Emam Reza Hospital

Primary cardiac tumors exhibit a very low incidence, estimated between 0.001% and 0.03%. Among these, malignancies constitute a minority (∼25%), with sarcomas representing the vast majority (~95%) of such cases. Cardiac intimal sarcoma is among the rarest subtypes of primary cardiac sarcoma. This category of endocardial-based mesenchymal tumor typically originates in the great arteries and only infrequently develops within the heart itself. Their clinical behavior is notably aggressive, leading to a generally poor prognosis; consequently, the cornerstone of management is complete surgical excision with negative margins. This highlights the critical need for precise and early diagnosis to facilitate prompt intervention. This report details the case of a 20-year-old man with a prior history of Ewing sarcoma located in the left atrium, for which he had undergone previous cardiac surgery. In preparation for a subsequent procedure, hybrid imaging through 18 F-FDG PET/CT was utilized to characterize intracardiac masses, quantify tumor burden, and exclude the possibility of a new, extracardiac primary malignancy. Collectively, though drawn from limited case series and the present illustrative case, existing literature indicates that PET imaging provides supplemental diagnostic value beyond stand-alone CT or MRI. It enhances the evaluation of cardiac masses in both preoperative and posttherapeutic contexts. This integrated approach improves the determination of surgical candidacy and allows for the early detection of local or distant disease recurrence, which are pivotal components for structuring effective overall treatment strategies.

There are still not many academic reports on cases where privately owned postwar modern architecture that are not registered as cultural properties and have been completely renovated. In order to preserve and maintain more modern architecture in the future, it is essential not only to discuss methodologies, but also to accumulate reports of similar cases that can be referred to. This paper reports the overview of the Office and Hall of All Japan Seamen’s Union designed by Masato Otaka and completed in 1964, and its process toward the decision making of the renovation project.

Pendahuluan: Low back pain merupakan masalah kesehatan yang sering dialami oleh lansia dan berdampak pada penurunan kemampuan fungsional serta kualitas hidup. Penggunaan analgesik jangka panjang berisiko menimbulkan efek samping, sehingga diperlukan alternatif terapi nonfarmakologi yang aman dan mudah diterapkan. Salah satu intervensi yang dapat digunakan adalah kompres jahe hangat yang memiliki efek antiinflamasi dan analgesik alami. Tujuan: Penelitian ini bertujuan untuk mengetahui pengaruh kompres jahe hangat terhadap penurunan nyeri low back pain pada lansia di Kelurahan Tondo. Metode: Penelitian ini menggunakan desain quasi-eksperimental dengan pendekatan pre and post control group. Populasi berjumlah 60 lansia, dan sampel berjumlah 38 lansia yang mengalami dan dipilih menggunakan teknik purposive sampling. Kelompok perlakuan diberikan intervensi kompres jahe hangat selama lima hari berturut-turut dengan durasi 15 menit, sedangkan kelompok kontrol tidak diberikan intervensi. Tingkat nyeri diukur menggunakan Numeric Rating Scale (NRS). Analisis data dilakukan menggunakan uji Wilcoxon dan Mann-Whitney. Hasil: Hasil penelitian menunjukkan adanya penurunan tingkat nyeri yang signifikan pada kelompok perlakuan setelah diberikan kompres jahe hangat (p < 0,05). Tidak ditemukan perbedaan signifikan pada kelompok kontrol. Uji perbandingan antar kelompok menunjukkan perbedaan bermakna setelah intervensi. Kesimpulan: Kompres jahe hangat efektif menurunkan nyeri pada lansia dan dapat digunakan sebagai terapi nonfarmakologi dalam praktik keperawatan komunitas. Kata kunci : Kompres jahe hangat, Lansia,

BackgroundBiologics and Janus kinase (JAK) inhibitors have expanded treatment options for moderate-to-severe atopic dermatitis (AD), but comparative real-world data remain limited.ObjectiveThis study aims to compare disease-related characteristics and outcomes of patients with moderate-to-severe AD treated with biologics or JAK inhibitors (JAKi) in routine clinical practice.Materials and methodsAn ambispective, observational study was conducted across three hospitals in southern Spain. Patients who initiated advanced systemic therapy (AST) between 2019 and 2024 were included in the study. Baseline disease-related variables, clinical severity scores, treatment outcomes, adverse events, and drug survival were assessed. Short-term (16 weeks) and medium-to-long-term (24 and 52 weeks) intervals were considered. Super-responder rates, based on a proposed definition, were also evaluated.ResultsA total of 202 patients were included (134 treated with biologics and 68 with JAK inhibitors). JAK inhibitors produced faster early responses, while biologics achieved greater absolute improvements between weeks 16 and 52, along with longer treatment persistence. The adverse event profiles differed between the drug classes: infections and acne were more common with JAKi, while ocular symptoms were more common with biologics. The difference in super-responder rates between groups was not statistically significant (16.42% vs. 23.53%, p = 0.25443).ConclusionBoth treatment classes were effective and well-tolerated. Differences in response dynamics and safety profiles support individualized treatment decisions.

