- Preprint Article
- 10.2139/ssrn.5553387
Graph Neural Networks in Cancer Genomics: Mapping Mathematical Operations to Biological Insights
- Jan 01, 2025
- SSRN Electronic Journal
- Vatsal Patel + 5 more +5
Publications from 2021 to 2026
Showing 10 of 18 papers
Graph Neural Networks in Cancer Genomics: Mapping Mathematical Operations to Biological Insights
Insect herbivory shapes functional diversity of trees in a tropical mountain biodiversity hotspot
Can America Heal: Framing the Dialectic
On January 20, 2021, Joseph R. Biden, Jr., took the presidential oath of office, becoming the 46th president of the United States in a time of profound division within the fabric of the nation. In his inaugural address, he repeatedly stressed the need for Americans to come together. He drew a stark distinction between unity and division, arguing that the only way we can heal America’s wounds is to coalesce into a tolerant working democracy that can defeat the conditions tearing us apart. He was addressing the nation in the wake of a violent insurgency at the Capitol on January 6, 2021, an act of evil aggression.
Read moreThe effect of transitioning to ICD-10-CM on acute injury surveillance of active duty service members
BackgroundAcute injuries are a burden on the Military Health System and degrade service members’ ability to train and deploy. Long-term injuries contribute to early attrition and increase disability costs. To properly quantify acute injuries and evaluate injury prevention programs, injuries must be accurately coded and documented. This analysis describes how the transition from International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) to the Tenth Revision (ICD-10-CM) impacted acute injury surveillance among active duty (AD) service members.Twelve months of ICD-9-CM and ICD-10-CM coded ambulatory injury encounter records for Army, Navy, Air Force, and Marine Corps AD service members were analyzed to evaluate the effect of ICD-10-CM implementation on acute injury coding. Acute injuries coded with ICD-9-CM and categorized with the Barell matrix were compared to ICD-10-CM coded injuries classified by the proposed Injury Diagnosis Matrix (IDM). Both matrices categorize injuries by the nature of injury and into three levels of specificity for body region, although column and row headings are not identical.ResultsAcute injury distribution between the two matrices was generally similar in the broader body region categories but diverged substantially at the most granular cell level. The proportion of Level 1 Spine and back Body Region diagnoses was higher in the Barell than in the IDM (6.8% and 2.3%, respectively). Unspecified Level 3 Lower extremity injuries were markedly lower in the IDM compared to the Barell (0.1% and 12.1%, respectively).ConclusionsThis is the first large scale analysis evaluating the impacts of ICD-10-CM implementation on acute injury surveillance using ambulatory encounter data. Some injury diagnoses appeared to have shifted to a different chapter of the codebook. Also, it’s likely that the more detailed diagnostic descriptions and episode of care codes in ICD-10-CM discouraged re-coding of initial acute injury diagnoses.The proposed IDM did not result in a major disruption of acute injury surveillance. However, many acute injury diagnosis codes cannot be aligned between ICD versions. Overall, the increased specificity of ICD-10-CM and use of the IDM may lead to more precise acute injury surveillance and tailored prevention programs, which may result in less chronic injury, reduced morbidity, and lower health-care costs.
Read moreThe Racial Imagination of the Lindy Hop from the Historical Standpoint – Comments and Corrections
A book review with comments and corrections from the historical standpoint. The review concerns Dr. Black Hawk Hancock's American Allegory: Lindy Hop and the Racial Imagination (Chicago, IL, University of Chicago Press. 2013).
Read moreStrategies for increasing the yield potential of cereals: case of rice as an example
Abstract Rice is the most important food crop. Worldwide, more than 3.5 billion people depend upon rice for more than 20% of their calories. Global rice demand is estimated to rise from 676 million tons in 2010 to 763 million tons in 2020 and to further increase to 852 million tons in 2035. This is an overall increase of 176 million tons in the next 25 years. To meet this challenge rice production on existing land must be increased. Grain production is largely influenced by the yield potential of rice varieties. Therefore, improvement in the yield potential of rice is the major strategy to increase world rice production. Various strategies to increase the yield potential include; (1) conventional hybridization and selection, (2) ideotype breeding, (3) hybrid breeding, (4) exploitation of wild species germplasm, (5) enhancement of photosynthesis, (6) genomic approaches and (7) physiological approaches. Rice has become a model plant for genetics and breeding research. Advances in molecular biology and genomics, proteomics and metabolics have opened new avenues to apply innovative approaches to rice breeding. Molecular‐assisted selection (MAS) has become an integral component of germplasm improvement. A large number of genes/QTLs for various traits have been tagged with molecular markers to apply MAS for trait improvement. Genome sequence data have become an important source for detecting allelic variation. It is now possible to precisely understand the role of epigenetic changes in gene expression, thus understanding the stability of various stresses under changing environments. All these advances when integrated with conventional breeding will result in designer rice varieties to meet the challenges of rice food security in 21th century.
Read moreIntegration of the mammalian shoulder girdle within populations and over evolutionary time
Morphological integration has the potential to link morphological variation within populations with morphological evolution among species. This study begins to investigate this link by comparing integration among shoulder girdle elements (e.g. scapular blade, glenoid, coracoid, etc.) during the origin and evolution of therian mammals, and within modern bat, opossum and mouse populations. In this study, correlations among skeletal elements and patterns of allometry are used as proxies for integration. Results suggest that shoulder girdle elements tended to vary and evolve independently during the origin of mammals and subsequent radiation of placentals, consistent with the elements' distinct developmental and evolutionary origins. This finding suggests that skeletal element correlations, and therefore integration, can be conserved over large taxonomic and temporal scales. However, marsupials display a different pattern in which shoulder girdle elements tend to be more integrated, with the exception of the coracoid. This finding is consistent with a shift in the pattern of skeletal element integration coincident with the appearance of the marsupial mode of reproduction. This finding provides further evidence that development can play a significant role in the establishment of patterns of skeletal element correlation and that patterns of skeletal element correlation can themselves evolve when faced with sufficient selective pressures.
Read moreDual-mode Analytical Permeation System for Precise Evaluation of Porous and Nonporous Chemical Protective Materials
Higher BMI Values Predicts Higher College-Oriented Eating Disorder Screen (COEDS) Scores in a Small Group of Community College Students
Context of Career Decisions: Women Reared in a Rural Community
This study investigated the influences on the career decisions of women who grew up in a rural community. Forty women were interviewed who graduated in the upper 10% of their high school classes in the 1950s, ‘60s, ‘70s, and ‘80s. The results are described in three components: gender role beliefs, factors, and contexts. Gender role beliefs were the most pervasive influences found. Other factors were (a) information, (b) meeting others' expectations, (c) barriers, (d) sense of empowerment, (e) conditions of work, and (f) personal values. The participants were also affected by their social and historical contexts and their development stages.
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