Biozeen (India)

The study discusses the challenges associated with the HNSCC metastasis and aims to identify hub genes related to the Cancer Stem Cells and metastasis in HNSCC through bioinformatics analysis. HNSCC is a prevalent type of cancer having a low five-year rate of survival, largely due to advanced stages at diagnosis and distant metastasis. The study hypothesizes that CTCs with CSC characteristics are responsible for metastasis. To investigate, we utilized mRNA-based stemness index (mRNAsi) and WGCNA

Health is a vital factor for the proper functioning of the various organs in the human body. Moreover, it is directly associated with the quality of life of humans in their habitats. This central idea of the role of health was persistently emphasized by many biologists and philosophers of ancient times. Eventually, global and national organizations like the World Health Organization (WHO), Centre for Disease Control and Prevention (CDC), National Health Service (NHS), and ICMR (Indian Council of Medical Research), dedicated to monitoring the health and diseases of humans, came to be established. The epidemiology of various human diseases could be traced mainly because of the massive surveillance operations conducted by these organizations. Rational therapeutics, developed after the boom in appropriate diagnostic techniques, successfully replaced irrational treatment elixirs. This chapter dwells on human health and a selection of prognostic and diagnostic procedures for the identification of diseases. The concepts of molecular, biopotential measurement and imaging techniques used in the diagnosis of various diseases and malfunctions are discussed herein. Techniques used for the identification of diseases at the molecular level, biopotential techniques used for recognizing abnormalities in signal transduction within the nervous system and imaging techniques used in the prediction of disease with images generated from affected organs are some of the breakthroughs achieved in the detection of a disease.

ABSTRACTIn this work, two bioflocculants, namely, EB-EPS and B1-EPS, were derived from Enterobacter sp. and Bacillus sp., respectively, and analyzed with regard to their production and characterization. About 0.9 and 0.16 g of purified EB and B1 were obtained from I L of fermentation broth. Chemical analysis showed the contents of purified EB and B1 mainly as 88.7 and 92.8% (w/w) of carbohydrate, and 11.3 and 21.8% (w/w) protein, respectively. Fourier-transform infrared spectrometry analysis revealed the presence of hydroxyl, amide, and carboxyl groups in the identified bioflocculant. Thermogravimetric analysis (TGA) results exhibited enhanced thermal stability with a minimum mass loss of 50% while 25% were found to have occurred at higher temperatures (>400°C) for microbe-derived compounds EB and B1 leading to the possibility of using these compounds as fillers or for fabricating composite films for high-temperature applications. Further, the compounds from both the bacteria exhibited good antibacterial characteristics against pathogenic Escherichia coli. Degradability study of bioflocculant-embedded composite films shows the possibility of attaining eco-friendly bioremediation. Accordingly, experimental results revealed the suitability of developed composite films as a suitable alternative for food packaging and biomedical applications.