General Dynamics (Canada)

<strong class="journal-contentHeaderColor">Abstract.</strong> Grand Lake, located in Labrador, at the northeastern margin of North America, is a deep lacustrine basin that contains a well-preserved annual laminations record spanning the interval 493 to 2016 CE (1524 years). The chronology of this new varved sequence is established from layer counting of high-resolution images of thin sections. Radiometric dating (¹³⁷Cs and ¹⁴C) validates the reliability of the varve chronology. Varve thickness is significantly correlated (<em>r</em> = 0.38) with the total precipitation recorded at the nearest weather station Goose A. The varve thickness series reveals high values during the 1050&ndash;1225 CE period, that is corresponding to the Medieval Climate Anomaly, whereas the 15th&ndash;19th centuries, related to the Little Ice Age, shows low values. The teleconnections between several Goose A instrumental data series and some modes of climate variability such as the winter Greenland Blocking (negative North-Atlantic Oscillation) and the significant correlations between our varve thickness record and three other Northern Hemisphere high-resolution proxy records suggest that the Grand Lake record tracks North-Western Atlantic large-scale mode of hydroclimate variability over the past ~1500 years.

• Examines trajectory integration: recombining multiple inventions within a shared pre-existing trajectory. • Inner-domain trajectory integration is associated with higher impact within the focal domain but lower impact outside it. • Outer-domain trajectory integration is associated with higher impact outside the focal domain. • Emphasizes relevance of shifting from a static to a dynamic trajectory-based perspective in domain search strategies. This study introduces the concept of trajectory integration in recombinant search, where inventors recombine multiple inventions from a shared pre-existing trajectory. As inventions within a trajectory build upon their predecessors, we theorize that inventors can learn from these interconnections to develop more effective approaches to new problems. We argue that the benefits of trajectory integration depend on whether inventions in the trajectory belong to the focal domain (inner-domain trajectory integration) or lie outside it (outer-domain trajectory integration). Analyzing 19,266 nuclear energy patent families, we find that inner-domain trajectory integration is linked to higher impact within the focal domain but lower impact outside it. Conversely, outer-domain trajectory integration is associated with impact beyond the focal domain but shows no link to impact within it. We contribute to recombinant search literature by highlighting the relevance of considering the historical context of inventions and their trajectories to better understand their value.

<strong class="journal-contentHeaderColor">Abstract.</strong> Grand Lake, located in Labrador, at the northeastern margin of North America, is a deep lacustrine basin that contains a well-preserved annual laminations record spanning the interval 493 to 2016 CE (1524 years). The chronology of this new varved sequence is established from layer counting of high-resolution images of thin sections. Radiometric dating (¹³⁷Cs and ¹⁴C) validates the reliability of the varve chronology. Varve thickness is significantly correlated (<em>r</em> = 0.38) with the total precipitation recorded at the nearest weather station Goose A. The varve thickness series reveals high values during the 1050&ndash;1225 CE period, that is corresponding to the Medieval Climate Anomaly, whereas the 15th&ndash;19th centuries, related to the Little Ice Age, shows low values. The teleconnections between several Goose A instrumental data series and some modes of climate variability such as the winter Greenland Blocking (negative North-Atlantic Oscillation) and the significant correlations between our varve thickness record and three other Northern Hemisphere high-resolution proxy records suggest that the Grand Lake record tracks North-Western Atlantic large-scale mode of hydroclimate variability over the past ~1500 years.

To examine elevated symptoms on health-related quality of life (HRQOL) measures over 2 years in caregivers of service members with traumatic brain injury (TBI). To compare outcomes to caregivers of veterans. Caregivers (N = 315) were classified into two groups: (a) service member caregiver group (n = 55) and (b) veteran caregiver group (n = 260). Caregivers completed 17 HRQOL measures at a baseline evaluation and follow-up evaluation 24 months later. In the service member caregiver group, the highest frequency of clinically elevated T-scores (≥ 60 T) at baseline and follow-up were found on physical and psychological HRQOL measures (16.4%-30.9%). A higher proportion of the veteran caregiver group had clinically elevated scores on nine measures at baseline and seven measures at follow-up. Examining the number of clinically elevated scores simultaneously across all 17 measures, the service member caregiver group had multiple elevated scores (e.g., 4 or more: baseline = 25.5%, follow-up = 27.3%). A higher proportion of the veteran caregiver group had multiple clinically elevated scores for 13 comparisons at baseline (h = .35-.82), but reduced to eight comparisons at follow-up (h = .36-.63). In the service member caregiver group, the proportion of caregivers with clinically elevated scores at baseline and follow-up was equally dispersed across persistent and newly developed symptoms, but higher for persistent symptoms compared to developed symptoms in the veteran caregiver group. Many caregivers of service members reported clinically elevated scores across HRQOL domains and the prevalence increased over 2 years. More services for caregivers in the Department of Defense may be helpful in reducing the trajectory of newly developed symptoms long term. (PsycInfo Database Record (c) 2025 APA, all rights reserved).

