Publications from 2021 to 2026
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Bioengineered polycaprolactone nanofibers co-loaded with RGD and asiatic acid for dentin-pulp regeneration.
1Valorization of agricultural and industrial wastes in geopolymer foam concrete, a ternary binder approach using corncob ash, red mud, and fly ash
Eco-sustainable fabrication of copper oxide nanoparticles from Barleria longiflora: Implications for water treatment and cancer therapeutics
2Integrated biohydrogen production systems: Advances, synergies, and pathways to a circular hydrogen economy
ROS-responsive drug delivery systems: Harnessing redox biology for targeted therapies.
Reactive oxygen species play an integral role in physiological signaling but contribute to pathology when dysregulated. Elevated ROS levels in diseased tissues such as tumors, inflamed sites, and ischemic regions present unique biochemical triggers for targeted drug delivery. Furthermore, strategies utilizing exogenously generated ROS (e.g., via photodynamic action) provide an alternative route for spatiotemporal control. This review summarizes recent advances in ROS-responsive systems, beginning with the chemistry of ROS-cleavable linkers and the design of nanocarrier platforms capable of spatiotemporally controlled release. The integration of these carriers with theranostic functions is highlighted as a strategy to enhance selectivity and reduce systemic toxicity. Applications across oncology, inflammatory disorders, ischemia-reperfusion injury, and regenerative medicine illustrate the breadth of therapeutic potential. Key design considerations including sensitivity thresholds, payload compatibility, and surface functionalization are discussed alongside translational challenges such as stability, reproducibility, and scalability. Emerging opportunities, notably patient-specific redox profiling and biosensor-guided adaptive delivery are identified as promising routes to clinical translation. By bridging redox biology with materials science and nanomedicine, ROS-triggered drug delivery platforms demonstrate the capacity to exploit endogenous oxidative cues for improved therapeutic precision and safety, positioning them as a transformative approach in the development of next-generation controlled release systems.
Read more3Deciphering mechanistic and therapeutic insight of pyrazolopyrimidines into MRSA suppression: comprehensive in vitro and in vivo study.
Optimization of flower-like cobalt phosphate hydrate-double transition metal MXene composite electrodes for supercapattery
2C2DEEP-OT: Utilizing Multi-Agent Deep Reinforcement Learning Algorithm and Optimized Attentive Transformer Network for Cervical Cancer Detection
Synthesis and characterization of MgFe2O4@n-Pr@AHNA-Pd MNPs as efficient and recyclable catalysts for the homogeneous synthesis of tetrazole derivatives
1Next-generation hydrogel dressings: Cargo for peptides, genes, nucleic acids, proteins, growth factors targeting diabetic wounds.
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