Derma Consult (Germany)

Abstract Mycosis fungoides (MF) is a rare cutaneous T cell lymphoma that, in its early stages, can closely mimic eczema and psoriasis in both clinical appearance and histopathologic features, leading to frequent misdiagnosis, inappropriate treatment, and delayed care. Reliable adjunctive biomarkers are lacking, underscoring the need for improved diagnostic strategies. We developed a biomarker discovery framework based on bulk RNA sequencing of skin biopsies (19 MF, 112 psoriasis, 105 eczema), which identified seven candidate diagnostic genes. RT-PCR analysis in FFPE tissue specimens from 65 MF and 101 eczema/psoriasis samples verified LCK and HOMER1 as robust discriminator genes. A logistic regression model based on LCK and HOMER1 gene expression differentiated MF from psoriasis and eczema with 91% sensitivity and 94% specificity. Independent validation on 7 additional international cohorts (MF n=58, eczema/psoriasis n=55) confirmed robust performance. Spatial and single-cell transcriptomic analyses revealed biological underpinnings of classifier accuracy: LCK was enriched in malignant and specific T cell subsets in MF, whereas HOMER1 was confined to keratinocytes in eczema and psoriasis but nearly absent in MF. Case studies demonstrated that the classifier identified MF in routine biopsies earlier than histopathology. This molecular diagnostic approach enables earlier and more reliable distinction of MF from common inflammatory dermatoses, offering a clinically applicable tool to reduce diagnostic uncertainty, accelerate appropriate treatment, and might improve patient outcomes. One Sentence Summary A two-gene classifier reliably distinguishes mycosis fungoides from eczema and psoriasis, enabling early and accurate diagnosis.

Interoperability is the key to implementing a wide range of energy systems applications. It involves the seamless cooperation of different methods and components. With smart energy systems, interoperability faces challenges due to integrating different approaches and technologies. This includes dealing with heterogeneous approaches with various communication protocols and data formats. However, it is essential for smart energy systems to carry out thorough interoperability tests. They are usually diverse, and challenging, thus requiring careful consideration of compatibility issues and complex integration scenarios. Overcoming these challenges requires a systematic approach that includes thorough test planning, rigorous testing, and continuous test monitoring. Although numerous testing approaches exist, most are more developed at the component/device level than at the system level. Consequently, there are few approaches and related facilities to test the interoperability of smart energy approaches and solutions at the system level. This work analyses existing interoperability test concepts, identifies enablers and the potential for harmonisation of procedures, and proposes further developments of these approaches.

Abstract This paper describes the design, construction and operation of a test rig for jetted conductors in soft clays. The rig was designed to produce repeatable tests under controlled conditions to evaluate the influence of operational jetting procedures on the conductor performance just after installation and at different periods after installation (set-up effect), underdifferent loading conditions. The test drilling rig consists of two main parts: an isostatic supporting structure and a jetting bottom hole assembly (BHA). All parts were designed to emulate real operational conditions found in offshore drilling rigs on a more manageable scale. A 7" (177.8 mm)OD and 6 m long conductor was used for this purpose and a 3.5" (88.9 mm) commercial drilling motor was fitted inside it. The design was such that several combinations of values of bit stick-out and flow rate are easily obtained in the field. The test rig showed up as a powerful tool for geotechnical research in which the influence of some drilling parameters on the axial and lateral bearing capacity of the conductor, such as: bit stick-out, flow rate and set-up can be evaluated.

Einleitung In der japanischen Esskultur „Hara hashi bu“ wird ca. 1/5 des Magens bewusst leer gelassen. Einen vergleichbaren Effekt kann eine Kompressionsbandage (im Folgenden „Efe-Bandage“) vermitteln, die durch Druck von außen auf das Epigastrium eine Magenluftkompression hervorruft. Diese Bandage ist seit 2017 als Medizinprodukt der Klasse I erhältlich.

Die 90 sec. Backstory geht auf den Unternehmensberater, Kulturanthropologen und zweifachen TED-Sprecher Michael Margolis (2007) zuruck, der Unternehmen wie Facebook und Google im Einsatz von Storytelling berat. Man versteht darunter eine in ca. 90 Sekunden erzahlte Kurzgeschichte uber eine Person oder ein Unternehmen, deren Ziel es ist, in kurzer Zeit Vertrauen beim Gegenuber aufzubauen. Die Geschichten, die wir uber uns bzw. die ein Unternehmen uber sich erzahlt, sind entscheidend fur das Vertrauen, das Kunden, Mitarbeiter und Offentlichkeit zu uns oder zum Unternehmen haben. Daher werden bei der 90 sec. Backstory vier Leitfragen gestellt, die die Gesprachspartner schnell zu personlichen Erzahlungen, etwa zu ihrer Biografie, fuhren. Das Vorgehen ist auch in Grosgruppenevents anwendbar, etwa wenn nach der Backstory des gesamten Unternehmens gefragt wird.

Martina Eisendle und Florian Oberforcher begleiteten ab Herbst 2017 das Vorarlberger Kinderdorf, das uberwiegend im Auftrag der Kinder- und Jugendhilfe arbeitet, durch einen Veranderungsprozess. Das fast 70-jahrige Unternehmen hat rund 300 Mitarbeitende und steht vor einem umgreifenden Generationswechsel und anderen Herausforderungen.