Bunker Hill Community College

Current antigen delivery platforms, such as alum and nanoparticles, are not readily tunable, thus may not generate optimal adaptive immune responses. We created an antigen delivery platform by loading lyophilized Microporous Annealed Particle (MAP) with aqueous solution containing target antigens. Upon administration of antigen loaded MAP (VaxMAP), the biomaterial reconstitution forms an instant antigen-loaded porous scaffold area with a sustained release profile to maximize humoral immunity. VaxMAP induced CD4+ T follicular helper (Tfh) cells and germinal center (GC) B cell responses in the lymph nodes similar to Alum. VaxMAP loaded with SARS-CoV-2 spike protein improved the magnitude and duration of anti-receptor binding domain antibodies compared to Alum and mRNA-vaccinated mice. A single injection of Influenza specific HA1-loaded-VaxMAP enhanced neutralizing antibodies and elicited greater protection against influenza virus challenge than HA1-loaded-Alum. Thus, VaxMAP is a platform that can be used to promote adaptive immune cell responses to generate more robust neutralizing antibodies, and better protection upon pathogen challenge.

Abstract Despite attending schools in a state internationally recognized for innovation, research and education, Latine students in Massachusetts, USA continue to disproportionately experience discrimination, economic segregation, health disparities and racial inequities that have shaped their schooling experiences and outcomes across the educational pipeline (Colón, “We are beautiful people”: The schooling experiences of Puerto Rican school‐aged mothers [PhD Thesis]. Tufts University, 2019). Grounded in critical analysis of intercultural education towards social justice (Pica‐Smith et al., Social justice education in European multi‐ethnic schools. Addressing the goals of intercultural education. Routledge Taylor & Francis Group, London, 2019), this paper critically examines publicly available data to highlight barriers, opportunities and the need for educational researchers, policymakers and administrators to collectively reimagine an educational project that attends to the needs of this population. In the context of the unyielding disparate impact of COVID‐19, we argue that more ever, this reimagination needs to be grounded in the dynamic conception of culture (Levitt et al., International Migration Review, 38, 1002, 2004), intercultural perspectives on education that are based on critical notions of intergroup contact, dialogue and exchange (Allport, Forms and techniques of altruistic and spiritual growth: a symposium, 1954, 367; Council of Europe, White paper on intercultural dialogue. Living together as equals in dignity, Strasburgo, 2008) and multidimensional notion of belonging at the micro and macro levels for a more just education writ large.

In this paper, we synthesize the current literature on group-based social skills interventions (GSSIs) for adolescents (ages 10–20 years) with higher-functioning autism spectrum disorder and identify key concepts that should be addressed in future research on GSSIs. We consider the research participants, the intervention, the assessment of the intervention, and the research methodology and results to be integral and interconnected components of the GSSI literature, and we review each of these components respectively. Participant characteristics (eg, age, IQ, sex) and intervention characteristics (eg, targeted social skills, teaching strategies, duration and intensity) vary considerably across GSSIs; future research should evaluate whether participant and intervention characteristics mediate/moderate intervention efficacy. Multiple assessments (eg, parent-report, child-report, social cognitive assessments) are used to evaluate the efficacy of GSSIs; future research should be aware of the limitations of current measurement approaches and employ more accurate, sensitive, and comprehensive measurement approaches. Results of GSSIs are largely inconclusive, with few consistent findings across studies (eg, high parent and child satisfaction with the intervention); future research should employ more rigorous methodological standards for evaluating efficacy. A better understanding of these components in the current GSSI literature and a more sophisticated and rigorous analysis of these components in future research will lend clarity to key questions regarding the efficacy of GSSIs for individuals with autism spectrum disorder.

The baby boomer generation did not get to win a war, but it got the Green Bay Packers. This is not an altogether flippant remark. While the 1960s brought “new frontiers” from psychedelics to draft dodging, the decade also ushered in a new frontier in sports. The National Football League (NFL) went from a gritty, noirish black-and-white Sunday sideshow where fullbacks slogged in mud and kickers got lost in snowstorms to the preeminent American televised sport. In a decade that saw a political spectrum from the Kennedy brothers to George Wallace, black leaders as opposite as Martin Luther King Jr. and Huey Newton, musicians as divergent as Neil Sedaka and Jimi Hendrix, movements from civil rights to revolution, women's liberation, gay liberation, and Students for a Democratic Society, LSD, and events from the Summer of Love to the My Lai massacre—when the country sometimes seemed to be falling...