Beta Technology Limited

The integration between business and society is a priority in the current business world, and it is an emergent area of research in the extant literature. Business organizations are pursuing the interdependency between business and society using business ethics, corporate social responsibility, and shared value. Stakeholder orientation is the cornerstone of these new initiatives and it is growing in the future. Therefore, this paper intends to explain the nature of a stakeholder-oriented business organization with its contribution to social value creation. Based on interpretivism, researchers adopted a qualitative embedded single case study design methodology. The organization under study is a small scale manufacturing company in Kandy working with multiple stakeholders. Data was collected using secondary sources and by conducting in-depth interviews with the owner of the company, self-employed rural artisans and entrepreneurial suppliers who were selected using a judgmental sampling method. Data analysis involves transcription, summary and keyword development. The final stage of the analysis was conducted by cross-tab analysis and interview findings are even analyzed using discourse analysis. As per the analysis, the company has shown that a stakeholder-oriented business approach maintains a strong relationship with stakeholders by focusing on multiple stakeholder interests and deep stakeholder understanding. The company works collaboratively with rural artisans, private sector organizations and small scale entrepreneurial suppliers. The continuous stakeholder dialogue is a salient feature in this business approach. Social value creation of stakeholder orientation was evidenced through income enhancement, improvement in living conditions, citizenship enhancement and social capital development. Further, the feeling of engagement in work and supporting the education of the children also emerge in the data as social value creations. Researchers contend that it is important to uncover each stakeholder’s unique social issues in social value creation and conclude that connectivity can be created between a business organization and social issues through stakeholder orientation.

Can I get hold of the data? Where can I find out more? 
\nThe project is co-ordinated by the Centre for Life Course Health Research and the Northern Finland Cohort Project Centre at the University of Oulu in Finland. Further details on DynaHEALTH are available from the website: www.dynahealth.eu. The studies are approved by the local institutional review boards. Written informed consent has been obtained for participants. There is no central repository for the data and each participating cohort has its own policy for data sharing.
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\nThe DynaHEALTH project legacy will be a collaborative action that will invite researchers with longitudinal life-course data to engage with us via the website (https://www.dynahealth.eu/contact). To ensure continuity, the relevant section of the website and a light governance will remain to bring sustainability to the consortium and support the testing of its scientific concept.

Rapamycin is an important macrocyclic polyketide produced by Streptomyces hygroscopicus and showing immunosuppressive, antifungal, and antitumor activities as well as displaying anti-inflammatory and neuroregenerative properties. The immense pharmacological potential of rapamycin has led to the production of an array of analogues, including through genetic engineering of the rapamycin biosynthetic gene cluster. This cluster contains several putative regulatory genes. Based on DNA sequence analysis, the products of genes rapH and rapG showed high similarities with two different families of transcriptional activators, LAL and AraC, respectively. Overexpression of either gene resulted in a substantial increase in rapamycin biosynthesis, confirming their positive regulatory role, while deletion of both from the chromosome of S. hygroscopicus resulted in a complete loss of antibiotic production. Complementation studies indicated an essential role of the RapG regulator for rapamycin biosynthesis and a supportive role of RapH. A direct effect of rapH and rapG gene products on the promoter of the rapamycin polyketide synthase operon, rapA-rapB, was observed using the chalcone synthase gene rppA as a reporter system.