Barnstorm Research (United States)

Abstract BackgroundLomecel‐B is a novel cell‐based therapy with potential to demonstrate clinical benefit on Alzheimer’s disease (AD) and its progression. Here we present the results of a phase 2a proof‐of‐concept trial (n = 49) to further define the potential of Lomecel‐B in patients with mild AD dementia.MethodsThis double‐blind, randomized, placebo‐controlled 45‐week trial (ClinicalTrials.gov: NCT05233774) enrolled patients (60‐85 yrs.) with mild AD dementia (MMSE score 18‐24); with evidence of amyloid on positron‐emission tomography (PET) and brain MRI consistent with AD. There were 4 study arms of Lomecel‐B intravenous infusion: 25 million (25M) cells once followed by 3 infusions of placebo (N = 13); 25 million (25M) cells (N = 13) or 100 million (100M) cells (N = 11) monthly for 4 months; 4 IV infusions of Placebo (N = 12). The primary endpoint was safety, secondary endpoint was change from baseline to Week 39 in Composite AD Score (CADS) that equally incorporated z‐scores of CDR‐SB, ADAS‐Cog‐13, ADCS‐ADL, and left hippocampal volume.ResultsThe trial achieved its primary endpoint of safety and tolerability (no infusion‐related reactions, ARIA or death). One SAE occurred within 30 days post‐infusion for each Lomecel‐B group with none for placebo. Lomecel‐B 25Mx1 demonstrated a trend toward slowing of disease progression relative to placebo on the CADS score (0.38 [‐0.06, 0.82], p = 0.091 (pre‐specified level of significance for CADS is p = 0.1)). While CADS declined by ‐0.25 [95% CI, ‐0.56, 0.07] in placebo, no decline occurred in the individual or pooled Lomecel‐B treatment groups. Regarding cognitive function, MoCA improved vs placebo (25Mx1: (4.90 [95% CI, 1.26, 8.55], p = 0.009) and (pooled: 3.74 [95% CI, 0.73, 6.75] p = 0.015). ADRQL and QOL‐AD were numerically improved in Lomecel‐B treatments; with significant improvement observed in the ADCS‐ADL for the 100M×1 (10.74 [95% CI, 0.50, 20.98] p = 0.040) and pooled group at Week 39 p = 0.047). Lomecel‐B slowed whole brain volume loss by 49% (100Mx4 (8.31 [95% CI, 0.12, 16.50] p = 0.034) with significant preservation of left hippocampal volume (pooled: 0.0253 [95% CI, 0.0015, 0.0492] p = 0.038), Week 39 compared to placebo.ConclusionTogether, the study achieved proof‐of‐concept in a small sample size. Accordingly, these findings support further development of Lomecel‐B in a larger dose‐finding study.

Wētā FX's Senior VFX Supervisors Joe Letteri and Eric Saindon, Pre-Production Supervisor Marco Revelant, FX Supervisor Nick Illingworth will be joined by Lightstorm Entertainment's VFX Supervisor Richard Baneham to discuss the VFX for this award-winning film.

We compare and contrast the effectiveness of a set of adaptive and non-adaptive algorithms for isotope identi cation based on gamma-ray spectra. One dimensional energy spectra are simulated for a variety of dwell-times and source to detector distances in order to reflect conditions typically encountered in radiological emergency response and environmental monitoring applications. We nd that adaptive methods are more accurate and computationally efficient than non-adaptive in cases of operational interest.

The Paton Welding Journal, 2014, №10. International Scientific-Technical and Production Journal «The Paton Welding Journal» «The Paton Welding Journal» has been published monthly since 2000 in English, ISSN 0957-798X. «The Paton Welding Journal» is a cover-to-cover English translation of the «Avtomaticheskaya Svarka» (Automatic Welding) journal. The «Avtomaticheskaya Svarka» journal has been published monthly since 1948 in Russian, ISSN 005-111X.

Abstract Declining Productivity Index, as considered herein, is a productivity indexthat has a substantially and consistently decreasing value when measured over aperiod of a few hours. If not recognized, it may be interpreted as representingan unsettled or unstable condition in a producing well. It forms the basis of anumber of predictions as to future performance compared with the performance ofwells in which the productivity index does not decline. The most important ofthese are that:the rate of oil production will decline more rapidly,the gas-oil ratio will usually increase abnormally,the amount of waterultimately produced will be negligible, if any,stop-cocking will increase current production and decrease gas-oil ratio. When such relative well performance is indicated, it follows that certain reservoir performance andoperating practices may be anticipated:disappointing recovery,longernatural flow,no active water drive,better evaluation of acidizing, shooting and reworking,intermittent operation of wells,smallerpumping equipment required. It is significant that the basis of these importantpredictions is bottom hole pressure tests that can be made immediately aftercompletion of the wells. Introduction "Productivity index" is the number of barrels of oil produced per dayper pound per square inch of differential pressure between the reservoir andthe bottom of the well. ?Declining Productivity Index," as consideredherein, is a productivity index that has a substantially and consistentlydecreasing value when measured over a period of a few hours. Productivity index can be determined only when the rate of production can bestabilized. In most wells the rate of production and bottom-hole pressure ateeasily stabilized to give a constant productivity index for a period of manyhours. A few produce so erratically as to preclude probability of an acceptabletest in the usual sense. A satisfactory productivity index can be determined insome wells only by gauging the production accurately by hours, measuring thebottom-hole pressure continuously, and from these data calculating theproductivity index for successive hours. Such figures frequently will have adecreasing value-that is, a declining productivity index-and when plotted ondouble logarithmic cross-section paper with productivity index as ordinate andtime as abscissa will be a straight line curve. The angle between the curve andthe abscissa is referred to as the rate of decline. Declining productivity index may appear to be the result of change inpermeability to oil due to decreasing saturation of oil and increasingsaturation of gas in the reservoir. T.P. 1872