Frequency Therapeutics (United States)

In this paper, a 323.2 GHz detector using second harmonic injection locking with dual polarization detection is presented. The Second harmonic injection locking based on cross-coupled oscillator is introduced to enhance the sensitivity. The signal detection is achieved through oscillation amplitude modulation with high responsivity and low noise equivalent power (NEP). A single-loop inductor at the drain and slot etching at the source act as the receiving antenna to capture the signal of different polarization directions, respectively. The proposed THz detector is fabricated in 40 nm CMOS technology. A responsivity of 744/485 kV/W and a NEP of 0.44/0.69 ${\text{pW}}/\sqrt {{\text{Hz}}} $ are measured at 323.2 GHz on dual polarization directions.

An electro-thermal co-designed and wideband circularly polarized Archimedean spiral antenna is proposed in this paper. This antenna containing two metal heat-dissipating fins shaped like Archimedean spiral arms. For enhanced the impedance matching, the heatsink is designed with a height gradient. The performance of the antenna indicates that the overlapping axial ratio bandwidth and -10-dB impedance bandwidth are covering the frequency range from 5 to 22.56 GHz (127.5%). When subjected to a heat source power of 0.5 W and the environment temperature of 293 K, the rising temperature of proposed antenna is 12.3 K lower compared to the microstrip spiral antenna.

We present our recent progress of developing the new CSAC physics package design. Through using right-angle solder joint connections, the wafer scale assembled cores can be integrated into the polyimide suspension in a vacuum package. This approach is the key innovation to achieve low-cost volume manufacturing. We will present the novelties we have done in the core components, including advanced wafer-scale manufacturing of the vapor cells, utilization of metasurface optics to achieve both beam shaping and polarization conversion, and utilization of narrow linewidth VCSELs based on an extended laser cavity. We will also present the clock performance based on a custom-made microwave synthesizer application-specific integrated circuit, which contributes to the power consumption reduction as well as the reduction of required board size.

Summary—This paper describes the recent achievements on absolute calibration of GNSS receivers using a newly purchased Safran GSG-7 GNSS simulator. First, we detail our investigations on the suitability of this simulator for the purpose of absolute calibration of GNSS receiver chains. Then, we compare the calibration results obtained with four different simulators for a given GNSS receiver. Absolute calibration of an OP G1/G2 travelling receiver chain is also performed and compared to the relative calibration result.

Abstract As the pursuit of high-quality display panels intensifies, the importance of high-performance thin-film transistors (TFTs) becomes increasingly prominent. Indium tin zinc oxide (ITZO) TFTs, as one of the promising directions for high-performance metal oxide TFTs, impose high demands on their performance and reliability. In this study, the performance and stability of ITZO TFTs fabricated under different radio-frequency magnetron sputtering power conditions were systematically tested and investigated. After sputtering power optimization, the field effect mobility of ITZO TFTs reaches 29.68 cm2V–1.s, with a steep sub-threshold swing of 0.17 V/decade, near-zero threshold voltage, and good stability. Using atomic force microscopy and x-ray photoelectron spectroscopy characterization techniques, the thin films were analyzed to elucidate the relationship between sputtering power variations and oxygen vacancies.

Abstract We present the development of alkali-alloy-based vapor cells for operating a cesium-based Chip-Scale Atomic Clock (CSAC) at environmental temperatures up to 105 °C. Leveraging Raoult’s Law for a mixture of potassium and cesium metal, we have demonstrated vapor pressure suppression equivalent to 25 °C, allowing a CSAC to operate at higher temperatures with minimal degradation of performance or power consumption.

In this paper, we report on the innovative design and performance of the Timing Unit Rubidium Oscillator (TURbO). TURbO is a compact, lamp-based, double resonance rubidium clock. Its design incorporates full digital control for the physics package environmental and clock control loop electronics. The TURbO unit is designed to provide superior performance as compared to other compact rubidium clocks currently available while under harsh dynamic environmental conditions. This is accomplished by reducing the size of the rubidium physics package, and miniaturizing the associated control electronics. Another key aspect of the new compact design is the integrated 10MHz silicon oscillator that replaces the traditional quartz oscillator. TURbO is engineered to be virtually vibration insensitive and to meet performance over a temperature range from -40°C to +71°C.

Ototoxin cyclodextrin (CDX) will induce a burst in serum prestin when quantified with automated Western blot analysis. In the clinical realm, we primarily rely on audiological measures for diagnosis and surveillance of sensorineural hearing loss (SNHL) and have limited therapeutic options. We have proposed a blood-based biomarker approach to overcome this challenge by measuring the outer hair cell's (OHC) electromotile protein, prestin, in the blood. Previously, we demonstrated a burst in serum prestin after cisplatin exposure using enzyme-linked immunosorbent assayELISA. Guinea pigs were treated with either 3,000 or 4,000 mg/kg CDX, and serum samples were obtained through 3 days after exposure. Serum prestin levels were quantified using automated blot analysis, western and hair cell counts were obtained. Both 3,000 and 4,000 mg/kg resulted in robust OHC loss, although more variability was seen at the lower dose. Automated Western blot analysis demonstrated that the prestin profile after CDX exposure is different than baseline. Specifically, a new ~134- kDa band accounted for the prestin burst after ototoxin ablation of OHCs at both doses. We reproduced the prestin burst seen after cisplatin administration using CDX. Automated Western blot western analysis revealed that a ~a ~ 134- kDa species of prestin is responsible for the burst. We suggest that the induced band may be a prestin dimer, which could serve as a biomarker for early detection of ototoxicity in the clinical setting. These results add further promise to the potential of serum prestin to serve as an ototoxicity biomarker when using therapeutics with ototoxic properties.

Stewart Wallace made many contributions in his life, most notably to the development of the APT700 frequency band, the Asia Pacific Telecommunity 700 MHz spectrum, now used on mobile phones in many parts of the world. He was also an admired bagpiper, invited to play at Royal Edinburgh Military Tattoos, ANZAC commemorations and as a solo piper. Through the diversity of his upbringing, education, varied life experiences, and openness to new challenges, together with passion for each of these while also being a good listener and communicator, Stewart Wallace achieved an enviable balance of humanity and global success, doing what he loved best.