De Beers (Canada)

BackgroundWe previously showed in animals that transpulmonary driving pressure (PL) can be estimated during Neurally Adjusted Ventilatory Assist (NAVA) and Neural Pressure Support (NPS) using a single lower assist maneuver (LAM). The aim of this study was to test the LAM-based estimate of PL (PL_LAM) in patients with acute respiratory failure.MethodsThis was a prospective, physiological, and interventional study in intubated patients with acute respiratory failure. During both NAVA and simulated NPS (high and low levels of assist), a LAM was performed every 3 min by manually reducing the assist to zero for one single breath (by default, ventilator still provides 2 cmH2O). Following NAVA and NPSSIM periods, patients were sedated and passively ventilated in volume control and pressure control ventilation, to obtain PL during controlled mechanical ventilation (PL_CMV). PL using an esophageal balloon (PL_Pes) was also compared to PL_LAM and PL_CMV. We measured diaphragm electrical activity (Edi), ventilator pressure (PVent), esophageal pressure (Pes) and tidal volume. PL_LAM and PL_Pes were compared to themselves, and to PL_CMV for matching flows and volumes.ResultsTen patients were included in the study. For the group, PL_LAM was closely similar to PL_CMV, with a high correlation (R2 = 0.88). Bland–Altman analysis revealed a low Bias of 0.28 cmH2O, and 1.96SD of 5.26 cmH2O. PL_LAM vs PL_Pes were also tightly related (R2 = 0.77).ConclusionThis physiological study in patients confirms our previous pre-clinical data that PL_LAM is as good an estimate as PL_Pes to determine PL, in spontaneously breathing patients on assisted mechanical ventilation.Trial registration The study was registered at clinicaltrials.gov (ID NCT05378802) on November 6, 2021

<p>We present new thermochemical models of the lithosphere and upper mantle beneath the Superior craton and surrounding regions. The study area is dominated by the Archean Superior Province, surrounded by Proterozoic orogenic belts such as the Trans-Hudson Orogen (THO) to the north and the Grenville Orogen to the southeast. Portions of the Rae and Hearne cratons north of the THO are also studied, as is the Mid-continent Rift to the south. Over a period of ∼3 Ga, the region has seen assembly and modification by accretionary and orogenic events, periods of rifting, and the influence of a number of mantle hotspots. Here, we use a probabilistic inverse method to jointly invert Rayleigh wave dispersion data, Vp data, geoid anomalies, surface heat flow, and absolute elevation. The output is a 3D model of the seismic, temperature, bulk density, and compositional structure of the whole lithosphere beneath the Superior craton.</p><p>The resulting model will provide new opportunities for joint studies of the structure of the upper mantle and will shed light on the thermal and compositional variations beneath the region. In this presentation, we will discuss the results from our model and several robust features that carry important geological and geodynamical implications for this region.</p>

Abstract Most kimberlite maar-diatreme volcanoes erupted during the Tertiary or earlier and therefore their tephra rings and, less often, their near-surface diatreme-filling deposits have usually been eliminated by erosion. Poorly eroded Quaternary non-kimberlite maar-diatreme volcanoes, especially those of mafic and ultramafic magma types, have the same diatreme size range (diameter and depth) as kimberlite pipes and show similar internal volcaniclastic diatreme lithofacies. In addition, these young volcanoes often have a more or less preserved tephra ring consisting of hundreds to perhaps a few thousand thin tephra beds. Volcanological analyses of the xenolith-rich primary volcaniclastic deposits both within these diatremes and in the tephra ring beds reflect phases of explosive pipe growth and are of convincingly phreatomagmatic origin. The similarities between non-kimberlite pipes and kimberlite pipes suggest to some researchers that phreatomagmatic processes were also responsible for pipe excavation processes in kimberlite maar-diatreme volcanoes. In contrast, other researchers have suggested that kimberlite maar-diatreme volcanoes were emplaced largely by magmatic processes as a consequence of exsolution and the explosive expansion of juvenile volatiles. We therefore analysed and compared some key geological features of kimberlite and ultrabasic to basic ‘basaltic’ maar-diatreme volcanoes to determine similarities and differences with respect to their emplacement behaviour.

Data are corrected for mass spectrometer backgrounds, discrimination, and radioactive decay, but not for isotopic interferences.