Bioinstitut

Tadqiqotda probiotiklar bilan oziqlantirilgan quyonlarda fagotsitar faollik, lizotsim darajasi, qon zardobining bakteritsid faolligi ko‘rsatkichlari baholandi. Natijalar probiotiklar ichak mikrobiotasini me’yorlashtirib, immun tizim faoliyatini kuchaytirishini ko‘rsatdi. Probiotiklar ta’sirida infeksiyalarga chidamlilik oshdi, stressga moslashuv yaxshilandi va kasallanish holatlari kamaydi. Tadqiqot xulosalari quyonchilikda sog‘lom, ekologik xavfsiz oziqlantirishni joriy etish, antibiotiklardan foydalanishni kamaytirish, mahsuldorlikni oshirish hamda hayvonlar sog‘lig‘ini mustahkamlashda muhim ilmiy-amaliy ahamiyatga ega ekanini isbotlaydi, chorvachilikda probiotiklardan foydalanish istiqbolli yo‘nalish ekanini asoslaydi, amaliyotda keng qo‘llashni tavsiya etadi. Hayvonlar tomonidan iste’mol qilinadigan ozuqasi tarkibiga qo‘shib beriladigan ProBioKorm va Maxlac probiotik bakteriyalar asosida yaratilgan ozuqa qo‘shimchasidir. Bu unversal oziqabop qo‘shimcha ozuqa sifatini yaxshilaydi va moddalarning hazm bo‘lishi va so‘rililishini yaxshilaydi, hayvonlarning turli bakterial kasalliklarini oldini oladi va davolaydi , mahsuldorligini oshiradi.

This study explores the virome of fifteen peanut cultivars in Korea. Through RNA sequencing, 305 viral contigs associated with cucumber mosaic virus (CMV), peanut mottle virus (PeMoV), bean common mosaic virus (BCMV), and brassica yellows virus (BrYV) were identified, with CMV notably prevalent across samples. Evaluation of viral abundance using viral reads and TPM values revealed CMV dominance in reads and PeMoV prominence in normalized values in select samples. Complete genomes of BCMV, PeMoV, BrYV, and CMV segments were assembled, enabling phylogenetic analysis that uncovered genetic relationships among viral isolates. RT-PCR confirmed BCMV, CMV, and PeMoV presence. Genetic diversity within BCMV was evident through single-nucleotide polymorphism (SNP) analysis, displaying diverse patterns and correlations with viral reads. This study discusses the implications for peanut cultivation, stressing the importance of ongoing research to manage viral diseases. It forms a foundational resource for future investigations into peanut virology, guiding strategies for disease management in peanut crops.

The outbreak of Covid-19 pandemic in Kenya in the year 2020 triggered a massive infodemic campaigns by the Kenyan government to raise public awareness about the disease. There was an overabundance of information globally about Covid-19 and the risk of misinformation and disinformation was very high. Although the masses were craving for news about the disease it was not easy to identify the trustworthy sources and reliable health guidance. This information confusion undermined the efforts to curb the spread of the Covid-19 pandemic. Recognizing the power of mass media contents in shaping public opinion, this article examined the use of the caricature as a platform of communication. It specifically analyzed how the Kenyan newspapers’ used caricatures and satirical techniques to deploy the World Health Organization’s Health Taxonomy for Social Listening frames in their Covid-19 messages. It uses the coinage satiricalization to emphasize the extent to which the caricatures deployed humour, mockery and infotainments to deliver their messages. To interpret and make sense of the caricatures’ messages, multimodal critical discourse analysis and content analysis were deployed. 261 caricatures were evaluated. The Key finding was that the three newspapers of Nation, Standard and the Star deployed caricatures as potent tools for communication and that, the WHO’s taxonomy of health messaging is a strategic asset that is used by cartoonists in their framing of health messages. It is recommended that, print media outlets in Kenya should continue using caricatures in their priming of key issues that affects the society.

