Bunge & Born Foundation

We aim to delineate the clinicopathological phenotype of rare ABCA7 mutation carriers in Belgian cerebral amyloid angiopathy (CAA) patients.

Abstract Calculating the consequences of global public bads such as climate change or pandemics helps uncover the scale, distribution and structure of their economic burdens. As violent conflict affects billions of people worldwide, whether directly or indirectly, this article sets out to estimate its global macro-economic repercussions. Using a novel methodology that accounts for multiple dimensions of war, the article finds that, in the absence of violent conflict since 1970, the level of global GDP in 2014 would have been, on average, 12% higher. When disaggregating these results by conflict type, civil conflicts are estimated to have been the costliest by far. Income growth is found to be altered up to four years following the end of a conflict, although the direction of this relationship depends on the intensity and type of conflict. Countries also suffer significantly from fighting in neighbouring countries, thereby showing the importance of mitigating spillovers rapidly. The largest absolute losses associated with violence emanate from Asia, while many high-income economies are found to benefit economically from participating in conflicts on foreign soil. This analysis thus shows that, despite some evidence of a faster post-conflict growth and possible benefits for external participants, violent conflict leads to net global losses that linger long after peace is achieved, reducing the peace dividend. The article concludes by discussing public policy options to strengthen the benefits of peace as a global public good.

The primary breast tumors of 27 patients were analyzed for the expression of estrogen receptors (ER) and DNA synthesis. Seventeen tumors were ER-positive, and the simultaneous expression of ER and DNA synthesis could be analyzed in 14 ER-positive tumors. DNA synthesis was measured through the thymidine labeling index (TLI). ER expression was detected by immunohistochemistry with monoclonal antibodies. In these tumors, 38.6% +/- 13.1% of the cells were ER-positive (average TLI = 0.60% +/- 0.70%), as opposed to the presence of 61.4% +/- 13.1% of ER-negative cells (average TLI = 0.65% +/- 0.53%). In 12 of 14 tumors, both ER-positive and ER-negative cells were found to be engaged in DNA synthesis, whereas in two tumors only ER-negative cells were synthesizing DNA. On the basis of the TLI and the proportion of ER-negative and ER-positive cells in the total population, it is suggested that the ER-positive and ER-negative compartments are interrelated in most tumors. In five tumors, the ER-negative compartment would be a precursor of the ER-positive segment, whereas in six tumors the ER-positive segment appears to be a precursor of the ER-negative one. In three tumors, no evidence of an interrelationship between both segments could be found. In the 14 tumors analyzed, it also was found that 69.1% +/- 21.3% of the DNA-synthesizing cells were ER-negative; this probably accounts for the temporary remissions observed after hormonal treatment in breast cancer.

The existence of cross-idiotypic determinants among human oligoclonal Subacute Sclerosing Panencephalitis (SSPE) immunoglobulins was shown by the use of monospecific rabbit anti-idiotypic antisera. Sharing of idiotypy was also shown to exist to a lesser extent with sera from patients with Multiple Sclerosis (MS), another disease of the central nervous system. No reaction was observed with sera from other neurological diseases. Appropriate controls excluded artefacts due to a prevalent subclass of immunoglobulins in SSPE or MS. Identity with SSPE cerebrospinal fluid immunoglobulins and SSPE serum proteins was also demonstrated by the anti-idiotypic antibodies.