DB Biotech (Slovakia)

Neurodegenerative diseases are pathological processes characterized by neuronal death and morbid evolution leading to occupational injury and serious neuropsychiatric disorders. The natural course of neurodegenerative diseases does not show regression of symptoms or cure and current treatments are far from producing a real improvement in the quality of patient’s life. Several studies have been conducted in an attempt to find causes of cellular disturbances focusing new pharmacological targets priming to successful therapeutic interventions. Studies have been directed to investigate possible changes in energy metabolism pathways. Indeed, some disturbances in glycolytic pathway and mitochondrial dysfunctions have been associated with Huntington’s Disease and other neurodegenerative diseases and are often related to the events of cell death. In this section, an overview of the energy metabolism pathways will be presented and the particular aspects of energetic metabolism in Huntington’s Disease will be discussed.