Central New York Research Corporation

When patients who undergo ostomy surgery do not have access to an ostomy care nurse, staff nurses must assume responsibility for providing ostomy care and educational support. However, many staff nurses may lack the necessary knowledge and skills to provide this type of care. This article details the basics of pre- and postoperative care and patient education for nurses who encounter patients with two of the most common types of ostomy surgery of the bowel: colostomy and ileostomy. It covers the care of a new stoma and provides information about emptying and changing the pouch, nutritional and lifestyle considerations, and possible complications.

Purpose: To report successful in vivo fertilization in four out of five women with diminished ovarian reserve (DOR) after transuterine perfusion of the ovaries and pelvis with autologous platelet-rich plasma (PRP). Methods: Patients that exhibited DOR (defined as AMH <1.1 ng/mL and antral follicular count of < 7 follicles) and had failed in vitro fertilization and/or artificial insemination in the past year were offered transuterine perfusion of PRP with oral letrozole and timed intercourse as an alternative therapy. Five patients accepted the protocol. Patients took 10 mg of letrozole orally from day 3 to day 7 of the menstrual cycle to increase chances of ovulation. They underwent one transuterine perfusion of the pelvis during the follicular phase of each cycle with a 10 mL volume of fresh autologous platelet-rich plasma under ultrasound guidance to allow periovarian spillage from the fallopian tubes. Result: In 4 out of 5 cases patients conceived without the need for in vitro intervention. Three patients had a successful pregnancy. One patient had a miscarriage at 19 weeks. One patient did not conceive within the four months of observation. Conclusion: Delivering platelet-rich plasma to the ovaries by transuterine perfusion may be a safe and cost-effective approach to enhance fertility in women with impaired ovarian reserve undergoing fertility therapies.

SQ109 is a tuberculosis drug candidate that has high potency against Mycobacterium tuberculosis and is thought to function at least in part by blocking cell wall biosynthesis by inhibiting the MmpL3 transporter. It also has activity against bacteria and protozoan parasites that lack MmpL3, where it can act as an uncoupler, targeting lipid membranes and Ca2+ homeostasis. Here, we synthesized 18 analogs of SQ109 and tested them against M. smegmatis, M. tuberculosis, M. abscessus, Bacillus subtilis, and Escherichia coli, as well as against the protozoan parasites Trypanosoma brucei, T. cruzi, Leishmania donovani, L. mexicana, and Plasmodium falciparum. Activity against the mycobacteria was generally less than with SQ109 and was reduced by increasing the size of the alkyl adduct, but two analogs were ∼4-8-fold more active than SQ109 against M. abscessus, including a highly drug-resistant strain harboring an A309P mutation in MmpL3. There was also better activity than found with SQ109 with other bacteria and protozoa. Of particular interest, we found that the adamantyl C-2 ethyl, butyl, phenyl, and benzyl analogs had 4-10× increased activity against P. falciparum asexual blood stages, together with low toxicity to a human HepG2 cell line, making them of interest as new antimalarial drug leads. We also used surface plasmon resonance to investigate the binding of inhibitors to MmpL3 and differential scanning calorimetry to investigate binding to lipid membranes. There was no correlation between MmpL3 binding and M. tuberculosis or M. smegmatis cell activity, suggesting that MmpL3 is not a major target in mycobacteria. However, some of the more active species decreased lipid phase transition temperatures, indicating increased accumulation in membranes, which is expected to lead to enhanced uncoupler activity.

Although many individuals who experience a trauma go on to develop post-traumatic stress disorder (PTSD), the rate of PTSD following trauma is only about 15–24%. There must be some pre-existing conditions that impart increased vulnerability to some individuals and not others. Diathesis models of PTSD theorize that pre-existing vulnerabilities interact with traumatic experiences to produce psychopathology. Recent work has indicated that personality factors such as behavioral inhibition (BI), harm avoidance (HA), and distressed (Type D) personality are vulnerability factors for the development of PTSD and anxiety disorders. These personality temperaments produce enhanced acquisition or maintenance of associations, especially avoidance, which is a criterion symptom of PTSD. In this review, we highlight the evidence for a relationship between these personality types and enhanced avoidance and associative learning, which may increase risk for the development of PTSD. First, we provide the evidence confirming a relationship among BI, HA, distressed (Type D) personality, and PTSD. Second, we present recent findings that BI is associated with enhanced avoidance learning in both humans and animal models. Third, we will review evidence that BI is also associated with enhanced eyeblink conditioning in both humans and animal models. Overall, data from both humans and animals suggest that these personality traits promote enhanced avoidance and associative learning, as well as slowing of extinction in some training protocols, which all support the learning diathesis model. These findings of enhanced learning in vulnerable individuals can be used to develop objective behavioral measures to pre-identify individuals who are more at risk for development of PTSD following traumatic events, allowing for early (possibly preventative) intervention, as well as suggesting possible therapies for PTSD targeted on remediating avoidance or associative learning. Future work should explore the neural substrates of enhanced avoidance and associative learning for behaviorally inhibited individuals in both the animal model and human participants.

