, secondly, the multiple-clouds services based selection using single DSS. In this paper, we tackle these issues in the light of solving the problem of cloud service discovery. In particular, we present the following novel contributions: Firstly, we present critical analysis of the state-of-the-art in decision support systems. Based on our analysis, we identify critical shortcomings in the existent tools and develop the set of requirements which should be met by a potential DSS. Secondly, we present a new holistic framework for the development of DSS which allows a pragmatic description of user requirements. Additionally, the data gathering and analysis is studied as an integral part of the proposedDSS and therefore, we present concrete algorithms to assess the data for an optimal service discovery. Thirdly, we assess our framework for applicability to cloud service selection using an industrial case study. We also demonstrate the implementation and performance of our proposed framework using a prototype which serves as a proof of concept. Overall, this paper provides novel and holistic framework for development of a multiple cloud service discovery based decision support system.

This paper describes experiences of using meta-modelling tools supporting technology enhanced learning in European Commission's project NEXT-TELL. Due to a target group of the project (teachers with limited experience in modelling) it was very important to provide them with easy to use environment. This resulted in trying to identify least best fit of features needed by teachers while removing “distractions” - both in regards to tool functionality and modelling method applied. Such adjustments of the modelling tool were possible thanks to the underlying ADOxx® meta-modelling platform that allowed adjustment to feedback received from end users/subject matter experts in terms of functionality and usability.

Innerhalb des Prozessmanagements werden durch die Prozessanalyse operationelle Risiken identifiziert und bewertet, die das Erreichen der Prozessziele sowie im Weiteren das Erreichen der Unternehmensziele erschweren oder sogar verhindern. Diesen operationellen Risiken zu begegnen, ist die Aufgabe des Internen Kontrollsystems (IKS), das Sorge dafur zu tragen hat, die Prozessziele zu erreichen, Vermogenswerte zu sichern und gesetzliche Vorgaben einzuhalten. Das Verhindern und Vermeiden von operationellen Risiken durch das IKS sollte auf effektive und effiziente Weise erfolgen. Um dies zu gewahrleisten, ist es essentiell, die Managementsysteme Risikomanagement und Prozessmanagement integriert zu betrachten. Dieses Kapitel zeigt die wesentlichen Anknupfungspunkte der Integration dieser Managementsysteme mittels unseres Vorgehensmodells fur das Interne Kontrollsystem – des „IKS-Life Cycle“ – auf. Anhand dieses Vorgehensmodells, welches sich in die Phasen „IKS-Strategie“, „Risikoanalyse“, „Kontrolldefinition und Risikooptimierung“, „Implementierung der Kontrollen“, „Ausfuhrung der Kontrollen“ und „Evaluierung der Risiken und Kontrollen“ gliedert, wird die Integration im Detail erlautert. Abschliesend stellt dieses Kapitel das IKS als Erfolgsfaktor fur das Prozessmanagement dar und zeigt auf, wie es mithilfe von Methoden des unternehmensweiten Risikomanagements laufend verbessert werden kann.

Abstract In the domain of network management and operation support systems (OSS), maintainance of thousands of physical network devices is a complex, error-prone and time-consuming task. Consistent device configuration and error identification among plethora of network device types is impossible without tool support. Domain-specific modelling (DSM) methods promise to deal with system complexity by raising the level of abstraction to models. In this paper, we report about conceptualization of a DSM method for physical devices management, that is implemented based on the ADOxx metamodelling platform. The method introduces a hybrid modelling approach. A dedicated DSML is used to model the structure of physical devices, whereas the ontology language OWL2 is used to specify configuration-related constraints. The work resulted in a novel semantic modelling tool prototype that leverage ontology reasoning technology to enhance the modelling.KeywordsModelling MethodsDomain-specific ModellingMetamodelling PlatformsModelling ToolsSemantic TechnologyCase Study

Today we are witnessing the necessity to align Business and Information Technology (IT) as well as a change in the role of IT from an enabler to an industrial sector in its own right. Based on the assumption that businesses in different sectors of the economy will require IT for different reasons and in different ways, this article introduces the EU project plugIT that aspires to develop an IT-Socket that will realize the vision of businesses "plugging-in" to IT. Three demonstration scenarios deal with: (1) "Certification" of IT infrastructure to stay compliant with regulations, (2) "Virtual Organisation" by evolving the current service orientation to a higher and more business driven abstraction as well as, (3) "Governance" of IT infrastructure introducing business context into highly distributed and complex systems. The IT-Socket follows a model-driven approach by introducing graphical modelling languages as mediators between the domain experts and IT. The research challenge is to link human interpretable graphical models – partly semi-formal – with machine interpretable semantic formalisms to enable: (1) a tighter involvement of domain experts when expressing formal knowledge specifying business requirements on IT infrastructure and services, (2) different graphical modelling languages for different views on the IT-Socket to provide modelling languages the domain expert is used to work with as well as, (3) a domain specific notation for semantics by integrating formal concepts of semantics with the graphic notation from modelling languages.

As a result of recent changes in the IT, where the role of IT has shifted from an enabler to an industrial sector in its own right, the necessity to provide framework which would allow seamless alignment of the business and IT rose. The goal was to allow the stakeholders from the business as well as IT perspective to model the requirements for the IT service provisioning using the modeling languages they are familiar with and to apply semantic technologies as a mediator that will allow translation between them. IT-Socket, the model based approach for business and IT alignment, developed in the European Research project – plugIT, aims to realize the vision of businesses “plugging-in” to IT by introducing graphical modeling languages as mediators between the domain experts and IT. The research challenges identified include the ability to perform integration and translation between graphical modeling languages by building the reference ontology, enabling automatic generation of machine interpretable domain ontologies from graphical models and allowing automatic translation between domain ontologies. The results of the application of the IT-Socket for business and IT alignment are presented within three use cases: (1) “Certification” of IT infrastructure, (2) “Virtual Organization” by evolving the current service orientation to a higher and more business driven abstraction and (3) “Governance” of IT infrastructure.

At present, state-of-the-art business process management tools usually offer hard-coded methods, that are only partially adaptable. Tools based on metamodeling concepts are bere named next-generation tools, The paper describes the potential of these tools by taking ADONIS as an exam ple. Based on the explanation of the ADONIS concepts three application areas and its corresponding methods are presented: The integrated management of products and busi ness processes, the development of workflow applications and the model-based configura tion of standard software.