Comprehensive Oncological Center – Veliko Turnovo

Diabetes mellitus – type 2 (DM2) is a hypercoaguable state with enhanced platelets (PLTs) activation and increased clotting factor production. Simultaneously, the fibrinolytic cell system is inhibited due to formation of clots with high resistance to fibrinolysis. The stages of PLTs "activation" have been well-characterized microscopically, morphometrically and nanomechanically (by light microscope, transmisiion electron microscope - TEM, scanning electron microscope - SEM and atomic force microscope - AFM). Thrombocytes in "acivated" (pro-coagulant) state play central role in two main biological processes: hemostasis and repair of vascular vessels. Pro-coagulant PLTs participate in generation of thrombin and in development of fibrin fibers in the clot matrix. Enhanced PLTs reactivity in dibetic- (diabetes mellitus - DM2) patients is considered as a "pro-thrombotic" state. In the retrospective- and prospective- studies on the topic, the higher are the PLTs' hematometrical indices: PLTs (count), MPV (mean platelet volume), PDW (platelet distribution width), PCR (plateletcrit), as well as PLTs/Ly ratio. The PLТs parameters/indices are usefull biomarkers in early diagnosis and prognosis of DM2. The precise studies of PLTs' state of activation during DM2 might be useful for creation of new diabetes (DM2) treatment strategies and effective medicines. Using the amount of blood glucose, attached to hemoglobin (HbA1c values) as markers of glycemic control in diabetic patients, researchers have observed association between MPV and medications as Insulin, Metformin, sulphonyl ureas. Computational modellng of PLTs' activation in DM2 is also a controlling factor for thrombocyte distribution and margination in bood vessels, associated with micro- and macrovascular disease in DM2. PLTs-derived miRNAs are novel molecular biomarkers for diagnosis and prognosis of DM2, insulin resistance and diabetes complications. We have proposed (2010) oleic acid (OA) as a substance suppressing "PLT hyperactivation" and inhibiting “thrombocyte aggregation”. Antiplatelet agents, natural plant products including, could be effective in the prevention and the secondary treatment of micro- and macrovascular complications in the type 2 Diabetes mellitus. Our proposal on following up of a combination of hematological-, hemorheological- and hemostatic parameters (indices) as a new way in diagnosis, treatment, predicting and management of DM2 and its related vascular complications, probably could be more explored in future studies.

In this demo the basic text mining technologies by using RapidMining have been reviewed. RapidMining basic characteristics and operators of text mining have been described. Text mining example by using Navie Bayes algorithm and process modeling have been revealed.

In this paper the model PER (Process Entity Relationships) for semantic data modeling is presented, based on process and architectural approach. Terms, symbols and conventions used are explained. The levels of the model were described, and some example models are given.

Nowadays computer 3D technologies are topic of present and are field of state-of-the-art research and dynamical development. Their main goal is to provide the observers of computer simulated environments with 3D perception. 3D computer display technologies play base role in this three-dimensional visualization. This report presents the results from the investigations into a multiview autostereoscopic 3D display technology developed by Philips 3D Solutions with the purpose of creating images and video for these kind devices. This paper is financed by project: Creative Development Support of Doctoral Students, Post-Doctoral and Young Researches in the Field of Computer Science, BG 051PO001-3.3.04/13, European Social Fund 2007--2013, Operational Programme Human Resources Development.

Th is is by no means an exhaustive review of all recent Bulgarian publications in the field.However, an attempt is made at a representative selection.Th e chronological range is approximately set between the (Late) Bronze Age and Late Antiquity.Th e grouping of the titles is both according to subject and (more or less) in chronological order.During the last few years several publications of quite recent discoveries appeared, as well as some awaited studies on monuments and sites known for a long time.

In the paper are offered basic type decisions and through a diversity of examples from different areas of application their wide range is illustrated. For the purpose the model of d-r Tujarov is presented and used in it.

Despite some publications on Parkinson’s disease prevalence in Bulgaria, its frequency in the country still remains uncertain. Earlier studies in Bulgaria were carried out on large population groups and were based on medical records without further diagnostic confirmation. The aim of the present study was to perform an epidemiological investigation on Parkinson’s disease in Bulgaria, using strict diagnostic criteria in an attempt to obtain a more accurate estimate of its frequency in this country. We studied the prevalence of Parkinson’s disease in two small regions of Bulgaria. Cases were ascertained by the medical records and confirmed by personal examination. The prevalence of Parkinson’s disease was found to be 164.2 per 100,000 with 47 cases in the first region and 169.8 per 100,000 with 155 cases in the second region. Based on two small population studies, the prevalence ratio in different parts of Bulgaria is not significantly different and is similar to other European countries.

This book is the outcome of several years of contact with young intellectuals in China and, it must be admitted, is only partly the result of conscious planning and preparation. Some of the following description and analysis is due to accidents of history that placed me in China in certain places at certain times and this can be seen as both a strength and a weakness of the project. Readers must decide for themselves the relative degree of each after considering the evidence.