Bainbridge Development Corporation (United States)

Delirium is common, morbid, and costly, yet its biology is poorly understood. We aimed to develop a multi-protein signature of delirium by identifying proteins associated with delirium from unbiased proteomics and combining them with delirium biomarkers identified in our prior work (interleukin [IL]-6 and IL-2). We used the Successful Aging after Elective Surgery (SAGES) Study of adults age ≥70 undergoing major noncardiac surgery (N = 560; 24% delirium). Plasma was collected preoperatively (PREOP) and on postoperative day 2 (POD2). In a nested matched case-control study involving 12 pairs of delirium cases and no-delirium controls, isobaric tags for relative and absolute quantitation-based (iTRAQ) mass spectrometry proteomics was applied to identify the top set of delirium-related proteins. With these proteins, we then conducted enzyme-linked immunosorbent assay (ELISA) confirmation, and if confirmed, ELISA validation in 75 matched pairs. Multi-marker conditional logistic regression was used to select the "best" PREOP and POD2 models for delirium. We identified three proteins from iTRAQ: C-reactive protein (CRP), zinc alpha-2 glycoprotein (AZGP1), and alpha-1 antichymotrypsin (SERPINA3). The "best" multi-protein models of delirium included: PREOP: CRP and AZGP1 (Bayesian information criteria [BIC]: 93.82, c-statistic: 0.77); and POD2: IL-6, IL-2, and CRP (BIC: 87.11, c-statistic: 0.84). The signature of postoperative delirium is dynamic, with some proteins important before surgery (risk markers) and others at the time of delirium (disease markers). Our dynamic, multi-protein signature for delirium improves our understanding of delirium pathophysiology and may identify patients at-risk of this devastating disorder that threatens independence of older adults.

A commercial vinegar product (ChinKiang) was found to be highly attractive to adult house flies, Musca domestica L. Field experiments on a Nebraska dairy demonstrated that traps baited with vinegar and brown sugar captured more house flies than those baited with other house fly attractants. Solid phase microextraction was used in the field to collect volatiles from the vinegar bait. Seven compounds were identified as, acetic acid, furfural, butanoic acid, isovaleric acid, hexanoic acid, 2-phenylethanol, and p-cresol. Electroantennograms showed that the seven vinegar components elicited significant responses from antennae of female and male house flies. Bioassays indicated that the vinegar blend of the seven volatile components were more attractive than any of the individual components. Field evaluations demonstrated that traps baited with the synthetic seven component blend caught as many flies as those baited with vinegar. This is the first detailed report of house fly attractants from vinegar. The vinegar volatile compounds identified in this study will be useful for the development of less objectionable alternatives to the fetid, manure mimicking volatiles currently used in commercial fly bait systems, especially those designed for use in indoor environments.

Research Article| October 01, 1977 Eastern Piedmont fault system: Speculations on its extent Robert D. Hatcher, Jr.; Robert D. Hatcher, Jr. 1Geology Department, Clemson University, Clemson, South Carolina 29631 Search for other works by this author on: GSW Google Scholar David E. Howell; David E. Howell 2South Carolina State Development Board, Division of Geology, Harbison Forest Road, Columbia, South Carolina 29210 Search for other works by this author on: GSW Google Scholar Pradeep Talwani Pradeep Talwani 3Department of Geology, University of South Carolina, Columbia, South Carolina 29208 Search for other works by this author on: GSW Google Scholar Author and Article Information Robert D. Hatcher, Jr. 1Geology Department, Clemson University, Clemson, South Carolina 29631 David E. Howell 2South Carolina State Development Board, Division of Geology, Harbison Forest Road, Columbia, South Carolina 29210 Pradeep Talwani 3Department of Geology, University of South Carolina, Columbia, South Carolina 29208 Publisher: Geological Society of America Received: 16 Jun 1977 Accepted: 07 Jul 1977 First Online: 02 Jun 2017 Online ISSN: 1943-2682 Print ISSN: 0091-7613 Geological Society of America Geology (1977) 5 (10): 636–640. https://doi.org/10.1130/0091-7613(1977)5<636:EPFSSO>2.0.CO;2 Article history Received: 16 Jun 1977 Accepted: 07 Jul 1977 First Online: 02 Jun 2017 Cite View This Citation Add to Citation Manager Share Icon Share Facebook Twitter LinkedIn MailTo Tools Icon Tools Get Permissions Search Site Citation Robert D. Hatcher, David E. Howell, Pradeep Talwani; Eastern Piedmont fault system: Speculations on its extent. Geology 1977;; 5 (10): 636–640. doi: https://doi.org/10.1130/0091-7613(1977)5<636:EPFSSO>2.0.CO;2 Download citation file: Ris (Zotero) Refmanager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentBy SocietyGeology Search Advanced Search Abstract Geologic mapping, interpretation, and field checking of recent aeromagnetic data suggest the existence of a closely associated series of faults and splays extending from Alabama to Virginia, herein termed the Eastern Piedmont fault system. Characteristic magnetic anomalies were found to be associated with known faults and were used to trace them through covered intervals. The fault system extends northeastward from the Goat Rock fault of Alabama and west-central Georgia, crossing the lower Piedmont of South Carolina, passes beneath a segment of the Coastal Plains in the Carolinas, and then flanks the Raleigh belt in North Carolina and continues into Virginia. From east-central Georgia to Virginia, cataclastic rocks along the faults of the system are bounded to the northwest and southeast by rocks of the Carolina slate belt, forming perhaps the most extensive fault system in eastern North America. Its movement history is similar to that of the Brevard fault: an early ductile mylonitic phase, followed by periods of brittle deformation. We interpret the fault system to have been initiated during collapse of the late Precambrian–early Paleozoic Carolina slate belt island arc. The Paleozoic continental suture probably lies farther east, buried beneath the Coastal Plain. First Page Preview Close Modal You do not have access to this content, please speak to your institutional administrator if you feel you should have access.