Dayton Metro Library

Postconstruction problems—such as low foundation strength, postconstruction settlement, and extended settlement durations—must be addressed when building structures on peat foundations. In previous engineering practice, inorganic binders were used primarily to stabilize peat foundations. However, peat stabilized with inorganic binders exhibits relatively low strength and can result in substantial carbon emissions. Peat from the Dali region of the Yunnan Province was investigated in this study. Unconfined compressive strength (UCS) and calcium carbonate precipitation rate tests were conducted to examine the changes in UCS. The study focused on combining the environmentally friendly enzyme-induced carbonate precipitation (EICP) technique with various proportions of cement, gypsum, fly ash, and sand. The results were compared with the strength characteristics of peat stabilized using EICP alone or inorganic binders (such as cement, gypsum, and fly ash). The results showed that the combination of EICP with inorganic binders improved the UCS of stabilized peat considerably, with varying degrees of strength enhancement depending on the binder used. The combination of EICP with 10% (142 kg/m3) cement achieved the best results, yielding a UCS 12.5 times higher than that of peat stabilized with 10% (142 kg/m3) cement alone and 2.6 times higher than that of peat stabilized with EICP alone. The addition of sand was found to inhibit the strength development of stabilized peat. The calcium carbonate precipitation rate of peat stabilized using the EICP–inorganic binder combination was considerably higher than that of peat stabilized with EICP alone, indicating that inorganic binders could promote the urease reaction to generate calcium carbonate, thereby enhancing the strength of the stabilized peat. This study confirmed the superiority and feasibility of combining EICP with inorganic binders for peat stabilization, offering a new method for practical engineering applications in the field.

G-protein-coupled receptor-associated sorting protein 1 (GPRASP1) plays an important role in tumorigenesis. However, GPRASP1 specific role has not been clarified in head and neck cancer (HNC). HNC RNA sequencing (RNA-seq) datasets, DNA methylation data, somatic mutation data, copy number variation (CNV) data, and corresponding clinicopathologic information were acquired from the Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. A comprehensive evaluation was performed to explore the relationship of GPRASP1 expression with clinicopathologic characteristics, CNV, and DNA methylation. Additionally, we employed HNC tissue microarray (TMA) to further confirm the relation between GPRASP1 expression and clinical features. Then, we systematically associated the GPRASP1 with immunological properties from numerous perspectives, such as immune cell infiltration, immune-related pathways, immune checkpoint inhibitors (ICIs), immunomodulators, immunogenicity, and immunotherapy. Analyzing TCGA, GEO, and TMA datasets, GPRASP1 is significantly down-regulated in HNC compared to normal tissues. The expression of GPRASP1 is significantly negatively correlated with clinical features (perineural invasion, histologic grade, T stage, and TNM stage), and is an independent predictor of favorable prognosis, regardless of other clinicopathological features (HR: 0.42, 95% CI 0.20-0.91, p=0.028). The etiological investigation found that the abnormal expression of GPRASP1 was related to DNA methylation, not CMV. Subsequently, the high expression of GPRASP1 was significantly correlated with immune cell infiltration (CD8+ T cell, tumor infiltrating lymphocyte), immune-related pathways (cytolytic activity, check-point, human leukocyte antigen), ICIs (CTLA4, HAVCR2, LAG3, PDCD1, and TIGIT), immunomodulators (CCR4/5, CXCL9, CXCR3/4/5), and immunogenicity (immune score, neoantigen, tumor mutation burden). Finally, immunophenoscore and tumor immune dysfunction and exclusion analysis demonstrated that GPRASP1 expression levels can accurately predict the immunotherapeutic response. GPRASP1 is a promising candidate biomarker that plays a role in the occurrence, development, and prognosis of HNC. Evaluating GPRASP1 expression will aid in the characterization of tumor microenvironment infiltration and orient more efficient immunotherapy strategies.

The Dayton, OH, Byrne Criminal Justice Innovation Program (BCJI) site embarked on a multi-sector partnership effort focused on the reduction of opioid addiction, overdose deaths, and property crime directly associated with opioid users in the target neighborhood. Within the context of a broader effort, a community-based, non-arrest strategy directed at opioid addicts was developed, utilizing a motivational interviewing program intervention. The planned set of program interventions had two effects: first, more opioid addicts entered treatment as a result of the community engagement effort. Second, information gleaned from the ongoing dialogue with addicts helped accelerate several community-based efforts. These included opening a site for medication-assisted treatment and a newly formed collaboration between the police department and a local community service organization that expanded outreach to those who had been saved by naloxone treatment after an overdose. The BCJI program in Dayton reinforced the idea that crime reduction must be embedded in a community collaboration. The BCJI process enabled a shared policy and program space in which participants could bring their contacts, knowledge, and skills together. The final set of program innovations plied in Dayton exemplified the goals and aspirations of the BCJI program.