CatScI (United Kingdom)

ADVERTISEMENT RETURN TO ISSUEHighlights from the ...Highlights from the LiteratureNEXTSome Items of Interest to Process R&D Chemists and EngineersAlan StevenAlan StevenCatSci Ltd, CBTC2, Capital Business Park, Wentloog, Cardiff CF3 2PX, U.K.More by Alan Stevenhttps://orcid.org/0000-0002-0134-0918, Carlos MateosCarlos MateosDiscovery Chemistry Research and Technologies, Eli Lilly and Co., Avenida de la Industria 30, 28108 Alcobendas, SpainMore by Carlos Mateoshttps://orcid.org/0000-0002-0189-4136, Andrei A. ZlotaAndrei A. ZlotaThe Zlota Company, 97 Brooksmont Drive, Holliston, Massachusetts 01746-1770, United StatesMore by Andrei A. Zlotahttps://orcid.org/0000-0002-2048-9187, Alexandre BarthelmeAlexandre BarthelmeCenter of Expertise Drug Substance, UCB Pharma, Chemin du Foriest 1, 1420 Braine-l'Alleud, BelgiumMore by Alexandre Barthelme, Paul F. RichardsonPaul F. RichardsonPfizer, Chemistry, 10578 Science Center Drive, San Diego, California 09121, United StatesMore by Paul F. Richardsonhttps://orcid.org/0000-0002-3700-8749, Robert B. KargboRobert B. KargboUsona Institute, 2881 Woods Hollow Road, Fitchburg, Wisconsin 53711, United StatesMore by Robert B. Kargbohttps://orcid.org/0000-0002-5539-6343, Thomas VerheyenThomas VerheyenAPI Small Molecule Process R&D, Janssen Pharmaceutical Companies of Johnson & Johnson Turnhoutseweg 30, 2340 Beerse, BelgiumMore by Thomas Verheyenhttps://orcid.org/0000-0003-0831-3901, and John Knight*John KnightJKonsult Ltd, Meadow View, Cross Keys, Hereford HR1 3NT, U.K.*Email: [email protected]More by John KnightCite this: Org. Process Res. Dev. 2024, 28, 3, 641–651Publication Date (Web):March 5, 2024Publication History Received20 February 2024Published online5 March 2024Published inissue 15 March 2024https://doi.org/10.1021/acs.oprd.4c00066Copyright © Published 2024 by American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views3809Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (2 MB) Get e-AlertscloseSUBJECTS:Catalysts,Hydrocarbons,Ligands,Peptides and proteins,Selectivity Get e-Alerts

ADVERTISEMENT RETURN TO ISSUEPREVHighlights from the ...Highlights from the LiteratureNEXTSome Items of Interest to Process R&D Chemists and EngineersAlan StevenAlan StevenCatSci Ltd, CBTC2, Capital Business Park, Wentloog, Cardiff CF3 2PX, U.K.More by Alan Stevenhttps://orcid.org/0000-0002-0134-0918, Carlos MateosCarlos MateosDiscovery Chemistry Research and Technologies, Eli Lilly and Co., Avenida de la Industria 30, 28108 Alcobendas, SpainMore by Carlos Mateoshttps://orcid.org/0000-0002-0189-4136, Andrei A. ZlotaAndrei A. ZlotaThe Zlota Company, LLC, 97 Brooksmont Drive, Holliston, Massachusetts 01746-1770, United StatesMore by Andrei A. Zlotahttps://orcid.org/0000-0002-2048-9187, Christopher C. NawratChristopher C. NawratMerck & Co. Inc., Rahway, New Jersey 07065, United StatesMore by Christopher C. Nawrathttps://orcid.org/0000-0003-4550-9954, Alexandre BarthelmeAlexandre BarthelmeCenter of Expertise Drug Substance, UCB Pharma, Chemin du Foriest 1, 1420 Braine-l'Alleud, BelgiumMore by Alexandre Barthelme, Rik OostRik OostAPI Small Molecule Process R&D, Janssen Pharmaceutical Companies of Johnson & Johnson, Turnhoutseweg 30, 2340 Beerse, BelgiumMore by Rik Oost, Paul F. RichardsonPaul F. RichardsonPfizer, Chemistry, 10578 Science Center Drive, San Diego, California 09121, United StatesMore by Paul F. Richardsonhttps://orcid.org/0000-0002-3700-8749, Robert B. KargboRobert B. KargboUsona Institute, 277 Granada Drive, San Luis Obispo, California 93401, United StatesMore by Robert B. Kargbohttps://orcid.org/0000-0002-5539-6343, and John Knight*John KnightJKonsult Ltd, Meadow View, Cross Keys, Hereford HR1 3NT, U.K.*Email: [email protected]More by John KnightCite this: Org. Process Res. Dev. 2023, 27, 7, 1210–1219Publication Date (Web):July 12, 2023Publication History Received27 June 2023Published online12 July 2023Published inissue 21 July 2023https://pubs.acs.org/doi/10.1021/acs.oprd.3c00206https://doi.org/10.1021/acs.oprd.3c00206editorialACS PublicationsCopyright © Published 2023 by American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views4581Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (3 MB) Get e-AlertscloseSUBJECTS:Alcohols,Catalysts,Chemical reactions,Organic synthesis,Pyridines Get e-Alerts

