Brooklyn Navy Yard

Abstract In divided societies, can museums contribute to healing and recovery? While efforts to memorialize past violence typically aim to promote tolerance and reconciliation, remembering could exacerbate divisions in recovering societies where the past is deeply contested. We examine a transitional justice museum exhibit in Northern Ireland. We combine evidence from nearly 1,400 participants across focus groups, a field experiment at the Troubles and Beyond exhibit in the Ulster Museum, and a survey that randomly exposed respondents to exhibit materials. Our findings indicate that although individuals experience strong emotional responses to the exhibit materials, these emotions do not correspond to shifts in perceptions of past violent conflict or preferences for addressing it. These results may reflect the balanced curation of the museum exhibit, which avoids imposing a singular narrative. While this approach prevents further polarization, it also limits the potential for fostering social cohesion.

Cyber threats are evolving rapidly, making traditional malware detection approaches insufficient in handling sophisticated attacks such as zero-day exploits, polymorphic malware, and advanced persistent threats. As a solution to these problems, this study presents a novel hybrid AI-based data analysis framework for cyber threat intelligence and anomaly detection. We specifically proposed a model that combines autoencoders, random forests, and CNN-LSTM architectures to improve anomaly detection and classification. The dataset used for training and evaluation is the Microsoft Malware Dataset, a publicly available dataset. The AE-RF module learns the normal behavior of the system to detect abnormal behavior, and the CNN-LSTM model identifies spatial and temporal properties of malware for execution patterns. This article ensures that the dataset is well-preprocessed, including feature extraction, PCA, and SMOTE for class balancing to provide optimal model performance. The experimental results show that AE-RF has an area under curve (AUC) score of 0.91 and CNN-LSTM has 0.94, which demonstrates that unsupervised and supervised techniques together have high classification accuracy. This hybrid approach not only improves malware detection accuracy but also enhances cyber threat intelligence by providing interpretable insights into attack patterns. The study concludes that integrating multiple AI techniques can significantly improve cybersecurity defenses against evolving threats, paving the way for real-time, AI-powered malware detection solutions.

Purpose – The paper covers the subject of excess consumption. Referring to the role and effects of consumerism on the functioning of modern economies, societies, and in the life of every person/consumer. The considerations aim to answer the question: can money buy happiness? Research method – The method used in this study is analysis using secondary sources. Due to the research topic, the work is descriptive in nature and consists of an overview of theoretical aspects regarding happiness, values, consumerism, and the relationship between economic growth and happiness. Results – The results of the analysis indicate that consumerism, i.e. excess uncontrollable consumption, which is a manifestation of hedonism, leads to a crisis of personal values and economic crises. The problem of consumerism is one of the key problems of the modern world in many aspects and, through the degradation of the value system, it poses a huge threat to the future of mankind. Originality / value / implications / recommendations – Considerations of consumerism are of a philosophical and social nature with elements of economics. This approach to the topic is an added value in terms of economics. The study points to new directions of potentially interesting research. In the aspect of personal values, economic crises may lead to a re-evaluation of priorities and a new hierarchy of values that guide us in life. In search of the implications of crises for personal values, the article draws attention to the importance of economic crises.

Abstract Serrated colorectal cancer (CRC) is an aggressive and treatment-resistant form of colorectal carcinogenesis that accounts for one-fourth of the patients with CRC1. At the molecular level, serrated CRC is characterized by epigenetic modifications termed the CpG Island Methylator Phenotype (CIMP) and the presence of somatic mutations that activate the mitogen-activated protein kinase (MAPK) pathway1,2,3. The BRAFV600E is an early genetic change in serrated polyps, but it is not sufficient to drive tumor formation. Combinations of mutations and epigenetic modifications in P16INK4A, MLH1, ZNFR3, RNF43, and TGFBR2 are often seen in most patients4. Therefore, a combinatorial approach to develop BrafV600E-driven serrated CRC organoids harboring a variety of the above mutants will enable in vitro studies of the tumorigenic potential of each combination as well as allow engraftment into animals. In turn, the latter will allow for applying preclinical in-vivo pharmacology modalities in vitro, thereby bypassing the time required to create a specific knock-in/out strain for each genetic modification desired. Here, we describe a pipeline to directly genetically manipulate specific organoid systems in vitro. We first established organoid cultures from the small and large intestine of unique Tet-inducible RNAi mice where efficient gene knock-down can contribute to microsatellite instability. Using CRISPR/Cas9, we then edited these to generate CRC organoid models containing the BrafV600E mutation in combination with knock outs or knock-ins of cell cycle regulators and negative regulators of the Wnt pathway. These deficiencies mimic the progressive mutational changes upon acquisition BrafV600E. Our data lay the groundwork for future use of RNAi technology in combination with sequential gene editing for in vitro pharmacology and modeling diseases with complex genetic architecture both in vitro and in vivo. Citation Format: Prem K. Premsrirut, Huaien Wang, Eduardo J. Garcia Reino, Isabella Breen, Ana A. Vasileva. Utility of intestinal organoids to model serrated colon cancer in vitro [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 946.

