Beroendecentrum Stockholm

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Abstract
1
10.1186/1742-4690-8-s1-a67

HTLV-2 infection still prevalent among older injecting drug users in Stockholm, Sweden – indications of limited spread to the younger generation

Jun 06, 2011
Retrovirology
Kerstin Malm + 3 more +3

Results Among 1079 investigated subjects, 35 were found to be positive for antibodies to HTLV-1 and/or HTLV-2, giving an overall HTLV-prevalence of 3.2%. Of these, 2 (0.2%) had antibodies to HTLV-1, 28 to HTLV-2 (2.6%) and 5 (0.5%) had non-typeable antibodies to HTLV. The overall study group had similar age and sex distribution as in 1995. However, the HTLV-positive individuals were 10 years older than the HTLV-negative group (mean age) and compared to the cases studied in 1995.

Research Article

The ancient roots of psychiatry. Ancient literature, philosophy and medicine put the basis of the current specialty

Apr 22, 2004
Lakartidningen
Lars Sjöstrand

Book Chapter
10.1007/978-3-642-96008-6_4

5-HTOL is a sensitive marker of recent alcohol consumption

Jan 01, 2001
Stefan Borg + 1 more +1

Increased 5-hydroxytryptophol (5-HTOL) — a natural constituent of human urine — can be used as a marker of recent alcohol consumption. It is formed in the body as a metabolite of serotonin (5-hydroxytryptamine, or 5-HT) and is excreted in urine after conjugation with glucuronic acid (Bosin, 1978). The catabolic pathway of serotonin consists of oxidative deamination to 5-hydroxyindole-3-acetaldehyde (5-HIAL) by the enzyme monoamine oxidase (EC1.4.3.4). 5-HIAL is then either oxidazed by aldehyde dehydrogenase (EC 1.2.1.3) to form 5-hydroxyindole-3-acetic acid (5-HIAA) or reduced by alcohol dehydrogenase (EC 1.1.1.1) or aldehyde reductase (EC 1.1.1.2) to form 5-HTOL, see figure 1.