Faculdade Meridional

This study explores how equity financing supports entrepreneurial ventures' development and expansion stages. By reviewing the existing literature, this study looks into how equity finance influences business development as companies progress through different stages of entrepreneurship. The findings reveal equity financing as an important catalyst, offering both crucial capital and strategic support to scale operations effectively. Although many studies support a strong relationship between equity finance and business growth, issues such as ownership dilution and potential stakeholder conflicts are highlighted. By integrating key findings from previous research, this study strengthens the understanding of how equity financing affects entrepreneurial success. The conclusion offers valuable implications for entrepreneurs, investors, and policymakers, underlining the need for strategic financial planning to sustain long-term growth and innovation across the entrepreneurial ecosystem.

Purpose: This study aims to identify an effective strategy for Indonesia to counter China's gray zone tactics in the South China Sea. Theoretical Reference: Employing a quantitative method with a descriptive approach rooted in the positivist philosophy, this research follows the principles outlined by Sugiyono (2011). This method is chosen for investigating specific populations or samples, with a focus on quantitative/statistical data analysis to test predetermined hypotheses. Method: The research employs multiple regression analysis to assess the significance of Soft Power Diplomacy and Smart Power Diplomacy strategies as essential national resources for persuading China to undertake desired actions in addressing the challenges posed by China's Gray Zone in the South China Sea. Smart power, as defined by Jr J.N. (2007), involves integrating soft and hard power for a comprehensive strategy. According to R. Wilson (2008), smart power effectiveness lies in combining a robust military force with investments in alliances, partnerships, and cooperation. Result and Conclusion: The findings indicate that both Soft Power Diplomacy and Smart Power Diplomacy are influential tools and strategies within Indonesia's foreign policy context to effectively navigate and counteract China's Gray Zone activities in the South China Sea. Implications of Research: The identified strategies hold significant implications for shaping Indonesia's defense diplomacy against China's gray zone tactics, emphasizing the importance of integrating soft and hard power elements for a more comprehensive and efficient approach. Originality/Value: This research contributes to the field by highlighting the relevance and effectiveness of Soft Power Diplomacy and Smart Power Diplomacy as key components in Indonesia's defense diplomacy strategy, providing a nuanced understanding of countering China's Gray Zone activities in the South China Sea.

bucais embutidas na cabeça, dentro da cavidade bucal), possuem um par de antenas, três pares de pernas torácicas e apêndices abdominais: o colóforo (ou tubo ventral) utilizado na absorção de água, gases e fixação do animal ao substrato (solo ou película d'água), o tenáculo que sustenta a furca sob o abdome, e a furca estrutura usada para saltar, formada por um manúbrio único e um par de dentes terminando em um

Neste estudo, parte-se de discussões entre corpo, sexualidade e religião. A pergunta que se apresenta é: como a teologia legitima abusos contra corpos, especialmente os femininos? Para tanto, mesclam-se análise e interpretação, procedimentalmente a pesquisa é bibliográfica e qualitativa. O objetivo do estudo é entender o corpo na religião cristã historicamente até os nossos dias. Ademais, apresenta-se um caso brasileiro com reflexos internacionais: João de Deus, que já fora condenado pelo Poder Judiciário por crimes sexuais contra fiéis que procuravam seus trabalhos espirituais. Faz-se análise de (re)leituras do corpo e do sexo na teologia a partir da teologia inclusiva, queer ou indecente, que integra a sexualidade de Deus, dos crentes e a libertação das atividades religiosas machistas e tradicionais. Para tanto, utilizam-se os estudos da teóloga argentina Marcella Althaus-Reid

The satisfaction of members is a central issue in a cooperative, as they are the ones who carry out development actions. Thus, this work aimed to analyze the satisfaction of the cooperative members of Cooperativa X de Santa Maria. For this, a descriptive and exploratory research was carried out, considered a case study of a quantitative nature. Satisfaction was analyzed using the Job Satisfaction Scale, developed by Siqueira (2008) where five categories were evaluated. Regarding satisfaction with colleagues and satisfaction with leadership, the cooperative members were satisfied, however, around 15% of the cooperative members are dissatisfied with this requirement. With regard to satisfaction with the salary, the highest rates of dissatisfaction occurred, in some of the questions dissatisfaction was paramount, regarding satisfaction with the nature of the work and satisfaction with promotions, the highest rates were those of satisfaction, but the study showed a strong indifference, which indicates a certain detachment with the future of the organization. It is concluded that salary reassessments are necessary, to encourage cooperativism and cooperative education, above all the cooperative must listen more to its member, being able to be an active voice representing its member if necessary.

