Bioservo Technologies (Sweden)

The microgravity environment aboard the International Space Station (ISS) provides a unique stressor that can help understand underlying cellular and molecular drivers of pathological changes observed in astronauts with the ultimate goals of developing strategies to enable long-term spaceflight and better treatment of diseases on Earth. We used this unique environment to evaluate the effects of microgravity on kidney proximal tubule epithelial cell (PTEC) response to serum exposure and vitamin D biotransformation capacity. To test if microgravity alters the pathologic response of the proximal tubule to serum exposure, we treated PTECs cultured in a microphysiological system (PT-MPS) with human serum and measured biomarkers of toxicity and inflammation (KIM-1 and IL-6) and conducted global transcriptomics via RNAseq on cells undergoing flight (microgravity) and respective controls (ground). We also treated 3D cultured PTECs with 25(OH)D3 (vitamin D) and monitored vitamin D metabolite formation, conducted global transcriptomics via RNAseq, and evaluated transcript expression of CYP27B1, CYP24A1, or CYP3A5 in PTECs undergoing flight (microgravity) and respective ground controls. We demonstrated that microgravity neither altered PTEC metabolism of vitamin D nor did it induce a unique response of PTECs to human serum, suggesting that these fundamental biochemical pathways in the kidney proximal tubule are not significantly altered by short-term exposure to microgravity. Given the prospect of extended spaceflight, more study is needed to determine if these responses are consistent with extended (> 6 month) exposure to microgravity.

Robotics-enabled technologies for assistive and rehabilitative applications have gained an increasing attention, both in academic and industrial research settings, as a promising solution for human sensory-motor system recovery. However, many constraints remain that limit their effective employment in everyday-life, mainly related to cost, usability and users’ acceptance. The Softpro project proposes to completely reverse such paradigm, starting from the analysis of the needs from patients and the careful investigation of the sensory-motor human behaviour, capitalizing on the framework of synergistic control and soft robotics. The final goal is to study and design simple, effective and affordable soft synergy-based robotic technologies for the upper limb, such as new prostheses, exoskeletons, and assistive devices which can be useful and accessible to a wide audience of users. To pursue such an ambitious objective, SoftPro has put together research groups who laid the neuroscientific and technological fundamentals underpinning the project approach, a net of international collaborations and numerous and qualified industrial partners, which is expected to produce a strong impact on both research and innovation.