Forecasting International (United States)

We developed a grating-based specialty single-mode fiber that is compatible with most distributed acoustic/vibrational sensing interrogators. Laboratory and field-based testing results with improved sensing performance including SNR and position accuracy will be discussed. Full-text article not available; see video presentation

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Ribonucleoside and deoxyribonucleoside triphosphate pools have been measured in Escherichia coli infected with bacteriophage T4 DNA polymerase mutator, wild type, and antimutator alleles during mutagenesis by the base analogue 2-aminopurine. ATP and GTP pools expand significantly during mutagenesis, while CTP and UTP pools contract slightly. The DNA polymerase (gene 43) alleles and an rII lesion perturb normal dNTP pools more than does the presence of 2-aminopurine. We find no evidence that 2-aminopurine induces mutations indirectly by causing an imbalance in normal dNTP pools. Rather, it seems likely that, by forming base mispairs with thymine and with cytosine, 2-aminopurine is involved directly in causing bidirectional A.T in equilibrium G.C transitions. The ratios for 2-aminopurine deoxyribonucleoside triphosphate/dATP pools are 5-8% for tsL56 mutator and 1-5% for tsL141 antimutator and 43+ alleles. We conclude that the significant differences observed in the frequencies of induced transition mutations in the three alleles can be attributed primarily to the properties of the DNA polymerases with their associated 3'-exonuclease activities in controlling the frequency of 2-aminopurine.cystosine base mispairs.

Professor Albert H. Rubenstein has been Editor of the ENGINEERING MANAGEMENT TRANSACTIONS OF THE IRE and starting in 1963, the IEEE since 1958. In 1983 when I was President of the Engineering Management Society (EMS), Al informed me that 25 years as editor was sufficient, and that we should start the search for his successor. With his guidance we completed that search in 1984. He will officially retire as editor at the end of 1985.