Evotec (United States)

Clinical research is a strategic priority for the Italian healthcare system, with significant benefits for patients, economy and public health. The Clinical Advancement & Research Excellence (CARE) project identified the main obstacles that limit the full expression of the potential of clinical trials in Italy and proposed concrete solutions. Starting with an online survey and following a simplified Delphi method, a multidisciplinary panel of experts identified the main barriers to clinical research in Italy and proposed a set of programmatic instances designed to improve the present situation. The final instances were formulated also based on the review by external stakeholders. The following programmatic instances were developed: 1) support the compliance with trial contract signing times; 2) create a national standard for Clinical Trial Sites (CTS) and a dedicated portal; 3) define the role of General Practitioners; 4) promote campaigns to raise awareness on the importance of clinical research. The instances presented offer concrete insights to optimize the effectiveness and efficiency of clinical trials in Italy, ensuring international competitiveness and allowing patients to benefit from innovative therapies.

Phase-change materials (PCMs) integrated into multi-pane windows can reduce building energy consumption and improve thermal comfort by increasing energy storage capacity. In this study, three window configurations with PCMs (TGP-1, TGP-2, and TGP-3) were thermally evaluated and compared with a conventional triple-pane (TG) window. The evaluation was performed for each season’s warmest and coldest days, which were selected based on the ambient temperature. A numerical code was developed in C + + based on the finite volume method to model the transient heat transfer in windows. For the modeling, we used meteorological variables (solar radiation, ambient temperature, and wind velocity) of Mérida, Yucatán, for the boundary conditions. We found that the TGP-3 reduced heat fluxes through it by up to 37.4 % regarding TG on the warmest day of spring. Furthermore, the annual electricity consumption cost and CO 2 emissions obtained by the TGP-3 (27.9 USD/m 2 and 281.2 kgCO 2 e/m 2 ) were 7.1 % lower than those of TG. Furthermore, the TGP-3 exhibited satisfactory dynamic thermal performance in the spring and summer; therefore, it is recommended to be used in these seasons. And for autumn and winter seasons, it is proposed to combine this configuration with technologies that reduce direct solar radiation. • Unsteady heat transfer in a triple glazing window (TG) with PCM, TGP-3, was modeled. • TGP-3 decreases the surface temperature up to 2.5 °C compared to TG on the spring day. • TGP-3 reduces the indoor heat flux on the spring day by 37.4 % compared to the TG. • TGP-3 reduces the CO 2 emission up to 7.1 % compared to one without PCM. • TGP-3 presents high values of time lag on both spring and summer seasons.

La mosca negra del higo (Silba adipata McAlpine, 1956) es una de las principales plagas que afecta la producción de higo (Ficus carica L.) en México, provocando pérdidas de hasta 88 %. El control químico ha mostrado eficacia limitada para controlar la plaga; una alternativa para disminuir suincidencia es mediante la colocación de trampas con atrayentes. En este contexto, el objetivo del presente estudio fue evaluar posibles atrayentes para la mosca negra del higo en condiciones de laboratorio. Se evaluaron tres diseños estructurales, se identificó que los diseños estructurales I y II, compuestos por cubos de acetato interconectados con dimensiones distintas fueron adecuados para la evaluación de atrayentes. Finalmente se evaluaron seis extractos crudos (hexánico, metanólico y acuoso), obtenidos a partir de frutos de higo y manzana, además de un tratamiento testigo (sulfato de amonio y manzana), colocados en trampas con atrayente. El potencial atrayente se evaluó a partir del número de moscas capturadas. El testigo presentó mayor efectividad, con el 28.20 % de moscas capturadas en el diseño estructural II y el 29.59 % en el diseño estructural I, seguido del extracto metanólico de manzana, con el 23.17 % en el diseño estructural II y el 26.10 % en el diseño estructural I. El extracto acuoso de higo obtuvo el 20.46 % el diseño estructural I y el 23.17 % en el diseño estructural II, siendo el tercer atrayente más efectivo. En contraste, tanto el extracto hexánico de higo como el extracto acuoso de manzana fueron los atrayentes menos efectivos con el 0 % de capturas.