Clostridium difficile is a Gram-positive bacterium commonly found in health care and long-term-care facilities and is the most common cause of antibiotic-associated diarrhea. Rapid detection of this bacterium can assist physicians in implementing contact precautions and appropriate antibiotic therapy in a timely manner. The purpose of this study was to compare the clinical performance of the Quidel Lyra Direct C. difficile assay (Lyra assay) (Quidel, San Diego, CA) to that of a direct cell culture cytotoxicity neutralization assay (CCNA) and enhanced toxigenic culture. This study was performed at three geographically diverse laboratories within the United States using residual stool specimens submitted for routine C. difficile testing. Residual samples were tested using the Lyra assay on three real-time PCR platforms, and results were compared to those for direct CCNA and enhanced toxigenic culture. The test results for all platforms were consistent across all three test sites. The sensitivity and specificity of the Lyra assay on the SmartCycler II, ABI 7500 Fast DX, and ABI QuantStudio DX instruments compared to CCNA were 90.0% and 93.3%, 95.0% and 94.2%, and 93.8% and 95.0%, respectively. Compared to enhanced toxigenic culture, the sensitivity and specificity of the Lyra assay on the SmartCycler II, ABI 7500, and QuantStudio instruments were 82.1% and 96.9%, 89.3% and 98.8%, and 85.7% and 99.0%, respectively. Overall, the Lyra assay is easy to use and versatile and compares well to C. difficile culture methods.

메인스타팅 에어밸브는 선박에서 최초 시동을 위해 장착되는 요소로서 운전 시에는 공기를 차단하는 역할을 한다. 본 연구에서는 기 개발된 50A 메인스타팅 에어밸브의 형상을 기초로 80A 메인스타팅 에어밸브의 기초설계를 제시하였고, 80A 메인스타팅 에어밸브의 개념설계는 CATIA를 이용하여 완성되었다. 그리고 압력분포 및 속도분포등의 유동특성을 검토하기 위해서 유동해석을 수행하였고, 이어서 FSI를 이용한 구조해석을 수행하였다. 이상의 수치해석을 위하여 ANSYS 및 ANSYS CFX 프로그램을 이용하였다. 밸브 몸체의 과도한 중량은 인접 구조요소의 강도를 저해시킬 수 있고 유동특성에도 좋지 못한 영향을 줄 수 있다. 본 논문에서는 80A 밸브의 경량화 설계를 강도성능의 요구조건을 고려하여 제시하였다. 최종 제시한 밸브는 7kg의 경량화를 이루었고 최대응력도 설계기준을 만족시켰다. The role of a main starting air valve is to supply compressed air to the diesel engine for starting the stopped diesel engine of a ship and cut off the air during normal operation. In this study, the main starting air valve with 80mm size was designed based on the developed valve with 50mm size. The concept design of the 80A main starting air valve was completed by using CATIA. Then, fluid analysis was performed to investigate the flow characteristics such as pressure and velocity distribution. Sequentially, structural analysis using FSI was performed. In this study, ANSYS CFX and ANSYS Workbench are utilized. The heavy weight of the body can deteriorate the strength performance of neighbor elements, leading to undesirable effect on flow characteristics. Thus, in this research, a lightweight design of the body was suggested satisfying strength requirement. The weight of the suggested design was reduced by 7kg, and the strength satisfied its requirement.

Journal Article What Progress in Nutrition? Get access R. R. Williams R. R. Williams Research Corporation New York Search for other works by this author on: Oxford Academic PubMed Google Scholar Nutrition Reviews, Volume 5, Issue 9, September 1947, Pages 257–258, https://doi.org/10.1111/j.1753-4887.1947.tb04238.x Published: 01 September 1947

Homebased Workers May Appear to Be Independent but in Most Cases They Are Not ● This issue of SEEDS is one of several forthcoming editions that will focus on promoting the economic empowerment of women workers in selected occupations that employ large numbers of low-income women around the world (e.g., homebased work, street vending, waste recycling). Each will begin with a global overview of the situation of women workers in the selected occupation or trade and an analysis of the common obstacles they face. This will be followed by a description of the common strategies that have been developed by programs operating in a variety of settings to help these women overcome the constraints, both traditional and modern, inherent in these occupations. This issue focuses on the situation of homebased workers worldwide.