ABSTRACT In humans, 19 Wnt ligands interact with 10 Frizzled (Fzd) receptors and the co-receptors LRP5/6 to initiate signaling. Wnts and Fzds are highly promiscuous, making it challenging to dissect the specific outcomes of individual Wnt-Fzd interactions. Developing Wnt surrogates with specificity for individual Fzd subtypes could be pivotal. We present a modular, potent, and Fzd7-specific Wnt surrogate that consists of three de novo designed modules, a Fzd7 binder, an LRP6 binder and a homodimeric protein. The Fzd7-specific module was designed by targeting two less conserved surface patches on the cysteine-rich domain (CRD) of Fzds to achieve both selectivity and affinity. It exhibits a strong binding affinity (K D < 2.3 nM) for the very closely related Fzd7 subtype members (Fzd7, Fzd1, Fzd2) with no measurable binding to the CRDs of the other seven Fzd receptors. This Wnt surrogate induced spheroid organoid formation from intestinal stem cells at subnanomolar concentration, and promoted full hair follicle regeneration and robust hair growth in mice. These results suggest that our strategy could be extended to design modular Wnt surrogates capable of selectively activating individual Fzd receptors, providing a valuable tool kit for development and differentiation, organoid cultures and targeted regeneration.

Kegiatan perawatan berupa program reliability pada pesawat udara dilakukan untuk menjaga keandalan komponen pesawat serta menjaga kondisi pesawat udara agar tetap laik terbang dan meminimalisir kegagalan yang dapat mengakibatkan penurunan performa pada keseluruhan sistem tersebut. Berdasarkan data defect report helikopter EC 155 B1 Eurocopter, dilakukan penerapan program reliability dari tahun 2011-2023 dan ditemukan bahwasanya ada beberapa komponen yang mengalami kegagalan pada ATA Chapter 32 (Landing Gear). Penelitian ini menggunakan metode Failure Mode Effect Analysis (FMEA). Hasil dari penelitian menunjukkan program reliability yang diterapkan memiliki faktor deviasi bernilai 3.2 dalam perhitungan dengan interval 12 bulan. Berdasarkan dari data defect report didapatkan 5 modus kegagalan terkait ATA Chapter 32 (Landing Gear). Dari hasil analisa dengan metode FMEA dari 5 jenis permasalahan terkait ATA Chapter 32 (Landing Gear) didapatkan permasalahan pada Brake Accumulator memiliki nilai RPN paling tertinggi yaitu sebesar 36 yang mana merupakan tingkat kegagalan yang rendah.

Sistem resirkulasi AC merupakan sub sistem pada sistem pendingin udara yang berfungsi untuk mensirkulasikan dan menyaring 50% udara yang ada di dalam kabin sehingga penumpang terhindar dari berbagai macam polusi, virus, bakteri dan debu yang dapat memicu iritasi pada manusia seperti seperti hidung tersumbat, mata berair, dan pilek. Berdasarkan hasil data kerusakan yang penulis ambil pada maskapai XYZ pada tahun 2016 – 2019, kerusakan pada sistem resirkulasi AC pada komponen kipas angin cukup tinggi dengan kerusakan sebesar 21 kali lipat. Dimana damage yang paling dominan adalah kipas pop out sebanyak 5 kali dan kipas tidak berfungsi sebanyak 4 kali. Tahap penelitian ini diawali dengan penentuan komponen kritis menggunakan metode analisis kekritisan dengan menghitung empat kriteria dimana terdapat frekuensi kerusakan yang tinggi, dampak kerusakan pada sub perakitan, sulitnya pelepasan dan pemasangan serta harga yang mahal dan analisis ABC. , lalu menentukan nilai TTF dan TTR komponen. Setelah itu identifikasi kerusakan yang sering terjadi pada komponen kritis sistem resirkulasi AC. Berdasarkan hasil pengolahan data yang telah dilakukan, komponen yang paling kritis adalah komponen kipas angin dengan nilai nilai 32. Selanjutnya berdasarkan hasil identifikasi kerusakan terdapat 9 jenis kerusakan yang sering terjadi pada komponen kipas yaitu pop out, aliran rendah, kondisi buruk, motor rusak, berisik, tidak berfungsi, putaran tidak stabil, tidak berputar dan lemah. Dimana damage yang paling dominan adalah kipas pop out sebanyak 5 kali dan kipas tidak berfungsi sebanyak 4 kali.