Abstract Photoredox catalysis has advanced significantly over the last fifteen years, with improvements in technology facilitating implementation in both academic and industrial settings. Despite these advances, the uptake of photoredox catalysis in pharmaceutical development and manufacture has been slow, in part due to the challenge of developing a robust, transferable process. This perspective provides insight on the successes and difficulties encountered when applying photoredox catalysis to pharmaceutical development. It is hoped greater understanding of the challenges faced by the pharmaceutical industry will inform future research and encourage collaboration.

ADVERTISEMENT RETURN TO ISSUEHighlights from the ...Highlights from the LiteratureNEXTSome Items of Interest to Process R&D Chemists and EngineersPaul F. RichardsonPaul F. RichardsonPfizer, Chemistry, 10578 Science Center Drive, San Diego, California 09121, United StatesMore by Paul F. Richardsonhttps://orcid.org/0000-0002-3700-8749, Alan StevenAlan StevenCatSci Ltd, CBTC2, Capital Business Park, Wentloog, Cardiff CF3 2PX, U.K.More by Alan Stevenhttps://orcid.org/0000-0002-0134-0918, Robert B. KargboRobert B. KargboUsona Institute, 277 Granada Drive, San Luis Obispo, California 93401, United StatesMore by Robert B. Kargbohttps://orcid.org/0000-0002-5539-6343, Carlos MateosCarlos MateosDiscovery Chemistry Research and Technologies, Eli Lilly and Co., Avenida de la Industria 30, 28108 Alcobendas, SpainMore by Carlos Mateoshttps://orcid.org/0000-0002-0189-4136, Andrei A. ZlotaAndrei A. ZlotaThe Zlota Company, LLC, 97 Brooksmont Drive, Holliston, Massachusetts 01746-1770, United StatesMore by Andrei A. Zlotahttps://orcid.org/0000-0002-2048-9187, Christopher C. NawratChristopher C. NawratMerck & Co. Inc., Rahway, New Jersey 07065, United StatesMore by Christopher C. Nawrathttps://orcid.org/0000-0003-4550-9954, Rik OostRik OostAPI Small Molecule Process R&D, Janssen Pharmaceutical Companies of Johnson & Johnson, Turnhoutseweg 30, 2340 Beerse, BelgiumMore by Rik Oost, James P. PhelanJames P. PhelanMedicinal Chemistry, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United StatesMore by James P. Phelanhttps://orcid.org/0000-0002-0058-0653, Alexandre BarthelmeAlexandre BarthelmeCenter of Expertise Drug Substance, UCB Pharma, Chemin Du Foriest 1, 1420 Braine-l'Alleud, BelgiumMore by Alexandre Barthelme, Sylvain GuizzettiSylvain GuizzettiNovAlix, Building A: Chemistry, Bioparc, Bld. Sébastien Brant, BP 30170, F-67405 Illkirch Cedex, FranceMore by Sylvain Guizzettihttps://orcid.org/0000-0003-4656-2431, and John Knight*John KnightJKonsult Ltd, Meadow View, Cross Keys, Hereford HR1 3NT, U.K.*Email: [email protected]More by John KnightCite this: Org. Process Res. Dev. 2022, 26, 11, 2997–3009Publication Date (Web):November 9, 2022Publication History Received24 October 2022Published online9 November 2022Published inissue 18 November 2022https://pubs.acs.org/doi/10.1021/acs.oprd.2c00334https://doi.org/10.1021/acs.oprd.2c00334editorialACS PublicationsCopyright © Published 2022 by American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views5724Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (3 MB) Get e-AlertscloseSUBJECTS:Catalysts,Functionalization,Hydrocarbons,Pharmaceuticals,Reaction products Get e-Alerts

