- Conference Article
- 10.1183/13993003.congress-2025.pa1720
The impact of severe COVID-19 pneumonia on the pulmonary and systemic circulation based on flow laws
- Sep 27, 2025
- Tibor Endre Nagy + 6 more +6
<bold>Background:</bold> According to data from COVID-19 pandemic, mortality rate was 1-3%. The severity of x-ray and pathology resulted in proportional circulatory impairment. <bold>Aims:</bold> We tried to clarify the cause of heart failure in patients who died of COVID-19 infection in our ICU. We examined the pressure load on the right ventricle as a probable cause of death. <bold>Method</bold> Using flow laws, a double torus-shaped blood circulation model can be developed. <fig><object-id>erj;66/suppl_69/PA1720/F1</object-id><object-id>F1</object-id><object-id>F1</object-id><graphic></graphic></fig> Knowing the pulmonary and systemic circulation times (t<sub>2π</sub>), at a given velocity (v) and cross-sectional area (A), the change in <italic>average</italic> blood pressure (P) and blood volume (V) of our patients can be calculated together with their circumferences (C) [1]. <bold>Results:</bold> In connection with the radiological and histological images, we found an average right ventricular pressure of 34 mmHg in our 18 patients by echocardiography. This pressure increase, according to the model, causes a 23% pressure drop in the systemic circulation, which led to shock. <bold>Conclusions:</bold> This fluid mechanics approach may be suitable for demonstrating pathological processes occurring in the circulation of COVID-19 patients. This supports our therapeutic decisions against circulatory collapse. Based on this model, a mortality risk score could be created for this disease. 1. Nagy,T.E. Human blood circulation model based on flow laws of intensity and continuity in relation to earth’s surface gravity. 2023. J Lung Pulm Respir Res.
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