Abstract AIMS Solitary fibrous tumours (SFTs) are rare malignant mesenchymal neoplasms within the central nervous system (CNS). Although achieving surgical gross total resection (GTR) is a pivotal prognostic factor, the role and efficacy of postoperative radiotherapy (PORT) remain contentious. This study elucidates our institutional experience, placing particular emphasis on outcomes after PORT administration. METHODS Fourteen patients with CNS SFTs were studied through retrospective review of clinical presentation, radiologic findings, histopathologic characteristics, surgical intervention, adjuvant therapy, and prognosis. Kaplan-Meier survival analysis evaluated overall survival (OS) and recurrence-free survival (RFS) based on the world health organization (WHO) grade, extent of resection (EOR), and application of PORT. RESULTS The cohort included 8 men and 6 women. Magnetic resonance imaging (MRI) revealed slightly hyperintense lesions on T2-weighted images in all patients. All tumours showed positive immunohistochemical staining for signal transducer and activator of transcription 6. WHO grade III tumours had higher Ki-67 indices, stronger CD34 and BCL-2 staining, and more frequent RF positivity compared to WHO grade II tumours. Although grade III tumours exhibited poorer OS than grade II tumours, this was not statistically significant (p = 0.26). RFS was also not significantly different between grades II and III (p = 0.75), though grade III tumours showed earlier recurrences. GTR significantly improved OS compared to subtotal resection (STR) (p = 0.011), with STR patients experiencing a steeper decline in survival. While no significant difference in RFS was noted between GTR and STR (p = 0.45), STR was associated with earlier recurrences. Receiving PORT did not significantly improve OS (p= 0.19) or RFS (p = 0.45) compared to not receiving it. CONCLUSION Achieving complete tumour resection should be prioritised whenever feasible, with adjuvant radiotherapy ad- vised following surgical excision. Additionally, regular and long-term follow-up is imperative to monitor for potential recurrence.

Fertility preservation is a critical aspect of improving human life quality. Sperm cryopreservation is highly recommended for men at risk of infertility; however, it can have detrimental effects on sperm quality. In this study, we evaluate the effects of platelet-rich plasma (PRP) and PRP-derived exosomes on cryopreservation outcomes in men with asthenoteratozoospermia referred to a public infertility center. The semen samples from 75 men with asthenoteratozoospermia (based on WHO 2020 criteria) were randomly divided into five groups: Control (conventional freezing), Exo/before, Exo/After, PRP/Before, and PRP/After. In all intervention groups, PRP or exosomes were added either 1 h before freezing or 1 h after thawing. Sperm parameters and oxidative stress were evaluated in all samples. Sperm incubation with exosomes before freezing significantly improves motility and lowers DNA fragmentation index (DFI) and oxidative stress compared to the control and other groups. Based on the present study, semen incubation with exosomes for 1 h before freezing not only protects sperm against oxidative stress but also enhances some sperm parameters, such as motility, in men with asthenoteratozoospermia.

In 2023, the VAS international working group on Buerger's Disease (BD) recommended two diagnostic criteria based on a prior Delphi study: "definitive" and "suspected". The "definitive" criteria are history of smoking, typical angiography, and typical histopathological features. All three features are mandatory to confirm a "definitive" diagnosis of BD. The conundrum is-what features should be considered typical of BD angiography? According to this review, segmental occlusion of infrapopliteal arteries, corkscrew collaterals that appear to continue the occluded arterial segment (Martorell's sign) or bypass the segmental occlusion, absence of atherosclerotic plaque or aneurysm could differentiate BD from ASO. Hence, for "typical" BD angiography, these manifestations should certainly be considered. However, data for differentiating angiography patterns of BD from the small- and medium-sized vasculitis including Behcet's disease, scleroderma, hepatitis associated vasculitis, and anti-phospholipid syndrome are limited. Further studies for investigating the angiography pattern in BD patients in early and late presentation of BD, particularly in the patients with long-term follow up, are highly recommended.