ADVERTISEMENT RETURN TO ISSUEHighlights from the ...Highlights from the LiteratureNEXTSome Items of Interest to Process R&D Chemists and EngineersPaul F. RichardsonPaul F. RichardsonPfizer, Chemistry, 10578 Science Center Drive, San Diego, California 09121, United StatesMore by Paul F. Richardsonhttps://orcid.org/0000-0002-3700-8749, Alan StevenAlan StevenCatSci Ltd, CBTC2, Capital Business Park, Wentloog, Cardiff CF3 2PX, U.K.More by Alan Stevenhttps://orcid.org/0000-0002-0134-0918, Robert B. KargboRobert B. KargboUsona Institute, 277 Granada Drive, San Luis Obispo, California 93401, United StatesMore by Robert B. Kargbohttps://orcid.org/0000-0002-5539-6343, Carlos MateosCarlos MateosDiscovery Chemistry Research and Technologies, Eli Lilly and Company, Avenida de la Industria 30, 28108 Alcobendas, SpainMore by Carlos Mateoshttps://orcid.org/0000-0002-0189-4136, Andrei A. ZlotaAndrei A. ZlotaThe Zlota Company, LLC, 97 Brooksmont Drive, Holliston, Massachusetts 01746-1770, United StatesMore by Andrei A. Zlotahttps://orcid.org/0000-0002-2048-9187, Christopher C. NawratChristopher C. NawratMerck & Co. Inc., Rahway, New Jersey 07065, United StatesMore by Christopher C. Nawrathttps://orcid.org/0000-0003-4550-9954, Antonio RamirezAntonio RamirezChemical Development, Bristol-Myers Squibb, One Squibb Drive, New Brunswick, New Jersey 08903, United StatesMore by Antonio Ramirezhttps://orcid.org/0000-0003-2636-6855, and John Knight*John KnightJKonsult Ltd, Meadow View, Cross Keys, Hereford HR1 3NT, U.K.*Email: [email protected]More by John KnightCite this: Org. Process Res. Dev. 2022, 26, 1, 1–9Publication Date (Web):January 5, 2022Publication History Published online5 January 2022Published inissue 21 January 2022https://pubs.acs.org/doi/10.1021/acs.oprd.1c00482https://doi.org/10.1021/acs.oprd.1c00482editorialACS PublicationsCopyright © Published 2022 by American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views5584Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (2 MB) Get e-AlertscloseSUBJECTS:Chemical reactions,Crystallization,Hydrocarbons,Reactivity,Solvents Get e-Alerts