A biocomposite material was developed consisting of microcapsules of a polyurethane/polyurea copolymer with hydrocarbon-oxidizing bacteria immobilized on them. The use of new material increases the efficiency of the destruction of hydrocarbons.

There are many factors affecting and determining food selection in Beni Suef Governorate, through the field study of the study sample that took place in November 2016 with the distribution of about 460 questionnaire forms showing that family size and family income are among the most important factors affecting food consumption, as there is a direct relationship between the number of family members, their income and the degree of food consumption.They have awareness of the types and quantities of food they consume, as the greater the number of family members, the greater the demand for food, especially legumes and vegetables, and the less consumption of high-priced commodities such as meat and fruits.Although income is the primary determinant of food purchase, these data only appeared in specific commodities.Like meat and its quality Proximity or distance from markets and cooperative and consumer societies is one of the incentives to purchase food commodities due to the relatively low prices.It has been found that the spatial distribution of markets and cooperative societies is unfair within the city of Beni Suef, which requires providing alternative sources for these complexes in the form of kiosks that are distributed in a fair and appropriate manner.There is no objection to geographic information systems having a role in their distribution, taking into account the distribution of the population in each neighborhood of the cityThe increase in prices during the period (2009-2017), which was linked to the liberalization of the exchange rate of the pound, had a clear impact on the purchasing power of low-income groups, and this was evident through the purchase of food commodities with a lower monetary and food value, as these increases came in the prices of necessary food commodities such as meat and others, And they came close and did not match the increase in income in the study area, which necessarily means that we are facing a problem of malnutrition for many low-income families By analyzing and tracking the numbers of the food gap study, it was found that the governorate suffers from a food gap for some strategic commodities such as wheat, rice and red meat despite the continuous increase in the area of the wheat crop, but it is not commensurate with the population increase.The self-sufficiency rates of these crops were as follows: 25.18% for wheat, 5.35% for rice, 162.12% for red meat in 2009 and it was 74.96% for wheat, 4.23% for rice, and 61.96% for red meat in 2017.

Background: Prior to this project, patients were required to drive up to 2 hours to a diabetes education centre. As a result, many patients were not receiving diabetes education, and there was little or no follow-up of patients. Significant opportunity exists for pharmacists to fill such gaps in chronic disease management services. Methods: Patients were randomly assigned to the intervention or usual care arm. Laboratory data (glycosylated hemoglobin, fasting blood glucose, lipid panel, microalbumin, systolic and diastolic blood pressure) and Diabetes Empowerment Scale short form (DES-SF) score were collected at baseline and at 6 months. Intervention patients received a medication review, 3 one-on-one education sessions with one of the study pharmacists and follow-up phone calls. Usual care patients did not receive medication reviews or education sessions, and received follow-up phone calls only if drug-related problems were detected. Drug-related problems were tracked for all patients. Referrals to other health care professionals (dietitian, homecare, public health) were made as required. Paired-sample t-tests were used to compare baseline and 6-month data. Results: Forty-five patients were enrolled in the study (intervention: 23; usual care: 17). Five patients were lost to follow-up (intervention: 2; usual care: 3). There was a statistically significant improvement in DES-SF score in the intervention group ( p < 0.001) and a decline in DES-SF score in the usual care group ( p < 0.04). There was a significant decrease in glycosylated hemoglobin in the usual care group ( p < 0.04). Referrals to other health care professionals were higher in the intervention group (I: 36; UC: 0). The number of drug-related problems detected was also greater in the intervention group (I: 83; UC: 8). The overall acceptance rate of pharmacist recommendations for drug-related problems was high in both arms (I: 81%; UC: 100%). Conclusions: Most outcome measures were not statistically significant. Further study is needed to evaluate the change in clinical outcomes. However, greater involvement of a pharmacist in diabetes management resulted in greater detection of drug-related problems and referral to other health care professionals, and promoted diabetes-related self-efficacy and appropriate self-care behaviour. Pharmacists can play an important role in the management of diabetic patients.