Neonatal diabetes mellitus (NDM) is defined as the occurrence of severe hyperglycemia in infants under 6 months old and may be permanent (PNDM) or transient (TNDM). When diabetes is diagnosed at 6-12months of age (early onset diabetes [EOD]), the etiology may be monogenic; however, most cases consist of type 1 diabetes mellitus (T1DM). Molecular diagnosis was determined in a cohort of 35 unrelated Brazilian patients with NDM or EOD based on targeted next-generation sequencing panel and/or chromosome 6q24 abnormalities. The impact of genetic testing on treatment and follow-up was evaluated. Overall, 24 patients had NDM: with 18 (75.0%) having PNDM, 5 TNDM (20.8%) and 1 case in which this information was unknown. Eleven patients had EOD. Genetic testing was positive in 20/24 patients with NDM (83.3%) and in 18.2% of cases of EOD. The commonest causes were ATP-sensitive potassium (KATP) channel genes, and GCK and IPEX mutations (37.1%, 11.4% and 5.7%, respectively). Patients with PNDM due to KCNJ11 and ABCC8 mutations transitioned successfully to sulfonylureas in almost 60% of cases, reinforcing the benefit of performing genetic testing in NDM as early as possible. This report refers to the largest series of cases of NDM (TNDM and PNDM) and EOD in Brazil in which patients were submitted to molecular investigation and in which the clinical impact of genetic diagnosis was also evaluated.

O presente trabalho teve como objetivo principal analisar a evolução dos indicadores sociais dos municípios do Agreste Meridional, no intuito de identificar a influência da implantação da Universidade Federal do Agreste de Pernambuco na região. Especialmente buscou-se observar os efeitos sociais da implantação da UFAPE, para o município de Garanhuns, onde está sediada, bem como para os demais municípios do Agreste Meridional, buscando avaliar a progressão desses efeitos para o desenvolvimento social da região como um todo. Para isso, além do Índice de Desenvolvimento Humano - IDH, também foram analisados os indicadores de Educação dos municípios do Agreste Meridional como os índices Firjam de Desenvolvimento Municipal – IFDM-Educação, que avalia o grau de desenvolvimento da educação dos municípios brasileiros, e o percentual de docentes com formação superior, no intuito de observar a melhoria do capital humano atuante nas escolas da região. Assim, apoiando-se em literatura pertinente e nos indicadores expostos, foi possível apontar para as influências da UFAPE nas transformações da dinâmica social dos municípios do Agreste Meridional.

Salmonellosis is one of the most common foodborne diseases worldwide. Surface adherence and biofilm formation are among the main strategies evolved by Salmonella to survive under harsh conditions and are risk factors for its spread through the food chain. Owing to the increase in antimicrobial resistance, there is a growing need to develop other methods to control foodborne pathogens, and bacteriophages have been suggested as a potential alternative for this purpose. The aim of this study was to evaluate bacteriophages as a biological control of Salmonella enterica serotypes to inhibit and remove bacterial biofilms. A total of 12 S. enterica isolates were selected for this study, all of which were biofilm producers. Seven bacteriophages were tested, individually and in a cocktail, for their host range and efficiency of plating (EOP). The phage cocktail was evaluated for its antibiofilm effect against the Salmonella biofilms. Phages UPF_BP1, UPF_BP2, UPF_BP3, UPF_BP6, and 10:2 possessed a broad lytic spectrum and could infect all S. enterica strains. Phages 10:2, UPF_BP6, and UPF_BP3 had high EOP in 10, 9, and 9 out of the 12 S. enterica strains, respectively. The cocktail was able to infect all S. enterica strains and had a high EOP in 10 out of 12 S. enterica isolates, presenting a broader host range than any of the tested single phages. A wide variation of inhibition among strains was observed, ranging from 14.72% to 88.53%. Multidrug-resistant and strong biofilm producer strains showed high biofilm inhibition levels by phage cocktail. Our findings demonstrate the ability of the cocktail to prevent biofilm formation and remove formed biofilms of Salmonella. These results indicate that the phage cocktail is a promising candidate to be used as an alternative for the control of Salmonella biofilms through surface conditioning.

