Croma Pharma (Austria)

Hyaluronic acid (HA) dermal fillers represent a cornerstone of modern esthetic medicine, providing a minimally invasive solution for facial volume restoration and skin rejuvenation. However, the diversity of available products, each utilizing distinct crosslinking technologies, presents a challenge for objective comparison and clinical decision making. This study introduces a scientific framework to evaluate and categorize the physicochemical properties of HA fillers based on two key parameter groups: dynamic parameters (e.g., rheology and gel content) and consistency parameters (e.g., extrusion force, water uptake, and gel particle size). Using standardized methodologies, 23 commercially available fillers from five major manufacturers were analyzed, enabling cross-technology comparisons. The findings reveal how specific crosslinking approaches influence the rheological behavior, handling characteristics, and potential clinical applications. By offering an integrated and reproducible assessment, this work helps practitioners select the most suitable filler for individualized treatment plans and encourages manufacturers to enhance product transparency through harmonized testing protocols.

Abstract In this paper, the design and optimization of a circularly polarized antenna based on two crossed dipoles in phase quadrature for Global Navigation Satellite System (GNSS) wide band application has been investigated. The proposed design is single fed and relies on parasitic structures to achieve wide band coverage on the GPS standard bands L1 (1559–1610 MHz) and L5 (1164–1189 MHz). Full-wave simulations have been used to compute the radiation properties and the impedance of the antenna. A prototype was manufactured, and good agreement has been observed between the simulated results and measurement for both radiation pattern and reflection coefficient. The antenna achieves a −10 dB impedance bandwidth of $56.97\%$ covering the band 1164–1610 MHz, and an axial ratio that covers the L5 band ranging between 7 dB and 2.8 dB from 1.164 GHz to 1.3 GHz while maintaining a value below 2.7 dB across the entire L1 band. The antenna occupies a volume of $\,99\, \,\times\,99\, \times 50$ mm3. It has been tested in real conditions during the 23rd French National Microwave Days (JNM) student competition. A GNSS signal receiver has been connected to the antenna. The antenna has been evaluated based on the number of connections it could achieve over a duration of 30 s.

Colloids, polymers, gels, and biological materials are widely used for numerous technological applications. The design, fabrication, and understanding of the physico-chemical properties of such (bio)materials, however, represent a challenge for scientists and technologists. This review is a concise update of the latest achievements in surface and bulk analytical techniques applied to biomaterials and soft matter systems. Specific emphasis is devoted to their structural, mechanical, surface, and chemical properties. The review introduces the basics of atomic force microscopy (AFM) and discusses its combination with optical microscopies and spectroscopic techniques. In particular, we report the AFM combination with fluorescence, confocal microscopy, stimulated emission depletion, Raman, and infrared spectroscopy. The review highlights the impact and the potential applications of the combination of such experimental techniques on current problems and questions related to material and polymer science, cell biology, biochemical engineering, and protein chemistry. This review is an accessible introduction to AFM for the newcomer and a source of new experimental information for the experienced researcher.