Indonesia holds the third position in global coffee bean supply, with a 3.3% increase in demand in 2021 according to ICO data. In line with ICO Resolution 407, coffee bean quality must be high, indicated by a 12.5% moisture content through drying processes. Mechanical drying is faster than traditional methods, thus becoming the focus of this research. This study implements an IoT-based monitoring system for coffee bean drying equipment. The aim is to create and implement a monitoring system for temperature (0°C - 70°C) and electrical energy consumption (kWh) in coffee bean drying, displayed on the ThingSpeak dashboard. Test results show that the temperature monitoring system using DHT22 sensors at the inlet and outlet of the rotary dryer tube has an average error of 2.1%. The energy monitoring system using PZEM-004T has a 0% energy measurement error. These results indicate a reliable monitoring system that enables remote monitoring via the internet. Furthermore, the study tests manual (on/off) and fuzzy logic control methods to achieve 12% moisture content in coffee beans. The fuzzy logic control method demonstrates better temperature stability and 11.2% cost savings in operational expenses. This research benefits coffee farmers by facilitating efficient monitoring of the bean drying process, and recommends the use of the fuzzy logic control method for stable temperature and lower operational costs.

Varaždin pumpkin seed oil is a virgin edible oil obtained by roasting and mechanically pressing dry pumpkin seeds (Cucurbita pepo L.). The aroma is dominated by a sense of toastiness interwoven with a specific nutty taste without any foreign or rancid smell or taste. It is dark green to black in colour with a reddish glow. It is characterized by fragrant, spicy notes and a well-balanced bouquet. The basic quality chemical parameters of Varaždin pumpkin seed oil monitored over the past eight years show that the proportion of free fatty acids (expressed as oleic) is less than 1%, which indicates good quality of the raw material and the applied oil production technology. The peroxide value is less than 4 mmol O2/kg, which is an indicator of good oxidation stability of the oil during its storage. The average value of the representation of unsaturated fatty acids is more than 80%, and variations in the fatty acid composition are the result of specific climatic conditions occuring in the year of growing and harvesting pumpkins.

Ketepatan waktu Maintenance merupakan upaya perusahaan dalam pemenuhan kebutuhan dan keinginan konsumen agar pesawat mereka dapat melayani penumpang sesuai dengan waktu yang telah ditentukan. PT. GMF AeroAsia merupakan salah satu perusahaan yang bergerak dibidang jasa pemeliharaan, perbaikan, dan perawatan pesawat terbang. Ketepatan waktu perawatan mesin pesawat terkadang masih sering terjadi keterlambatan khususnya pada bagian pemasangan atau Assembly Engine sehingga perlu adanya dilakukan perbaikan. Tujuan dari penelitian ini untuk menganalisis dan mengetahui faktor penyebab keterlambatan proses Engine Maintenance pada bagian Assembly Core External Engine. Maka, untuk mengatasi masalah tersebut digunakan metode Six Sigma. Dari hasil perhitungan, didapatkan nilai sigma sebelum perbaikan sebesar 2,4σ dan nilai capability process sebesar 0,8 yang menandakan sering terjadi Delay. Setelah dilakukan perbaikan, nilai sigma yang diperoleh sebesar 3,04σ dan nilai Capability Process sebesar 1,01 yang menandakan bahwa usulan perbaikan yang dilakukan berdampak positif terhadap pengurangan Delay.

Praktek kerja lapangan merupakan sarana bagi mahasiswa untuk mendapatkan pengalaman kerja di industri. Namun, dimasa pandemic Covid-19, beberapa perusahaan tidak dapat menerima mahasiswa secara langsung. Disisi lain, sebagian fresh graduate masih belum mendapatkan tempat kerja yang sesuai harapan. Pengabdian kepada masyarakat ini bertujuan memberikan edukasi tentang aplikasi UAV (unmanned aerial vehicles) di industri, Avionic dan dunia kerja kepada mahasiswa dan alumni Teknik Elektro Institut Teknologi Dirgantara Adisutjipto. Pengabdian masyarakat dilakukan dalam bentuk webinar melalui media zoom meeting dan dapat diikuti oleh masyarakat umum. Untuk mendapatkan umpan balik peserta, tim pengabdian menggunakan kuesioner yang dibagikan kepada peserta. Peserta cukup antusias untuk mengikuti kegiatan ini selama tiga hari berturut-turut dan dapat menerima materi pengetahuan yang diberikan oleh pemateri. Berdasarkan data kuesioner, kegiatan ini dapat meningkatkan pengetahuan dan wawasan peserta tentang aplikasi UAV, Avionic dan dunia kerja Teknik Elektro.