No presente artigo, pretende-se estabelecer os elementos teórico-dogmáticos das normas de referência a serem editadas pela Agência Nacional de Águas e Saneamento Básico (ANA) no setor, a partir da disciplina jurídica oriunda da recente Lei nº 14.026/2020. Tal legislação estruturou o novo marco legal do saneamento básico no Brasil. Abordou-se, primeiramente, como se desenvolve a regulação no setor de saneamento básico, destacando-se a complexidade que tal âmbito jurídico impõe, seja pela multiplicidade de atos normativos, seja pela especificidade técnica, seja pelos múltiplos atores que ali se inserem. Objetivamente, pretende-se, neste artigo, demonstrar que o setor contará com uma série de regulações oriundas de agentes diversos, todas elas amparadas em uma regulação de referência de natureza nacional, a ser editada por agência reguladora federal. Como este panorama é inédito no Brasil, optou-se por estruturar a pesquisa por meio do método de abordagem dedutivo e exploratório, conformando o detalhamento do tema a partir de precisões dogmáticas, para se conseguir analisar as causas da regulação do saneamento básico e se demonstrar qual é a natureza das “normas de referência”, seu alcance e sua finalidade.

BackgroundContinuous measurement of urinary PO2 (PuO2) is being applied to indirectly monitor renal medullary PO2. However, when applied to critically ill patients with shock, its measurement may be affected by changes in FiO2 and PaO2 and potential associated O2 diffusion between urine and ureteric or bladder tissue. We aimed to investigate PuO2 measurements in septic shock patients with a fiberoptic luminescence optode inserted into the urinary catheter lumen in relation to episodes of FiO2 change. We also evaluated medullary and urinary oxygen tension values in Merino ewes at two different FiO2 levels.ResultsIn 10 human patients, there were 32 FiO2 decreases and 31 increases in FiO2. Median pre-decrease FiO2 was 0.36 [0.30, 0.39] and median post-decrease FiO2 was 0.30 [0.23, 0.30], p = 0.006. PaO2 levels decreased from 83 mmHg [77, 94] to 72 [62, 80] mmHg, p = 0.009. However, PuO2 was 23.2 mmHg [20.5, 29.0] before and 24.2 mmHg [20.6, 26.3] after the intervention (p = 0.56). The median pre-increase FiO2 was 0.30 [0.21, 0.30] and median post-increase FiO2 was 0.35 [0.30, 0.40], p = 0.008. PaO2 levels increased from 64 mmHg [58, 72 mmHg] to 71 mmHg [70, 100], p = 0.04. However, PuO2 was 25.0 mmHg [IQR: 20.7, 26.8] before and 24.3 mmHg [IQR: 20.7, 26.3] after the intervention (p = 0.65). A mixed linear regression model showed a weak correlation between the variation in PaO2 and the variation in PuO2 values. In 9 Merino ewes, when comparing oxygen tension levels between FiO2 of 0.21 and 0.40, medullary values did not differ (25.1 ± 13.4 mmHg vs. 27.9 ± 15.4 mmHg, respectively, p = 0.6766) and this was similar to urinary oxygen values (27.1 ± 6.17 mmHg vs. 29.7 ± 4.41 mmHg, respectively, p = 0.3192).ConclusionsChanges in FiO2 and PaO2 within the context of usual care did not affect PuO2. Our findings were supported by experimental data and suggest that PuO2 can be used as biomarker of medullary oxygenation irrespective of FiO2.