Ferioli & Gianotti (Italy)

This paper will analyse the psychological growth of Lenny, the young lead character in Bapsi Sidhwa's Ice Candy Man, who is traumatised by the partition of India in 1947. Exploring the experience of Lenny as she goes through life as a naive and as an educated person, the dissertation pays attention to how the exposure to mass violence, grief and division of the community affects the perception of community by Lenny as an individual, as well as her identity and morality. Applying a qualitative approach — more specifically, the content analysis of the novel — the study attempts to track Lenny's psychological evolution. The research is a qualitative content analysis that will identify themes and key passages in Ice Candy Man by Paul Scott to show that Lenny has a psychological problem. It is psychoanalytically unzipped in accordance with Lacanian vision, in line with Lenny's metamorphosis of identity and vision. It has also been discovered that exposure to violence in the partition caused psychological development in Lenny. She dreams at night, she shuns emotional contact, she is more conscious of the nuances of force, sex and deceit. Only at this point do we witness her metamorphosis as she crosses the boundary between innocence and an adult world where identity and human relationships are weak. The paper recommends applying evidence-based trauma-informed interventions in conflict situations, such as offering emotional support, promoting resilience, and creating safe spaces for children. In addition, the research shows how literary analysis and psychological theory can be applied simultaneously to comprehend the long-term effects of violence on children's lives.

Future collider experiments place demands on hybrid pixel detectors, particularly in terms of interconnect reliability across a range of die sizes and fine-pitch geometries. In development workflows based on Multi-Project Wafer (MPW) submissions, support for single-die assembly is crucial. To address these challenges, new hybridization methods have been introduced through collaborative efforts at CERN and within the AIDAinnova framework. One such approach utilizes Anisotropic Conductive Film (ACF) combined with Electroless Nickel Immersion Gold (ENIG) surface treatment to form interconnections without conventional solder bumps. Instead, conductive microparticles embedded in an adhesive layer are compressed under heat and pressure to establish electrical contact. This technique has demonstrated excellent yield and mechanical stability, especially for pitches below 100 µm, making it a strong candidate for advanced detector integration in high-energy physics applications.

Maqolada So‘x daryosining konus yoyilmasida shakllangan dastlabki tuproqlar ustida agroirrigatsion qatlamlarning shakllanishi, sug‘orish suvlarining tarkibi, loyqalilik darajasi uning mexanik tarkibi keltirilgan bo‘lib, fizik-kimyoviy va biologik xossalariga ta’siri hamda o‘zgarishi tahlil qilingan. So‘x daryosi qalqindisi, ya’ni loyqa miqdorining ko‘pligi bilan Janubiy Farg‘ona daryolarining ichida yetakchilik qilishiga alohida e’tibor qaratilgan. Daryoning konus yoyilmasida allyuvial-prollyuvial yotqiziqlar ustida shakllangan sug‘oriladigan kolmatajlangan tuproqlarning shakllanishida daryo qalqindilari yetarli darajada genezis vazifasini bajarishi va har xil qalinlikdagi agroirrigatsion qatlamlarni shakllanishi yoritilgan. Kalit so‘zlar: agroirrigatsion qatlam, konus yoyilma, akkumulyatsiya, daryo suvlari, dehqonchilik, kimyoviy tarkib, suvning loyqalilik darajasi, qalqindi, mexanik tarkib.

In tokamaks, a leading platform for fusion energy, periodic filamentary plasma eruptions known as edge-localized modes occur in plasmas with high-energy confinement and steep pressure profiles at the plasma edge. These edge-localized modes could damage the tokamak wall but can be suppressed using small three-dimensional magnetic perturbations. Here we demonstrate that these magnetic perturbations can change the magnetic topology just inside the steep gradient region of the plasma edge. We identify signatures of a magnetic island, and their observation is linked to the suppression of edge-localized modes. We compare high-resolution measurements of perturbed magnetic surfaces with predictions from ideal magnetohydrodynamic theory where the magnetic topology is preserved. Although ideal magnetohydrodynamics adequately describes the measurements in plasmas exhibiting edge-localized modes, it proves insufficient for plasmas where these modes are suppressed. Nonlinear resistive magnetohydrodynamic modelling supports this observation. Our study experimentally confirms the predicted role of magnetic islands in inhibiting the occurrence of edge-localized modes. This will be beneficial for physics-based predictions in future fusion devices to control these modes.

