GDP Ayurvedic University

Abstract BACKGROUND: The potential of lncRNA in hepatocellular carcinoma (HCC) has led to promising insights in therapeutic intervention. The clinical significance of LINC02518 in HCC is unclear. This study aimed to evaluate the predictive value of a novel long non-coding RNA LINC02518 for the prognosis of patients with HCC. METHODS: Between December 2005 and November 2011, 125 HCC patients in training group and 75 HCC patients in validation group who underwent liver surgery were involved in our study. The LINC02518 expression of HCC and corresponding non-tumor liver tissues was detected by microarray and qRT-PCR. These HCC patients were divided into high and low LINC02518 expression groups based on the threshold of the receiver operating characteristic curve. Kaplan-Meier analysis was performed to determine the prognosis of HCC patients.RESULTS: LINC02518 expression was upregulated in paired tumor samples compared to that in corresponding non-tumor samples in two groups. The areas under the receiver operating characteristic curve for the levels of LINC02518 in the diagnosis of HCC was 0.66, 95% CI: 0.59–0.73. HCC patients with high LINC02518 expression had significantly worse tumor recurrence-free, metastasis-free, disease-free, and overall survival than those with low LINC02518 expression.CONCLUSIONS: LINC02518 is negatively correlated with the prognosis of HCC and provides a promising strategy for the treatment and prognosis of HCC.

Diabetes mellitus (Madhumeha) is a metabolic disorder which affects almost all the system of body. patient were registered with the help of Performa prepared for study 100 patient were taken for this observational study Drug Haridra Amalaki yoga were administered in dose of 8 gm per day with water Effect of therapy was assessed by sign symptom and blood sugar level before and after treatment. It was assessed by basis of self formulated scale. All patient were treated with 4 gm of Haridra Amalaki yoga with water twice daily for two month. Periodical checkup and follow up were conducted once in 15 days.Statistical analysis reveal that in the management of Diabetes mellitus the efficacy of Haridra amalaki yoga is effective.By using Haridra amalaki yoga in the management of madhumeha showed a significant result. Haridra Amalaki yoga in management of Madhumeha shows a positive result.

During 1993 and 1994, the author took part in the South West Orthodontic Clinical Assistant Training Programme and worked as a part-time Clinical Assistant in the Orthodontic Department of the Royal United Hospital, Bath. Following the clinical assistantship the author continued to treat patients in the hospital department but under a General Dental Services contract number. This paper is a personal clinical audit of all the orthodontic cases completed within the GDS by the author since 1990, both in general practice in Westbury, Wiltshire and at the Royal United Hospital (RUH), Bath. The aim of the audit was to evaluate the effectiveness of orthodontic treatment carried out by the author, both in general dental practice and in a hospital orthodontic department, and to compare treatment outcomes with other published results.