Crest Middle School

The key to the unlimited proliferation of cancer cells lies in their ability to maintain telomere length, thereby evading the normal mechanisms of cellular senescence and death. Cancer cells mainly sustain or lengthen telomeres through telomerase activation and telomere elongation replacement mechanisms. The former is targeted at clinical trials of telomerase inhibitors (Imetelstat), which are currently ongoing. However, there are still many unsolved mysteries regarding the specific molecular mechanism of the Alternative Lengthening of Telomeres (ALT)pathway, which limits the development of anti-cancer drugs targeting this pathway. By reviewing relevant literature, this review will discuss the progress and new discoveries of this mechanism in recent years. The research conclusion indicates that although progress has been made in inhibiting key targets of the telomeric substitution elongation pathway (such as topoisomerase III) and developing molecular tools, and a quality control mechanism has been discovered for ALT cancer cells, the specific delivery and toxicity management of targeted drugs remain challenges in clinical translation.

With the rapid advancement of consumer electronics like smart wearables and flexible displays, the demand for portable, deformable energy systems has surged. Traditional rigid solar cells and ITO electrodes fail to meet flexibility requirements, driving the development of FTEs for OPVs. This study systematically reviews three major FTE material systems: metal grids, silver nanowires, and conductive polymers. Metal grids offer high conductivity (down to 0.5 /sq) and low cost, but face surface roughness issues. Silver nanowires form flexible conductive networks with 90% transmittance and retain over 94% PCE after 1000 bends, yet suffer from dispersion and cost challenges. Conductive polymers have good processability and achieve 7.7% PCE in OPVs, comparable to ITO, but require harsh treatment. Performance data shows optimized FTEs enhance OPV efficiency: modified Ag grid OPVs reach 1.36% PCE, AgNW-based small-area OPVs hit 16.1%, and conductive polymer OPVs match ITO efficiency. Suggestions include optimizing sintering for metal grids, developing green synthesis for AgNWs, and milder treatments for polymers.

Over half of all Americans seek health-related information online, yet the quality of this digital content remains largely unregulated and variable. The DISCERN score, a validated 15-item instrument, offers a structured method to assess the reliability of written health information. While expert-assigned DISCERN scores have been widely applied across various disease states, whether artificial intelligence (AI) can automate this evaluation remains unknown. Specifically, it is unclear whether AI-generated DISCERN scores align with those assigned by human experts. Our study seeks to investigate this gap in knowledge by examining the correlation between AI-generated and human-assigned DISCERN scores for TikTok videos on Irritable Bowel Syndrome (IBS). A set of 100 TikTok videos on IBS previously scored using DISCERN by two physicians was chosen. Sixty-nine videos contained transcribable spoken audio, which was processed using a free online transcription tool. The remaining videos either featured songs or music that were not suitable for transcription or were deleted or were not publicly available. The audio transcripts were prefixed with an identical prompt and submitted to two common AI models-ChatGPT 4.0 and Microsoft Copilot for-DISCERN score evaluation. The average DISCERN score for each transcript was compared between the AI models and with the mean of the DISCERN score given by the human reviewers using Pearson correlation (r) and Kruskal Wallis test. There was a significant correlation between human and AI-generated DISCERN scores (r = 0.60-0.65). When categorized by the background of the content creators-medical (N = 26) versus non-medical (N = 43), the correlation was significant only for content made by non-medical content creators (r = 0.69-0.75, p < 0.001). Correlation between ChatGPT and Copilot DISCERN scores was stronger for videos by non-medical content creators (r = 0.66) than those by medical content creators (r = 0.43). On linear regression, ChatGPT's DISCERN scores explained 55.6% of the variation in human DISCERN scores for videos by non-medical creators, compared to 8.9% for videos by medical creators. For Copilot, the corresponding values were 47.2% and 9.3%. AI models demonstrated moderate alignment with human-assigned DISCERN scores for IBS-related TikTok videos, but only when content was produced by non-medical creators. The weaker correlation for content produced by those with a medical background suggests limitations in current AI models' ability to interpret nuanced or technical health information. These findings highlight the need for further validation across broader topics, languages, platforms, and reviewer pools. If refined, AI-generated DISCERN scoring could serve as a scalable tool to help users assess the reliability of health information on social media and curb misinformation.

The ability to use English effectively has become a critical factor for success in the modern American economy. For English language learners (ELLs), academic achievement requires more than conversational fluency; it involves acquiring advanced literacy and communication skills that allow them to engage with rigorous content, develop higher-order thinking, and participate in collaborative learning environments. The objective of this research is to examine the challenges and opportunities facing ELLs in meeting college- and career-ready standards while exploring instructional strategies that enhance their academic success. Specifically, the study seeks to understand how teachers can leverage students’ cultural and linguistic resources to support both content mastery and language development across subject areas. The methodology applied in this research draws upon a qualitative review of existing standards, instructional models, and theoretical frameworks. Bourdieu’s Theory of Cultural Capital serves as a guiding lens for analyzing how students’ prior knowledge, cultural background, and linguistic assets can be mobilized as strengths in the classroom. State-level standards for English Language Arts (ELA) and other disciplines were examined to identify the advanced competencies required for student progression. In addition, instructional practices such as scaffolding, sheltered instruction, and dual immersion were analyzed to determine how they address the dual challenge of language acquisition and academic content learning. Findings emphasize that teachers play a pivotal role in identifying the language demands of academic tasks and providing targeted supports. Effective strategies include scaffolding content, organizing peer interactions, and intentionally linking instruction to students’ native language skills and cultural experiences. The study underscores that states must ensure alignment among curriculum, assessment, and professional development to sustain equitable opportunities for ELLs. By integrating cultural capital into instruction, educators can foster independence, critical thinking, and readiness for postsecondary success.&lt;p&gt; &lt;/p&gt;&lt;p&gt;&lt;strong&gt; Article visualizations:&lt;/strong&gt;&lt;/p&gt;&lt;p&gt;&lt;img src="/-counters-/soc/0424/a.php" alt="Hit counter" /&gt;&lt;/p&gt;

