BVI (United States)

BioStatFlow is a free web application, useful to facilitate the performance of statistical analyses of "omics", including metabolomics, data using R packages. It is a fast and easy on-line tool for biologists who are not experts in univariate and multivariate statistics, do not have time to learn R language, and only have basic notions in biostatistics. It guides the biologist through the different steps of a statistical workflow, from data normalization and imputation of missing data to univariate and multivariate analyses. It also includes tools to reconstruct and visualize networks based on correlations. All outputs are easily saved in a session or downloaded. New analytical modules can be easily included upon request. BioStatFlow is available online: http://biostatflow.org

The economic cost of breast cancer is a major personal and public health problem in the United States. This study aims to evaluate the insurance, employment, and financial experiences of young female breast cancer survivors and to assess factors associated with financial decline. We recruited 830 women under 40 years of age diagnosed with breast cancer between January 2013 and December 2014. The study population was identified through California, Florida, Georgia, and North Carolina population-based cancer registries. The cross-sectional survey was fielded in 2017 and included questions on demographics, insurance, employment, out-of-pocket costs, and financial well-being. We present descriptive statistics and multivariate analysis to assess factors associated with financial decline. Although 92.5% of the respondents were continuously insured over the past 12 months, 9.5% paid a "higher price than expected" for coverage. Common concerns among the 73.4% of respondents who were employed at diagnosis included increased paid (55.1%) or unpaid (47.3%) time off, suffering job performance (23.2%), and staying at (30.2%) or avoiding changing (23.5%) jobs for health insurance purposes. Overall, 47.0% experienced financial decline due to treatment-related costs. Patients with some college education, multiple comorbidities, late stage diagnoses, and self-funded insurance were most vulnerable. The breast cancer diagnosis created financial hardship for half the respondents and led to myriad challenges in maintaining employment. Employment decisions were heavily influenced by the need to maintain health insurance coverage. This study finds that a breast cancer diagnosis in young women can result in employment disruption and financial decline.

The inside cover picture shows the discovery of a potent BTK inhibitor (orange) by affinity-based selection from a DNA-encoded library (top). Addition of ATP (beige) to the selection, which simulates the intracellular environment, displaced any low affinity compounds (purple) but could not displace the high affinity inhibitor. As predicted by the selection results, the high affinity BTK inhibitor demonstrated potent cellular activity. More information can be found in the full paper by J. W. Cuozzo et al. on page 864 in Issue 9, 2017 (DOI: 10.1002/cbic.201600573).

The motivations to make ultraviolet (UV) studies of supernovae (SNe) are reviewed and discussed in the light of the results obtained so far by means of IUE and HST observations. It appears that UV studies of SNe can, and do lead to fundamental results not only for our understanding of the SN phenomenon, such as the kinematics and the metallicity of the ejecta, but also for exciting new findings in Cosmology, such as the tantalizing evidence for “dark energy” that seems to pervade the Universe and to dominate its energetics. The need for additional and more detailed UV observations is also considered and discussed.

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation F. Mannucci, N. Panagia, M. Della Valle; The bimodality of type Ia Supernovae. AIP Conf. Proc. 9 October 2007; 937 (1): 293–297. https://doi.org/10.1063/1.3682919 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search