- Research Article
- 10.1007/s00063-025-01396-0
Development of an infusion regimen to avoid incompatibilities in adult intensive care patients
- Jan 13, 2026
- Medizinische Klinik, Intensivmedizin und Notfallmedizin
- D Meyn + 7 more +7
The concurrent delivery of multiple infusion solutions (Y-site administration) through asingle catheter lumen in intensive care patients is often unavoidable. This may lead to physicochemical incompatibilities, significantly affecting the efficacy and safety of drug therapy. The objective of this study is to develop and formulate an infusion regimen that considers the number of access points and avoids incompatibilities for adult intensive care patients. Acomprehensive literature search was conducted following the ADKA-DIVI standard concentration list for continuous infusions. Manufacturer information and databases, such as STABILIS, Kingguide, and Trissel's TM2IV Compatibility, were used to evaluate compatibility. For frequently used combinations for which no compatibility data were available, stability data on physical compatibility were compiled. Based on this, considering 34common active ingredients and their standard concentrations, a4-lumen central venous catheter (CVC) infusion regimen was developed to help avoid incompatibilities in the adult intensive care unit.
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