The aim of this study was to assess the effect of gadopiclenol versus gadobenate dimeglumine contrast-enhanced magnetic resonance imaging (MRI) on decision-making between whole-brain radiotherapy (WBRT) and stereotactic radiosurgery (SRS) for treatment of brain metastases (BMs). Patients with BMs underwent 2 separate MRI examinations in a double-blind crossover phase IIb comparative study between the MRI contrast agents gadopiclenol and gadobenate dimeglumine, both administered at 0.1 mmol/kg. The imaging data of a single site using identical MRI scanners and protocols were included in this post hoc analysis. Patients with 1 or more BMs in any of both MRIs were subjected to target volume delineation for treatment planning. Two radiation oncologists contoured all visible lesions and decided upon SRS or WBRT, according to the number of metastases. For each patient, SRS or WBRT treatment plans were calculated for both MRIs, considering the gross target volume (GTV) as the contrast-enhancing aspects of the tumor. Mean GTVs and volume of healthy brain exposed to 12 Gy (V 12 ), as well as Dice similarity coefficient scores, were obtained. The Spearman rank (ρ) correlation was additionally calculated for assessing linear differences. Three different expert radiation oncologists blindly rated the contrast enhancement for contouring purposes. Thirteen adult patients were included. Gadopiclenol depicted additional BM as compared with gadobenate dimeglumine in 7 patients (54%). Of a total of 63 identified metastatic lesions in both MRI sets, 3 subgroups could be defined: A, 48 (24 pairs) detected equal GTVs visible in both modalities; B, 13 GTVs only visible in the gadopiclenol set (mean ± SD, 0.16 ± 0.37 cm 3 ); and C, 2 GTVs only visible in the gadobenate dimeglumine set (mean ± SD, 0.01 ± 0.01). Treatment indication was changed for 2 (15%) patients, 1 from no treatment to SRS and for 1 from SRS to WBRT. The mean GTVs and brain V 12 were comparable between both agents ( P = 0.694, P = 0.974). The mean Dice similarity coefficient was 0.70 ± 0.14 (ρ = 0.82). According to the readers, target volume definition was improved in 63.9% of cases (23 of 36 evaluations) with gadopiclenol and 22.2% with gadobenate dimeglumine (8 of 36), whereas equivalence was obtained in 13.9% (5 of 36). Gadopiclenol-enhanced MRI improved BM detection and characterization, with a direct impact on radiotherapy treatment decision between WBRT and SRS. Additionally, a more exact target delineation and planning could be performed with gadopiclenol. A prospective evaluation in a larger cohort of patients is required to confirm these findings.

With sustainability dominating the industry, recycling the generated waste from different processes is becoming increasingly important. This study focuses on recycling waste generated during aluminum anodizing waste (AAW) in friction material formulations for automotive braking applications. However, before utilization, the waste needs to be pre-treated, which mainly involves drying. Hence, four different industrial drying methods were studied to dry the AAW, and the corresponding characteristics were observed by evaluating its residual humidity and crushability index. The waste powders were further characterized using FT-IR and SEM/EDXS to understand their constituents. The initial analysis showed that the waste subjected to the drying process P2 and P1 with the lowest final humidity fetched the most desirable results, with P1 having the simpler drying procedure. The AAW powders were added in a commercial friction material formulation at 6 and 12 wt.% and subjected to friction, wear, and non-exhaust particulate matter analysis. The worn surfaces were analyzed using SEM/EDXS evaluation to understand the extension and composition of the deposited secondary contact plateaus. It was seen that the 12 wt.% addition of waste processed using the P1 technique provided the most satisfactory friction, wear, and emission characteristics, along with expansive secondary contact plateaus with a good contribution of the waste in its formation. This study showed a good relationship between the processing method and a formulation’s tribological and emission characteristics, thereby paving the way for using this drying method for other waste requiring pre-treatment.

Introduction: The study aims to compare the efficacy and safety of bulking agents and single-incision slings in the treatment of urinary incontinence in 159 patients during a 29-month follow-up period. Material and methods: Of the 159 patients suffering from stress urinary incontinence, 64 were treated with bulking agents (PAHG Bulkamid®) and 75 with a single-incision sling (Altis®). The ICIQ-UI-SF (Incontinence Questionnaire-Urine Incontinence-Short Form), PISQ-12 (Pelvic Organ Prolapse/Urinary Incontinence Sexual Questionnaires short form), FSFI (Female Sexual Function Index), FSDS (Female Sexual Distress Scale), and PGI-I (Patient Global Improvement Index) were used to assess efficiency and quality of life. Results: The bulking agents showed high efficacy and safety during the 29-month follow-up. Post-operative complications were recorded in both groups, with only two significant differences. The Bulkamid group experienced no pain, while 10.8% of the ALTIS group experienced groin pain and 5% experienced de novo urgency. Furthermore, patients treated with bulking agents experienced reduced nicturia (0.78 vs. 0.92 in patients treated with single-incision slings.). In both groups, we noticed a significant improvement in QoL (quality of life), with a halved ICIQ-UI-SF (International Consultation on Incontinence Questionnaire-Urine Incontinence-Short Form) score which was completed to assess the impact of urine symptoms. After 24 months of therapy, the Bulkamid group saw a decrease from 14.58 ± 5.11 at baseline to 5.67 ± 1.90 (p < 0.0001), whereas the ALTIS group experience a decrease from 13.75 ± 5.89 to 5.83 ± 1.78. Similarly, we observed an improvement in sexual function, with the number of sexually active patients increasing from 29 to 44 (56.4%) in the Bulkamid group (p = 0.041) and from 31 to 51 (61.7%) in the ALTIS group (p = 0.034). According to the most recent statistics, the PISQ-12, FSFI, and FSDS scores all demonstrated an improvement in women’s sexual function. Conclusions: In terms of efficacy and safety, bulking agents had notable results over the 29-month follow-up period. Furthermore, the patients treated with bulking agents reported a lower incidence of postoperative complications and a no discernible difference in terms of quality of life and sexual activity compared to the ones treated with single-incision slings. Bulking agents can be considered a very reliable therapeutic option based on accurate patient selection.

