Duferco (Belgium)

Summary This paper deals with the notions of U-small set, U-small category, and U-locally small category (U is non-empty Grothendieck universe). We reuse the first Mizar formalization of categories contained in CAT_* series of Mizar articles in order to show the expressive power of the Tarski-Grothendieck set theory (which is the base for the Mizar Mathematical Library) in this area. We encode parts of SGA 4 by Nicolas Bourbaki.

BackgroundSafinamide is a recent multimodal antiparkinsonian drug that inhibits monoamine oxidase B and modulates the glutamatergic system with positive effects on motor and nonmotor symptoms of Parkinson’s disease (PD). This post-hoc analysis of the European SYNAPSES study provides first-time data on the use of safinamide in routine clinical practice in Belgium.ObjectiveTo describe the efficacy and safety of safinamide in Belgian PD patients in real-life conditions.MethodsPost-hoc analysis of the Belgian cohort from the European SYNAPSES trial, which was an observational, multicenter, retrospective-prospective cohort study. Patients were followed up to 12 months. Analyses were performed in the overall population and according to different criteria such as the age limit (> 75 years), presence or absence of relevant comorbidities, presence or absence of psychiatric conditions such as depression and anxiety, patients on levodopa monotherapy or levodopa in combination with other treatments, patients on rasagiline before inclusion or not.ResultsOf the 172 patients included, 29.2% were > 75 years, 58.9% had relevant comorbidities and 32.7% had psychiatric conditions. Almost all the patients reported motor (98.8%) or non-motor (86.3%) symptoms. During the study, 36.3% of patients reported drug-related reactions. The adverse drug reactions were those already described in the patients’ information leaflet. The majority were mild or moderate and completely resolved and no differences were detected between the subgroups of patients. Almost 35% of the patients demonstrated a clinically significant improvement in the UPDRS and 50% of the patients with wearing-off at baseline, did not report wearing-off anymore after one year of treatment. Patients under levodopa monotherapy compared to patients receiving levodopa combined with other antiparkinsonian treatments benefit more from safinamide treatment. Patients switched from rasagiline to safinamide seemed also to benefit more from safinamide treatment.ConclusionThe study confirms the excellent safety and efficacy profile of safinamide, particularly in more vulnerable groups of patients such as the elderly and patients with significant comorbidities or psychiatric conditions such as depression or anxiety.

Summary Józef Białas and Yatsuka Nakamura has completely formalized a proof of Urysohn’s lemma in the article [4], in the context of a topological space defined via open sets. In the Mizar Mathematical Library (MML), the topological space is defined in this way by Beata Padlewska and Agata Darmochwał in the article [18]. In [7] the topological space is defined via neighborhoods. It is well known that these definitions are equivalent [5, 6]. In the definitions, an abstract structure (i.e. the article [17, STRUCT 0] and its descendants, all of them directly or indirectly using Mizar structures [3]) have been used (see [10], [9]). The first topological definition is based on the Mizar structure TopStruct and the topological space defined via neighborhoods with the Mizar structure: FMT Space Str. To emphasize the notion of a neighborhood, we rename FMT TopSpace (topology from neighbourhoods) to NTopSpace (a neighborhood topological space). Using Mizar [2], we transport the Urysohn’s lemma from TopSpace to NTop-Space. In some cases, Mizar allows certain techniques for transporting proofs, definitions or theorems. Generally speaking, there is no such automatic translating. In Coq, Isabelle/HOL or homotopy type theory transport is also studied, sometimes with a more systematic aim [14], [21], [11], [12], [8], [19]. In [1], two co-existing Isabelle libraries: Isabelle/HOL and Isabelle/Mizar, have been aligned in a single foundation in the Isabelle logical framework. In the MML, they have been used since the beginning: reconsider, registration, cluster, others were later implemented [13]: identify. In some proofs, it is possible to define particular functors between different structures, mainly useful when results are already obtained in a given structure. This technique is used, for example, in [15] to define two functors MXR2MXF and MXF2MXF between Matrix of REAL and Matrix of F-Real and to transport the definition of the addition from one structure to the other: [...] A + B -> Matrix of REAL equals MXF2MXR ((MXR2MXF A) + (MXR2MXF B)) [...]. In this paper, first we align the necessary topological concepts. For the formalization, we were inspired by the works of Claude Wagschal [20]. It allows us to transport more naturally the Urysohn’s lemma ([4, URYSOHN3:20]) to the topological space defined via neighborhoods. Nakasho and Shidama have developed a solution to explore the notions introduced in various ways https://mimosa-project.github.io/mmlreference/current/ [16]. The definitions can be directly linked in the HTML version of the Mizar library (example: Urysohn’s lemma http://mizar.org/version/current/html/urysohn3.html#T20).

