Edelman (United Kingdom)

This Article describes and analyzes major developments in insurance law that occurred in Texas between December 1 and November 30 of 2022.

Background: Platelets are a major culprit in the pathogenesis of cardiovascular disease (CVD). Although vascular disease in different arterial beds share common risk factors, the role of platelet activity may differ by vascular bed. Clinical trials suggest that more potent antiplatelet therapy is needed in lower extremity peripheral artery disease (PAD) than coronary artery disease (CAD). We investigated circulating monocyte platelet aggregates (MPA), a reproducible ex vivo measurement of platelet activity, in patients with CVD (PAD, CAD, carotid artery stenosis [CAS], and abdominal aortic aneurysm [AAA]) and disease controls. Methods: Subjects with CVD (n=351) and disease controls (n=73) had MPA measured using strict quality control, all of whom were on aspirin monotherapy. MPA were identified by CD14/CD61 positivity. Data is represented as median (IQR, interquartile range). Wilcoxon rank sum, Wilcoxon signed rank, and multivariable linear regression were used to analyze data. Results: Platelets aggregated with monocytes had a higher platelet surface expression of PAC-1, P-selectin, and CD40 versus platelets not aggregated with monocytes (P<0.05 for each comparison). Compared with controls, MPA was significantly higher in CVD (14.5 [10.3, 27.8] vs. 9.4 [8.2, 11.5], P<0.001) which remained significant after multivariable adjustment for demographics and risk factors (β=9.1 (SER=3.9), P=0.02). For each vascular disease phenotype, MPA was higher than controls ( Figure ). In a multivariable linear regression model including demographics, risk factors and each vascular bed, PAD was the only vascular disease associated with a higher value of MPA (β=10.2 (SER=2.4), P<0.001). Conclusions: Platelets aggregated with monocytes have increased platelet activity and are significantly elevated in subjects with PAD. Future studies understanding the platelet profile in PAD and its clinical relevance are needed.

All objects radiate infrared energy invisible to the human eye, which can be imaged by infrared cameras, visualizing differences in temperature and/or emissivity of objects. Infrared imaging is an emerging technique for forensic investigators. The rapid, nondestructive, and noncontact features of infrared imaging indicate its suitability for many forensic applications, ranging from the estimation of time of death to the detection of blood stains on dark backgrounds. This paper provides an overview of the principles and instrumentation involved in infrared imaging. Difficulties concerning the image interpretation due to different radiation sources and different emissivity values within a scene are addressed. Finally, reported forensic applications are reviewed and supported by practical illustrations. When introduced in forensic casework, infrared imaging can help investigators to detect, to visualize, and to identify useful evidence nondestructively.

Henry Greely hails a study examining California's experience of mandatory newborn genetic screening.

Journal of Public AffairsVolume 12, Issue 1 p. 74-76 Practitioner Paper A decade of change and continuity in public affairs Michael Burrell, Corresponding Author Michael Burrell michael.burrell@mail.com European Centre for Public Affairs, Middlesex, UK Edelman, London, UK Michael Burrell, European Centre for Public Affairs, Kingston Lane, Uxbridge, Middlesex, UB8 3PH, UK. E-mail: michael.burrell@mail.comSearch for more papers by this author Michael Burrell, Corresponding Author Michael Burrell michael.burrell@mail.com European Centre for Public Affairs, Middlesex, UK Edelman, London, UK Michael Burrell, European Centre for Public Affairs, Kingston Lane, Uxbridge, Middlesex, UB8 3PH, UK. E-mail: michael.burrell@mail.comSearch for more papers by this author First published: 22 July 2011 https://doi.org/10.1002/pa.406Citations: 3Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article.Citing Literature Volume12, Issue1Special Issue: 12th Anniversary Issue on Public Affairs–Retrospective and Future DevelopmentFebruary 2012Pages 74-76 RelatedInformation

Abstract: Measured atrazine concentrations in Nebraska surface water have been shown to exceed water‐quality standards, posing risks to humans and to the ecosystem. To assess this risk, atrazine runoff was simulated at the field‐scale in Nebraska based on the pesticide component of the AGNPS model. This project’s objective was to determine the frequency that the atrazine concentration at the field outlet exceeded three different atrazine water‐quality criteria. The simulation was conducted for different farm management practices, soil moisture conditions, and five Nebraska topographic regions. If the criteria were exceeded, a risk to the drinking water consumer or freshwater aquatic life was hypothesized to exist. Three pesticide fate and transport processes were simulated with the model. Degradation was simulated using first‐order kinetics. Adsorption/desorption was modeled assuming a linear soil‐water partitioning coefficient. Advection (runoff) was based primarily on the USDA‐NRCS curve number method. Daily rainfall from the National Weather Service was used to compute the soil moisture conditions for the 1985‐2000 growing seasons. After each runoff event, the pesticide runoff concentration was compared with each of the three atrazine water‐quality criteria. The results show that environmental receptors (i.e., freshwater aquatic species) are exposed to unacceptable atrazine runoff concentrations in 20‐50% of the runoff events.