In a company, entrepreneurs as core figures need to make decisions on various matters. However, cognitive biases, one of the most common biases among entrepreneurs, affect their traits and decisions, significantly influencing company performance. This article studies three common cognitive biases: overconfidence bias, heuristic bias, and status quo bias. These biases greatly impact the quality of entrepreneurial decisions, thereby affecting company performance both positively and negatively. For the negative impacts, the article analyzes these biases and proposes strategies to help entrepreneurs better avoid their adverse effects, thus improving company performance.

Long-standing special education teacher (SET) shortages and declining enrollment in SET preparation programs in the United States (U.S.) have resulted in a significant number of alternatively-certified SETs in classrooms, particularly in poverty-impacted schools. As a result, the least experienced teachers often serve in schools with historically underserved students. It is critical to understand the needs and experiences of these teachers to support them better. This qualitative study examined twelve first- and second-year, alternatively certified special educators’ experiences in inclusive classrooms in poverty-impacted schools in the U.S. Participants completed a brief survey of demographics and daily experiences, two semi-structured interviews, and member checks. Results were analyzed to understand participants' experiences teaching within inclusive settings. Key themes - an impossible task, feeling like they worked in “someone else’s stadium,” and a preference for separate settings - underscore the complexities of implementing inclusive education effectively. Recommendations for special and general education teacher and administrator preparation and ongoing support are provided.

In order to explore the impact of the multi-school zoning policy on the level of educational equity, this article uses a questionnaire survey to collect data on parents demographics, perception of the policy, its impact, satisfaction levels, and suggestions for improvement. The study finds that the multi-school zoning policy has improved the equitable allocation of educational resources to a certain extent, alleviated the pressure on popular schools, and increased the quality of education in other schools. However, there are also some problems during its implementation. For example, parents satisfaction with school choice is low, and some parents believe that the multi-school zoning policy does not fairly consider the interests of all students. Based on the survey results, this article puts forward some recommendations for improving the multi-school zoning policy, with the aim of further promoting educational equity.

With the gradual implementation of the new college entrance examination, Sichuan, as the fifth echelon of the reform, will also officially open the first new college entrance examination this year. However, the change of question type and the increase of difficulty of test questions also follow. The conic curve test is one of the key and difficult points in high school mathematics, and it is also the pride of the new college entrance examination. The knowledge of conic curve is an important part of plane analytic geometry, and it is also a typical combination of number and shape. It is self-evident that it contains mathematical ideas. Based on the existing relevant research, this paper studies the conic curve test questions in the national volume of the new college entrance examination from 2019 to 2024. The content of this paper can be divided into three parts: The first part introduces the research background, research questions, and expounds the purpose and significance of the research. This paper introduces the related research of many scholars, including the content of conic curve teaching materials, problem-solving errors, problem-solving strategies, teaching and so on. It also expounds Polya s problem-solving theory and the conic curve content of the new college entrance examination, based on which the analysis is carried out. The second part, as the core part of this paper, studies the six-year conic curve test questions from two perspectives. Firstly, it is the requirement of mastering the conic curve in the new curriculum standard. Secondly, it is the analysis of the proportion of test questions and scores, the test points and difficulty of the test questions. Finally, it is a comprehensive analysis. The collected real questions are sorted out, classified and summarized into the corresponding questions, and the corresponding problem-solving analysis and strategies are given. The third part summarizes the work of this paper, and puts forward some suggestions for teachers teaching and students learning.

Many courses Physical Education Teacher Education (PETE) majors take are all considered valuable and important to the PETE majors before entering the profession of teaching physical education (PE). The practicum course is probably the most important for PETE majors. The practicum course typically consists of an elementary, middle school, and high school teaching experience. This study aimed to investigate PETE majors’ perceptions of teaching before (pre) and after (post) they participated in a high school PE practicum. For this study, 14 senior PETE majors were interviewed before and after participating in their high school PE practicum. It was generally found that before participating in the practicum, the PETE majors were concerned about classroom management issues and dealing with the unknown before teaching. After the practicum, the students felt that being prepared with the lessons was important for their success, and the PETE students weren’t anxious regarding the student teaching experience. These findings affirm the practicum’s importance in the PETE majors’ preparation to teach PE.

With the introduction of peak carbon, carbon neutrality, new development concept and the concept of community of human destiny, as well as the increasing prominence of energy and environmental protection issues, people gradually focus on solving the related problems. The article focuses on the principle and wireless charging technology on the development trend of new energy vehicles, sorting out the working mode, working principle, research results and trends on wireless charging technology ; introducing the advantages and disadvantages of electromagnetic induction, magnetic coupling resonance and radio wave wireless charging technology as well as wireless charging technology is located within an electric field and related workings. The advantages and disadvantages of wireless charging technology in electric field coupling and the related principles are summarised, and describes future trends regarding wireless charging technology.