Este estudo tem por objetivo analisar as implicações da alteração do nome no Cartório de Registro Civil sem a necessidade de intervenção judicial, para a utilização do nome social sem a submissão à cirurgia de redesignação sexual. Assim, aborda-se o posicionamento do Supremo Tribunal Federal nos autos do Recurso Extraordinário nº 670.422, de relatoria do Ministro Dias Toffoli, julgado Corte em agosto de 2018, bem como a edição do Provimento nº 73, do Conselho Nacional de Justiça. Trata-se de decisão paradigmática que reconhece o direito de o transexual ter o seu nome e classificação de gênero alterados no registro de nascimento ainda que não tenha realizado cirurgia de redesignação sexual, sendo possível a retificação do nome junto ao Cartório de Registro competente, sem pronunciamento judicial. Contudo, não se pode ignorar os reflexos sociais e jurídicos, pois a omissão quanto ao sexo biológico pode ir de encontro ao princípio da boa-fé.

ABSTRACT The optimal management of second stage of labor, with its passive and active phases, remains controversial. In France, delayed pushing during the active phase is recommended because of the belief that, based on older data, the fetus is at higher risk during the active phase. It is possible that uterine contractions combined with maternal pushing can lead to cord compression and reduce placental perfusion and oxygenation, which can induce acidosis and fetal heart rate abnormalities, resulting in the need for medical intervention, such as operative vaginal delivery (OVD) or episiotomy. In countries where the active phase is limited, women are encouraged to push as strongly as possible to speed delivery. However, if the active second stage of labor is prolonged, this intensive management may increase fetal hypoxia. The aim of this study was to examine the effect of moderate pushing versus intensive pushing in the second stage of labor on the risk of neonatal morbidity. This was a multicenter, randomized controlled trial at 13 French maternity units between January 2017 and May 2020. Included were nulliparous, adult women who had spontaneous or induced, uncomplicated delivery of a singleton fetus at ≥37 weeks of gestation. Excluded were women with a psychiatric condition, a disease contraindicating intensive expulsive efforts, or any uterine surgical scar, as well as those with a fetus that was small for gestational age, had congenital abnormalities, or had abnormal heart rate. Eligible women were randomized into 2 groups: the intervention group was instructed to push moderately only during the active phase of the second stage of labor, and the control group was instructed to push intensively during the same phase following French recommendations. Midwives asked the intervention group to push 2 times during each contraction and to take a break with no pushing in 1 of 5 contractions. No limit was set on pushing duration. The control group was asked to push 3 times per contraction without breaks. After 30 minutes of pushing, the midwife contacted an obstetrician to consider operative delivery. The primary outcome was a composite of neonatal acidosis, a 5-minute Apgar score &lt;7, and/or severe neonatal trauma. Secondary neonatal outcomes were transfer to the neonatology unit or intensive care unit need for resuscitation at birth and need for hypothermia. Secondary maternal outcomes were mode of delivery, postpartum hemorrhage (PPH), and severe PPH. The trial was stopped prematurely because of difficulties obtaining an adequate sample size. Of the 3380 women initially planned, 1710 (50.6%) were included. Ultimately, the intention-to-treat analysis included 809 women in each group. The neonatal morbidity rates for the intervention group and control group were 18.9% and 20.6%, respectively (risk ratio [RR] 0.92; 95% confident interval [CI], 0.75–1.12; P = 0.38). No significant differences were observed for neonatal transfer or need for resuscitation. All but 16 women delivered vaginally. The intervention or moderate pushing group had a longer pushing duration than the control or intensive pushing group (38.8 ± 26.4 vs 28.6 ± 17.0 minutes; P &lt; 0.001) and lower episiotomy rate (13.5% vs 17.8%; RR, 0.76; 95% CI, 0.60–0.95; P = 0.02). The rates of OVD were 21.1% in the intervention group and 24.8% in the control group (RR, 0.85; 95% CI, 0.71–1.02; P = 0.08). No significant differences were observed for PPH or severe PPH. During the active stage of labor, encouraging women to push moderately versus intensively was not associated with decreased neonatal morbidity. Although the pushing duration was longer among women instructed to push moderately, the rate of episiotomy was lower.