Dynamic Boosting Systems (United Kingdom)

<p>This thesis constitutes a proposal for the exhibition, Esson’s Ontario: Celebrating James Esson’s Stereographic Tour of Ontario, which will be mounted in 2013 at the Archives of Ontario in their Reading Room display cases. Using the collection of 40 James Esson stereographs at the Archives of Ontario, the proposed exhibition will re-introduce Esson and his stereographs of the province of Ontario. A curatorial statement and a concept for the design of the exhibition will follow and introduction to James Esson and his life and work as a photographer and stereographer, and some of the assets and difficulties of displaying works in the Reading Room display cases will be addressed. The thesis includes appendices that outline the design of the exhibition, including the English panel texts, exhibition designs and checklists.</p>

Recent evidence suggests that patient derived xenograft (PDX) models can maintain certain pathological and molecular features of the original disease. However, these characterizations are limited to immunohistochemistry or by tissue microarray analysis. We conducted a high-throughput sequencing of primary colon tumor and PDX has not been reported yet.Fresh primary colon cancer tissues that originate from surgery were implanted into the subcutaneous space of 6- to 8-week-old female BALB/c nu/nu or NOD/SCID mice and serially passaged in vivo. Ion AmpliSeq Cancer Hotspot Panel v2 (Ion Torrent) was used to detect frequent somatic mutations and similarity of molecular characteristics between the 10 patient tumors and matched PDX.Histologic and immunohistochemical analyses revealed a high degree of pathologic similarity including histologic architecture and expression of CEA, CK7, and CD20 between the patient and xenograft tumors. In 80% cases, all of the somatic mutations detected in primary tumor were concordantly detected in PDX models. However, 2 PDX models showed gained mutations such as PIK3CA or FBWX7 mutation.Ten patient-derived advanced colon cancer xenograft models were established. These models maintained the key characteristic features of the original tumors, suggesting useful tool for preclinical personalized medicine platform.

Exchange Traded Products (ETPs) are garnering massive interest around the world, and continue to capture a greater portion of fund inflows. ETPs have now garnered over $2 trillion in assets globally, across a variety of asset classes and strategies. Though initially passive, ETPs are now also “active,” both in the strategies/indexes they employ and in terms of their usage, with some ETPs trading their entire Assets Under Management (AUM) on a single day. Much of recent ETP innovation has been focused on alternative indexes, which include smart beta and “alpha”-styles indexes. These indexes seek to generate superior risk-adjusted returns compared to standard market capitalisation-weighted indexes, or offer low correlation to traditional market indexes. As new entrants continue to innovate, ETPs will continue to target niche areas, such as new geographies, asset classes, portfolio-indexes, active ETPs, and more strategic research-led indexes. The result is that indexes associated with more tactical or active investing will find their way into ETP-format, and that the lines between passive and active may appear blurred.

This paper reports about our investigation on action understanding in the brain. We review recent results of the neurophysiology of the mirror system in the monkey. Based on these observations we propose a model of this brain system which is responsible for action recognition. The link between object affordances and action understanding is considered. To support our hypothesis we describe two experiments where some aspects of the model have been implemented. In the first experiment an action recognition system is trained by using data recorded from human movements. In the second experiment, the model is partially implemented on a humanoid robot which learns to mimic simple actions performed by a human subject on different objects. These experiments show that motor information can have a significant role in action interpretation and that a mirror-like representation can be developed autonomously as a result of the interaction between an individual and the environment.

EDITOR, - I support Allen Hutchinson's statement that key elements in the variation in rates of referral to hospital are the behaviour of individual doctors, and the factors underlying this.1 Some years ago I suggested that there were four main reasons for referral to a psychiatric clinic.2 I have found from experience since that these reasons also apply, in varying degrees, to other specialties, particularly gastroenterology. …

ABSTRACT This paper is one of two describing changes to the IADC Classification and Dull Grading Systems for fixed cutter bits. Dull grading system revisions, described herein, were implemented to improve utilization and effectiveness of the dull grading system. Classification system changes were required as a result of improvements in bit technology and applications, and are detailed in the companion paper SPE 23940.