Blue Sky Research (United States)

ObjectiveTo describe associations between abnormalities in splenic tissue removed secondary to gastric dilatation-volvulus (GDV) correction and histopathologic diagnosis of splenic malignancy.MethodsDogs treated with splenectomy secondary to GDV correction at any of 83 US veterinary referral hospitals between January 1, 2013 and May 1, 2025 were retrospectively reviewed. Data related to signalment, visual, and tactile description of the spleen during surgery, and results from the splenic histopathology report were recorded. Descriptive statistics were used to summarize histopathologic diagnoses. Frequency proportions were estimated with 95% binomial confidence intervals.ResultsOne hundred thirty-eight dogs were included. The median (range) weight was 31.5 (6–99.7) kg; the median (range) age was 10.1 (1.6–15.1) years. Malignancy was diagnosed in 15 of 138 (10.9%; 95% CI: 6.2%−17.3%) dogs. The prevalence of splenic malignancy did not differ significantly across age or weight quartiles. Malignancy rates significantly differed by the number of visible lesions in the spleen. There were no (0%; 95% CI: 0.0%−7.7%) malignancies in 46 dogs without visible splenic lesions, 13 (19.1%; 95% CI: 10.6%−30.5%) malignancies in 68 dogs with solitary/single visible lesions, 2 (14.3%; 95% CI: 1.8%−42.8%) malignancies in 14 dogs with two visible lesions, and 0 (0%; 95% CI: 0.0%−30.8%) malignancies in 10 dogs with 3 or more visible splenic lesions.ConclusionThe number of lesions in spleens removed secondary to GDV correction was associated with identification of splenic malignancy.Clinical relevanceThe financial cost associated with splenic histopathology following splenectomy secondary to GDV correction may be warranted in spleens with one or two discrete masses.

Copernicus Ground-Based Observations for Validation (GBOV) is a project funded by the European Commission and is part of the Copernicus Land Monitoring Service (CLMS). The project has two main purposes: to support yearly validation efforts of core CLMS products (BRF, Albedo, FAPAR, LAI, FCOVER, LST, Soil Moisture, GPP, NPP, LSP and Evapotranspiration), five of which are listed among GCOS Essential Climate Variables (ECV); and to maintain a data portal making these validation products available. GBOV has reached a broad user community, with about 1700 users, including ESA optical MPC.A large number of ground-based measurement networks disseminate publicly available data such as NEON, ICOS, TERN, BSRN and ISMN. Within GBOV, long-term datasets are needed in order to maximise the number of matchups between ground-based measurements and satellite data.GBOV produces both ground-based, point-scale observations (the so-called “Reference Measurements”), and Analysis Ready Validation Data (ARVD) which are spatially upscaled to match the resolution of CLMS products (the so-called “Land Products”). Those GBOV products cover more than 150 sites and are made available to the community via a data portal freely accessible on https://gbov.land.copernicus.eu/. Available Land Products variables include Surface Bi-directional Reflectance Factors (BRFs), Surface Albedo, Leaf Area Index (LAI), Fraction of Absorbed Photosynthetically Available Radiation (FAPAR), Fraction of Vegetation Cover (FCover), Land Surface Temperature (LST), Surface Soil Moisture (SSM). Gross Primary Production (GPP), Net Primary Production (NPP), Land Surface Phenology (LSP) and Evapotranspiration are new products and are not yet available, their release is planned for the end of 2026.The networks providing GBOV initial input data are unfortunately not evenly distributed. In an attempt to reduce the thematic and geographical gaps, GBOV is developing its own network as part of a collaboration with existing networks. In GBOV phase 1, six ground stations have been upgraded with additional instrumentation. In GBOV phase 2, two ground stations monitoring vegetation variables have been deployed in 2023, one at the Fuji Hokuroku research station in Japan as part of a collaboration with NIES (National Institute of Environmental Studies) and one in 2024 at the Fontainebleau research station (France) as part of a GBOV/ICOS collaboration. In addition, two LST stations were deployed in Fuji Hokuroku and Litchfield (TERN network Australia) in 2024.Over the past year, several updates have been implemented in the GBOV database to better respond to CLMS and general user requirements. This includes new procedures for specific land cover types in vegetation products, improved uncertainty estimates for soil moisture, and enhanced processing procedures for LST products. Procedures are being developed for the new products: Gross Primary Production, Net Primary Production, Land Surface Phenology and Evapotranspiration.This presentation will focus on the current status of GBOV products and highlight recent developments and evolutions.

Abstract Simple, nimble and wise – we hear the story of this fast?track ultraviolet satellite designed to study stars in the time domain

A linear inhomogeneous equation in a Banach space on the real axis, solved with respect to the fractional Liouville derivative, with a bisectorial operator at the unknown function is investigated. The equation is considered without initial conditions. Using the theory of the Fourier transform, the existence of a unique solution to the equation is proved. It is shown that the solution has the form of the convolution of the inverse Fourier transform of the bisectorial operator resolvent and the right-hand side of the equation. Abstract results are applied to study some classes of partial differential equations and systems of equations with a fractional derivative with respect to a selected variable.

Subject of research: is the models and decision support methods in the field of organizational management and IT services and equipment repair production processes.
 Purpose of research: is to analyze existing and create new models, algorithms and technologies for the implementation of a decision support system for the service platform in the field of IT and equipment repair.
 Methods and objects of research: include systems management theory, decision theory, automatic text processing methods, automatic control theory, information systems design theory, optimization theory and object-oriented programming.
 Main results of research: is a prototype aggregator platform, reflecting services in the IT and equipment repair, system architecture, development tools, interface.

BackgroundTraditional management of non‐steroidal anti‐inflammatory drug (NSAID) intoxication includes gastrointestinal decontamination, intravenous administration of fluids (IVF), and gastroprotection. Intravenous administration of lipid emulsion (ILE) and therapeutic plasma exchange (TPE) are popular novel therapeutic strategies.HypothesisCompare outcomes of dogs treated with IVF, ILE, and TPE for NSAID intoxications and evaluate outcome predictors for drug subgroups.AnimalsFour hundred thirty‐four dogs with NSAID intoxications (2015‐2020).MethodsMulticenter retrospective study of ibuprofen, carprofen, and naproxen intoxication. An ordinal outcome was defined as mild gastrointestinal, moderate kidney, or signs of severe central nervous system disease.ResultsSigns of neurological disease were overrepresented and acute kidney injury underrepresented in the TPE group among dogs exposed to kidney‐ or CNS‐toxic doses (P = .05), though all TPE dogs with signs of neurological disease had evidence of neurotoxicity at presentation. Dogs treated with IVF had a higher maximal creatinine concentration (median, 1.1 mg/dL; range, 0.4‐8.44 mg/dL) compared with IVF + ILE (median, 0.9 mg/dL; range, 0.4‐6.2 mg/dL; P = .01). Increased maximum time to presentation (P < .001), higher baseline creatinine (P < .001) and PCV (P = .007), and absence of induced emesis (P < .001) were associated with greater clinical severity. Ibuprofen toxicosis was associated with more severe clinical signs compared with carprofen (P = .03). Overall survival rate was 99%.Conclusions and Clinical ImportanceNSAID toxicosis generally carries an excellent prognosis in dogs. Despite similar outcomes of lower incidence of AKI in the TPE group, and slightly lower maximal creatinine concentration in dogs treated with ILE vs IVF alone, ILE and TPE should be considered in the management of severe NSAID toxicosis.