ADVERTISEMENT RETURN TO ISSUEHighlights from the ...Highlights from the LiteratureNEXTSome Items of Interest to Process R&D Chemists and EngineersKiran MatchaKiran MatchaAPI Small Molecule Process R&D, Janssen Pharmaceutical Companies of Johnson & Johnson, Turnhoutseweg 30, 2340 Beerse, BelgiumMore by Kiran Matcha, Paul RichardsonPaul RichardsonPfizer, Chemistry, 10578 Science Center Drive, San Diego, California 09121, United StatesMore by Paul Richardson, Alan StevenAlan StevenCatSci Ltd, CBTC2, Capital Business Park, Wentloog, Cardiff CF3 2PX, U.K.More by Alan Stevenhttp://orcid.org/0000-0002-0134-0918, Robert KargboRobert KargboUsona Institute, 277 Granada Drive, San Luis Obispo, California 93401, United StatesMore by Robert Kargbohttp://orcid.org/0000-0002-5539-6343, Christopher C. NawratChristopher C. NawratMerck & Co. Inc., Rahway, New Jersey 07065, United StatesMore by Christopher C. Nawrathttp://orcid.org/0000-0003-4550-9954, Carlos MateosCarlos MateosDiscovery Chemistry Research and Technologies, Eli Lilly and Co., Avenida de la Industria 30, 28108 Alcobendas, SpainMore by Carlos Mateoshttp://orcid.org/0000-0002-0189-4136, Andrei A. ZlotaAndrei A. ZlotaThe Zlota Company, LLC, 15 Fairbanks Road, Sharon, Massachusetts 02067-2858, United StatesMore by Andrei A. Zlota, and John Knight*John KnightJKonsult Ltd, Meadow View, Cross Keys, Hereford HR1 3NT, U.K.*Email: [email protected]More by John KnightCite this: Org. Process Res. Dev. 2020, 24, 11, 2383–2393Publication Date (Web):November 11, 2020Publication History Published online11 November 2020Published inissue 20 November 2020https://pubs.acs.org/doi/10.1021/acs.oprd.0c00481https://doi.org/10.1021/acs.oprd.0c00481article-commentaryACS PublicationsCopyright © 2020 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views4337Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (2 MB) Get e-AlertscloseSUBJECTS:Alkyls,Anions,Catalysts,Cross coupling reaction,Solvents Get e-Alerts

ADVERTISEMENT RETURN TO ISSUEHighlights from the ...Highlights from the LiteratureNEXTSome Items of Interest to Process R&D Chemists and EngineersPaul RichardsonPaul RichardsonPfizer, Chemistry, 10578 Science Center Drive, San Diego, California 09121, United StatesMore by Paul Richardson, Alan StevenAlan StevenCatSci Ltd, CBTC2, Capital Business Park, Wentloog, Cardiff CF3 2PX, U.K.More by Alan Stevenhttp://orcid.org/0000-0002-0134-0918, Robert KargboRobert KargboUsona Institute, 277 Granada Drive, San Luis Obispo, California 93401, United StatesMore by Robert Kargbohttp://orcid.org/0000-0002-5539-6343, Christopher C. NawratChristopher C. NawratMerck & Co. Inc., Rahway, New Jersey 07065, United StatesMore by Christopher C. Nawrathttp://orcid.org/0000-0003-4550-9954, Carlos MateosCarlos MateosDiscovery Chemistry Research and Technologies, Eli Lilly and Co., Avenida de la Industria 30, 28108 Alcobendas, SpainMore by Carlos Mateoshttp://orcid.org/0000-0002-0189-4136, Andrei A. ZlotaAndrei A. ZlotaThe Zlota Company, LLC, 15 Fairbanks Road, Sharon, Massachusetts 02067-2858, United StatesMore by Andrei A. Zlota, and John Knight*John KnightJKonsult Ltd, Meadow View, Cross Keys, Hereford HR1 3NT, U.K.*Email: [email protected]More by John KnightCite this: Org. Process Res. Dev. 2020, 24, 9, 1549–1557Publication Date (Web):September 10, 2020Publication History Published online10 September 2020Published inissue 18 September 2020https://pubs.acs.org/doi/10.1021/acs.oprd.0c00381https://doi.org/10.1021/acs.oprd.0c00381article-commentaryACS PublicationsCopyright © 2020 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views3775Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (2 MB) Get e-AlertscloseSUBJECTS:Cations,Coupling reactions,Functional groups,Pharmaceuticals,Salts Get e-Alerts