&lt;title&gt;ABSTRACT&lt;/title&gt; &lt;p&gt;This paper presents a novel approach for modeling LAV-terrain systems in a dynamic simulation environment, which is based on results from the research and development of advanced technologies by the Computer Modeling and Simulation team of General Dynamics Land Systems-Canada (GDLS-C). The presented soil-tire model has been developed based upon the application of terra-mechanics and is being uniquely integrated with a full 8x8 LAV model in ADAMS/View, with incorporation of large tire deflections and multi-passing effect. It is shown that the highly efficient soil-tire model is capable of dynamically predicting soil sinkage, tire deflection, wheel slip, rolling resistance, drawbar pull and actual torque created at each soil-tire interface, as required by the mobility analysis of LAV systems over soft terrains.&lt;/p&gt;

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Proper derivation of CH3NH3PbX3 (CH3NH3+ = methyl ammonium or MA+; X- = Cl-, Br-, I-) optical constants is a critical step toward the development of high-performance electronic and optoelectronic perovskite devices. To date, the optical dispersion regimes at, above, and below the band gap of these materials have been inconsistently characterized by omitting or under-approximating anomalous spectral features (from ultraviolet to infrared wavelengths). In this report, we present the rigorous optical dispersion data analysis of single crystal MAPbBr3 involving variable angle spectroscopic ellipsometry data appended with transmission intensity data. This approach yields a more robust derivation of MAPbBr3 optical constants (refractive index, n, and extinction coefficient, k) for both anomalous (absorptance) and normal (no absorptance) optical dispersion regimes. Using the derived optical constants for our MAPbBr3 single crystals, illustrative modeled solar cell device designs are presented in relation to non-realistic designs prepared using representative optical constants reported in the literature to date. In comparison, our derived optical dispersion data enables the modeled design of realistic planar perovskite solar cell (PSC) optical performance where the active layer (MAPbBr3) is optimized for maximum solar radiation absorption. We further demonstrate optimized modeled planar PSC designs with minimal parasitic optical absorptance in non-active PSC device layers resulting in improved performance at broad angles of incidence (approximately 0-70°). Our robust derivation of MAPbBr3 optical properties is expected to impact the optical dispersion data analysis of all perovskite analogs and expedite targeted development of, for example, solar cell, light-emitting diode, photo and X-ray/γ-ray detector, and laser system technologies.

Developmental hazard evaluation is an important part of assessing chemical risks during pregnancy. Toxicological outcomes from prenatal testing in pregnant animals result from complex chemical-biological interactions, and while New Approach Methods (NAMs) based on in vitro bioactivity profiles of human cells offer promising alternatives to animal testing, most of these assays lack cellular positional information, physical constraints, and regional organization of the intact embryo. Here, we engineered a fully computable model of the embryonic disc in the compucell3d.org modeling environment to simulate epithelial-mesenchymal transition of epiblast cells and self-organization of mesodermal domains (chordamesoderm, paraxial, lateral plate, posterior/extraembryonic). Cell fate in the model is determined by an autonomous homeobox (HOX) clock driven by morphogenetic signals (e.g., FGF, WNT, ATRA, CDX). Executing the model renders a quantitative cell-level computation of mesodermal subpopulations and consequences of perturbation based on known embryogeny. For example, synthetic perturbation of the control network rendered altered phenotypes (cybermorphs) mirroring experimental mouse embryology, with 50% reductions in FGF4, FGF8 and BMP4 signaling resulting in 86%, 98% and 59% reductions, respectively in the posterior mesodermal population, while ATRA exposure also resulted in a 78% decrease in this population. This model enables integration of in vitro chemical bioactivity data for specific molecular targets with known embryology to test mechanistic veracity and quantitative prediction of altered development.