The mononuclear phagocyte system (MPS) is an ensemble of heterogeneous cells comprising circulating monocytes, macrophages, and dendritic cells. Immunohistochemistry is a valuable technique to detect, quantify, and localize MPS cells in tissues, but a comprehensive characterization of MPS cells in normal tissues of mice is lacking to date. The aim of this study was to immunohistochemically characterize MPS cells in a set of murine healthy tissues and in a subset of representative disease states. Sections of healthy tissues obtained from 21 C57BL/6J and C57BL/6N mice and sections of inflammatory (necrosuppurative hepatitis and Pneumocystis murina-associated pneumonia) and experimentally induced neoplastic conditions (human fibrosarcoma xenograft and mammary carcinoma syngraft) were immunolabeled with a panel of MPS markers, including IBA1, F4/80, macrophage receptor with collagenous structure (MARCO), CD206, arginase 1, Ym1, induced nitric oxide synthase, heme-oxygenase 1 (HO-1), and class II major histocompatibility complex (MHC-II). For each tissue, the amount, morphology, location, and immunolabeling intensity of positive cells were evaluated using semi-quantitative scores. Results highlighted the morphological and immunophenotypic heterogeneity of murine MPS cells. The panel of antibodies used allowed for discrimination of different cell populations across the examined tissues based on immunophenotype, microanatomical location, and morphology, providing useful morphological and functional clues on MPS cells in both physiological and diseased conditions. The results of this study provide a valuable reference regarding the amount, morphology, microanatomical location, and immunophenotype of MPS subsets in healthy murine tissues. In addition, it highlights the plasticity of these cells in inflammatory and neoplastic settings, underscoring the importance of a comprehensive characterization of MPS cells in physiological and disease states.

Pelayanan kefarmasian di apotek merupakan pelayanan yang bertanggungjawab kepada setiap pelanggan yang melakukan transaksi di apotek dengan tujuan untuk meningkatkan kualitas kesehatan pasien. Pelayanan kefarmasian yang berkualitas berpotensi memotivasi keputusan pembelian di Apotek. Penelitian ini bertujuan untuk dapat melihat hubungan tingkat kualitas pelayanan kefarmasian dengan keputusan pembelian pelanggan di Apotek Askia Bogor. Penelitian ini merupakan penelitian deskriptif kuantitatif dengan memberikan kuesioner kepada 99 sampel menggunakan teknik purposive sampling dalam pengambilan datanya. Data dianalisis dengan uji korelasi Somers’d. Data hasil uji Somers’d menunjukkan nilai p-value 0,017<0,05 yang mengindikasikan terdapat hubungan signifikan antara tingkat kualitas pelayanan kefarmasian dengan keputusan pembelian pelanggan di Apotek Askia Bogor. Nilai koefisiensi Somers’d sebesar 0,249 mendeskripsikan keeratan hubungan yang rendah dan searah.

Populasi penduduk Indonesia sebagian besar adalah umat beragama Islam. Maka dari itu diketahui bahwa seluruh produk terutama obat-obatan di Indonesia harus memiliki sertifikasi halal dari MUI. Fitofarmaka merupakan salah satu obat tradisional yang telah disarankan oleh dokter, Fitofarmaka juga telah melalui uji praklinik dan uji klinik. Saat ini obat jenis Fitofarmaka telah banyak diminati oleh para konsumen. Penelitian ini bertujuan untuk mengetahui minat beli konsumen terkait ada atau tidaknya label halal pada obat jenis Fitofarmaka. Metode penelitian yang digunakan yaitu metode survei eksplanatori. Metode ini bersifat kuantitatif dan digunakan untuk menguji perilaku individu atau kelompok dengan mengambil sampel dari populasi dan menggunakan kuesioner sebagai alat pengumpulan data. Hasil penelitian menunjukkan bahwa diketahui korelasi antar kedua variabel label halal dan minat beli yaitu memiliki korelasi lemah, artinya tidak terdapat pengaruh yang signifikan pada label halal dalam mempengaruhi minat beli konsumen pada produk obat Fitofarmaka. Hal ini diketahui dari diperolehnya nilai koefisien determinasi sebesar 0,394 (korelasi lemah). Maka kesimpulan dalan ini adalah diketahui bahwa ada atau tidak adanya label halal dalam produk obat Fitofarmaka tidak mempengaruhi secara signifikan terhadap minat beli konsumen di Apotek Cangkiran.

Acknowledging the importance of implementing environmental policies at the ground level, research reveals slow knowledge diffusion and behavioral challenges affecting policy outcomes. Despite the global consensus, national sustainable development policies often remain incomplete. Focusing on education, while the circular economy (CE) is extensively discussed in higher education, it remains notably absent in primary education curriculums. Drawing on the responses of 61 primary education teachers, this study (i) locates the lack of integration of circularity and sustainability concepts at Greek State primary schools, underscores the necessity for their inclusion into the curriculum more systemically and systematically to address disparities, and suggests solutions for a more comprehensive environmental education; (ii) unveils primary educators’ awareness and positivity toward teaching-learning of sustainable development goals and education for a CE and emphasizes on their ongoing support, education, and training.