La présentation d’une vignette clinique sera l’occasion de questionner quelques empêchements à l’engagement dans une relation de couple et ce, en se référant au concept de pulsions et de destins pulsionnels tel que l’a développé S. Freud dans son article « Pulsions et destins pulsionnels ».

Summary In the article, we continue [7] the formalization of the work devoted to Tarski’s geometry – the book “Metamathematische Methoden in der Geometrie” (SST for short) by W. Schwabhäuser, W. Szmielew, and A. Tarski [14], [9], [10]. We use the Mizar system to systematically formalize Chapter 8 of the SST book. We define the notion of right angle and prove some of its basic properties, a theory of intersecting lines (including orthogonality). Using the notion of perpendicular foot, we prove the existence of the midpoint (Satz 8.22), which will be used in the form of the Mizar functor (as the uniqueness can be easily shown) in Chapter 10. In the last section we give some lemmas proven by means of Otter during Tarski Formalization Project by M. Beeson (the so-called Section 8A of SST).

Summary The real projective plane has been formalized in Isabelle/HOL by Timothy Makarios [13] and in Coq by Nicolas Magaud, Julien Narboux and Pascal Schreck [12]. Some definitions on the real projective spaces were introduced early in the Mizar Mathematical Library by Wojciech Leonczuk [9], Krzysztof Prazmowski [10] and by Wojciech Skaba [18]. In this article, we check with the Mizar system [4], some properties on the determinants and the Grassmann-Plücker relation in rank 3 [2], [1], [7], [16], [17]. Then we show that the projective space induced (in the sense defined in [9]) by ℝ3 is a projective plane (in the sense defined in [10]). Finally, in the real projective plane, we define the homography induced by a 3-by-3 invertible matrix and we show that the images of 3 collinear points are themselves collinear.

Abstract In this article, using mostly Pervin [9], Kunzi [6], [8], [7], Williams [11] and Bourbaki [3] works, we formalize in Mizar [2] the notions of quasiuniform space, semi-uniform space and locally uniform space. We define the topology induced by a quasi-uniform space. Finally we formalize from the sets of the form ((X \ Ω) × X) ∪ (X × Ω), the Csaszar-Pervin quasi-uniform space induced by a topological space.

Summary We formalize, in two different ways, that “the n-dimensional Euclidean metric space is a complete metric space” (version 1. with the results obtained in [13], [26], [25] and version 2., the results obtained in [13], [14], (registrations) [24]). With the Cantor’s theorem - in complete metric space (proof by Karol Pąk in [22]), we formalize “The Nested Intervals Theorem in 1-dimensional Euclidean metric space”. Pierre Cousin’s proof in 1892 [18] the lemma, published in 1895 [9] states that: “Soit, sur le plan YOX, une aire connexe S limitée par un contour fermé simple ou complexe; on suppose qu’à chaque point de S ou de son périmètre correspond un cercle, de rayon non nul, ayant ce point pour centre : il est alors toujours possible de subdiviser S en régions, en nombre fini et assez petites pour que chacune d’elles soit complétement intérieure au cercle correspondant à un point convenablement choisi dans S ou sur son périmètre.” (In the plane YOX let S be a connected area bounded by a closed contour, simple or complex; one supposes that at each point of S or its perimeter there is a circle, of non-zero radius, having this point as its centre; it is then always possible to subdivide S into regions, finite in number and sufficiently small for each one of them to be entirely inside a circle corresponding to a suitably chosen point in S or on its perimeter) [23]. Cousin’s Lemma, used in Henstock and Kurzweil integral [29] (generalized Riemann integral), state that: “for any gauge δ, there exists at least one δ-fine tagged partition”. In the last section, we formalize this theorem. We use the suggestions given to the Cousin’s Theorem p.11 in [5] and with notations: [4], [29], [19], [28] and [12].

Abstract We are inspired by the work of Henri Cartan [16], Bourbaki [10] (TG. I Filtres) and Claude Wagschal [34]. We define the base of filter, image filter, convergent filter bases, limit filter and the filter base of tails (fr: filtre des sections).

Abstract Morley’s trisector theorem states that “The points of intersection of the adjacent trisectors of the angles of any triangle are the vertices of an equilateral triangle” [10]. There are many proofs of Morley’s trisector theorem [12, 16, 9, 13, 8, 20, 3, 18]. We follow the proof given by A. Letac in [15].