BodiMojo

BackgroundApproximately 70,000 adolescents and young adults (AYA) are diagnosed with cancer each year in the United States. Sarcomas carry a particularly high symptom burden and are some of the most common cancers among AYA. Recent work has documented significant levels of unmet needs among AYA with cancer, particularly the need for psychosocial support. Mobile technology may be a cost-effective and efficient way to deliver a psychosocial intervention to AYA with cancer and cancer survivors.ObjectiveThe two aims of this study were to (1) develop a pilot version of a mobile-based mindfulness and social support program and (2) evaluate program usage and acceptability. An exploratory aim was to examine change in psychosocial outcomes.MethodsThirty-seven AYA with sarcoma or sarcoma survivors, parents, and health care providers participated in the study. Semistructured interviews were conducted with 10 AYA, parents of five of the adolescents, and six health care providers. Themes from the interviews helped to inform the development of a mobile-based mindfulness pilot program and a companion Facebook-based social support group. Twenty AYA consented to participate in a single-arm pre-post evaluation of the program; 17 downloaded the app and joined the Facebook group. Seven of these participants had participated in the semistructured interviews. Six additional health care providers consented to participate in the evaluation stage.ResultsOn average, participants completed 16.9 of the 28 unique sessions and used the mindfulness app for a mean 10.2 (SD 8.2) days during the 28-day evaluation period. The majority of participants (16/17) engaged in the social group and posted at least one reply to the moderator’s prompts. The mean number of responses per person to the moderator of the social group was 15.2 of 31 (49%, range 0%-97%). Both AYA and health care providers responded positively to the Mindfulness for Resilience in Illness program and offered useful recommendations for improvements. Exploratory psychosocial analyses indicated there were no significant differences from pretest to posttest on measures of perceived social support, mindfulness, body image, or psychological functioning.ConclusionsThis study offers preliminary support for the feasibility and acceptability of a mobile-based mindfulness and Facebook-based social support program for AYA with sarcoma. The feedback from AYA and health care providers will assist in creating a fully developed intervention.Trial RegistrationClinicalTrials.gov NCT03130751; https://clinicaltrials.gov/ct2/show/NCT03130751

En el Centro Experimental Agropecuario Condoriri, Oruro, se evaluaron 82 accesiones de Solanum andigena, S. stenotonum y S. x juzepczukii con el objetivo de estudiar los mecanismos morfológicos asociados a la resistencia a heladas. Se evaluó el rendimiento y los factores morfológicos que contribuyen a la resistencia para heladas como la pigmentación del tallo, el tamaño de células estomáticas, el grosor de pared celular, el área estomática, el hábito de crecimiento de la planta, las capas de empalizada en el tejido parenquimatoso de las hojas y el porcentaje de tejido dañado. Los resultados mostraron que el número de estomas varia según el nivel de ploidía, observándose valores promedios de 60 estomas por campo óptico en S. x juzepczukii, 43 en S. stenotonum y 38 en S. andigena. El área estomática difiere entre especies, S. andigena mostró 515,3 μ2, S. stenotonum tuvo 418 μ2, S. x juzepczukii mostró 237 μ2. Hubo correlación entre la triple capa de empalizada en las células del parénquima y la resistencia a heladas en la especie S. x juzepczukii. En S. stenotonum se observó una doble empalizada en el parénquima, y tuvo menor porcentaje de daño en follaje. S andigena mostró una capa simple de empalizada y fue susceptible a las heladas. Las accesiones 147, 100, 108, 113, 142 y 96 de S. x juzepczukii, tienen tallos de pigmentación morada y hábito de crecimiento arrosetado y fueron las más resistentes a heladas. La accesión 100 de S. x juzepczukii tuvo el más alto rendimiento (9,8 t · ha-1) y la accesión 69 de S. andigena mostró el más bajo rendimiento (1,09 t · ha-1).