ADVERTISEMENT RETURN TO ISSUEPREVHighlights from the ...Highlights from the LiteratureNEXTSome Items of Interest to Process R&D Chemists and EngineersPaul RichardsonPaul RichardsonPfizer, Chemistry, 10578 Science Center Drive, San Diego, California 09121, United StatesMore by Paul Richardson, Alan StevenAlan StevenCatSci Ltd, CBTC2, Capital Business Park, Wentloog, Cardiff CF3 2PX, U.K.More by Alan Stevenhttp://orcid.org/0000-0002-0134-0918, Robert KargboRobert KargboUsona Institute, 277 Granada Drive, San Luis Obispo, California 93401, United StatesMore by Robert Kargbohttp://orcid.org/0000-0002-5539-6343, Christopher C. NawratChristopher C. NawratMerck & Co. Inc., Rahway, New Jersey 07065, United StatesMore by Christopher C. Nawrathttp://orcid.org/0000-0003-4550-9954, Carlos MateosCarlos MateosDiscovery Chemistry Research and Technologies, Eli Lilly and Co., Avenida de la Industria 30, 28108 Alcobendas, SpainMore by Carlos Mateoshttp://orcid.org/0000-0002-0189-4136, Andrei A. ZlotaAndrei A. ZlotaThe Zlota Company, LLC, 15 Fairbanks Road, Sharon, Massachusetts 02067-2858, United StatesMore by Andrei A. Zlota, Kiran MatchaKiran MatchaAPI Small Molecule Process R&D, Janssen Pharmaceutical Companies of Johnson & Johnson Turnhoutseweg 30, 2340 Beerse, BelgiumMore by Kiran Matcha, and John Knight*John KnightJKonsult Ltd, Meadow View, Cross Keys, Hereford HR1 3NT, U.K.*Email: [email protected]More by John KnightCite this: Org. Process Res. Dev. 2020, 24, 7, 1218–1227Publication Date (Web):July 8, 2020Publication History Published online8 July 2020Published inissue 17 July 2020https://pubs.acs.org/doi/10.1021/acs.oprd.0c00290https://doi.org/10.1021/acs.oprd.0c00290article-commentaryACS PublicationsCopyright © 2020 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views4389Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (2 MB) Get e-AlertscloseSUBJECTS:Amines,Anions,Chemical reactions,Crystallization,Solvents Get e-Alerts

A range of generic active pharmaceutical ingredients were examined for potential chiral alcohol motifs and derivatives within their structures that could be employed as key synthetic intermediates. For seven generic active pharmaceutical ingredients (APIs), eight precursor ketones were acquired and then subjected to reduction by >400 commercially available ketone reductases from different suppliers. Positive screening results were achieved for five ketones screened, with multiple ketone reductases available for each successful ketone. Selectivity was typically >99.5% ee in most cases, including for the opposite enantiomer. The three best examples were then optimized and quickly scaled up to 1 L scale in high conversion and isolated yield while retaining selectivity of >99.5% ee for the desired chiral alcohol enantiomer. This work illustrates that where a wide range of enzymes are available, productive enzymes to give either alcohol enantiomer can be readily identified for many ketones and rapidly scaled up to produce chiral alcohols. This approach is particularly applicable to generating chiral API intermediates.

Abstract Transition metal‐catalysed reactions are often strongly dependent on ligand and selection, among other factors, which makes discovering the ideal metal/ligand/solvent combination demanding. Furthermore, the effect of ligand and solvent choice is often subtle and unpredictable. This perspective describes how two statistical techniques, design of experiments (DoE) and principal component analysis (PCA), can be combined to guide the decision‐making process. The general approach to using these techniques is described, and illustrated with a brief worked example on challenging ‘borrowing hydrogen’ chemistry. The unique combination of DoE and PCA is a useful decision‐making tool to support the selection of ligands and solvents for challenging catalytic reactions. © 2014 Society of Chemical Industry