Goodwin (United Kingdom)

Abstract MarBN steels, originally developed by Professor Fujio Abe at NIMS Japan, have undergone significant advancement in the UK through a series of government-funded collaborative projects (IMPACT, IMPEL, INMAP, IMPULSE, and IMPLANT). These initiatives have achieved several major milestones, including operational power plant trials, full-scale extruded pipe production, matching welding consumable development, and most notably, the creation of IBN-1—a new steel demonstrating 30-45% higher creep strength than Grade 92. However, like other creep strength-enhanced ferritic steels, IBN-1 shows reduced creep ductility under the lower stress conditions typical of operational use. Since adequate creep ductility is essential for component damage tolerance and effective in-service monitoring, this study investigates the effects of an alternative normalizing and tempering heat treatment on cast IBN-1. The research presents creep rupture test results showing improved ductility and analyzes the microstructural mechanisms responsible for this enhancement.

Children with cerebral palsy (CP) who walk have complex gait patterns and deviations often requiring physical therapy (PT)/medical/surgical interventions. Walking in children with CP can be assessed with 3-dimensional instrumented gait analysis (3D-IGA) providing kinematics (joint angles), kinetics (joint moments/powers), and muscle activity. This clinical practice guideline provides PTs, physicians, and associated clinicians involved in the care of children with CP, with 7 action statements on when and how 3D-IGA can inform clinical assessments and potential interventions. It links the action statement grades with specific levels of evidence based on a critical appraisal of the literature. This clinical practice guideline addresses 3D-IGA's utility to inform surgical and non-surgical interventions, to identify gait deviations among segments/joints and planes and to evaluate the effectiveness of interventions. Best practice statements provide guidance for clinicians about the preferred characteristics of 3D-IGA laboratories including instrumentation, staffing, and reporting practices.Video Abstract: Supplemental digital content available at http://links.lww.com/PPT/A524.

Nicolas Abraham’s “Introducing Thalassa” contributed to the revival of Sàndor Ferenczi’s ideas in France from the 1960s and initiated a transformation in his own psychoanalytic thinking as the thalassal argument was brought into a new context. This article argues that Abraham’s work provides a pathway to not only remember, but also revitalise Ferenczi’s notion of trauma and its inscription in biological processes from events that have happened is species pre-history as well as personal history. Abraham rethinks this “biological unconscious” through a unique conception of the symbol that is inherently unstable and always responding anew to trauma it also continually reformulates. This allows us to understand the body in different terms, away from a series of biological processes to which psyche can be reduced, towards a notion of the somatic that is eloquent and unpredictable and must be translated by the psyche and any apprehending discourse. This transformation made the body relevant once more in a French context that was suspicious of its blanket positing as the cause of psychical processes. Situating the origins of subjectivity in the somatic ever-displaces causal processes in the body so that we can never quite grasp these and must search for them across different, although related, levels of meaning. The search for origins is essential but never satisfactory hence my use of translation as a frame for understanding Abraham’s work; a process that is always unfinished and invites further response.

The current BSAVA president’s criticism of James Herriot/Alf Wight is inappropriate, if not arrogant ( VR , 27 April 2019, vol 184, p 514). > The James Herriot image allowed the profession to be uniquely popular with, and respected by, the public for …

Abstract Overexpression of the Tyrosine Kinase, Focal Adhesion Kinase (FAK) has been implicated in the development of resistance to front line agents, cisplatin and paclitaxel, in the treatment of ovarian cancer. Moreover vitamins such as Pyridoxal 5′ phosphate (PLP) has been shown to induce cytotoxicity in cancers. Therefore, the aim of this study was to assess the cytotoxic efficacy of FAK inhibition using 1,2,4,5-Benzenetetraamine tetrahydrochloride (Y15) and PLP combined with cisplatin and paclitaxel. Platinum resistant OVCAR-3 cells were treated with varying concentrations of Y15 (10μM, 15 μM, 30 μM, 100 μM), and PLP (0.25mM, 1mM, 2Mm). Cells were also treated with Y15 + PLP, Y15 + Cisplatin + Paclitaxel, PLP + cisplatin + paclitaxel and Cisplatin + paclitaxel for 24 hrs in triplicate and control cells with 2N HCl or media only. The cytotoxic profile of each treatment was assessed using the automated trypan blue assay and DNA fragmentation assay was performed to evaluate the mechanism of cell death. Dose dependent and statistically significant cytotoxicities were seen with Y15 and PLP compared to the controls with IC 50 values 80 μM (p <0.05) and 2 mM (p<0.05) respectively. The use of Y15 in combination with PLP showed enhanced cytotoxic efficacy in OVCAR-3 cell (p<0.0001). Similarly, Y15 significantly increased percentage cell death when combined with cisplatin + paclitaxel (62%, p<0.0001) in comparison to cisplatin + paclitaxel (35%). The use of PLP with cisplatin + paclitaxel also showed a greater cytotoxic profile of 55% (p<0.002). Cell death by apoptosis was not confirmed by DNA fragments in Y15 and PLP positive treatment groups. Y15 and PLP significantly enhances the cytotoxic profile of cisplatin, paclitaxel in resistant OVCAR-3 cells suggesting that targeting FAK activity through the inhibition of Y397 site and the use of PLP augments resistance to paclitaxel and cisplatin. However further studies are needed to determine the mechanistic pathway of Y15 and Pyridoxal 5′Phosphate induce cytotoxicity. Citation Format: Monique P. Reboe, Terry-ann Waite, Arkene S. Levy, Sivanesan Dhandayuthapani, Appu Rathinavelu. Y15 and Pyridoxal 5′ Phosphate enhances the cytotoxic profile of Cisplatin and Paclitaxel in platinum resistant ovarian cancer cells. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 1751. doi:10.1158/1538-7445.AM2015-1751

The annual Eastern Canadian Colorectal Cancer Consensus Conference was held in Halifax, Nova Scotia, October 20-22, 2011. Health care professionals involved in the care of patients with colorectal cancer participated in presentation and discussion sessions for the purposes of developing the recommendations presented here. This consensus statement addresses current issues in the management of rectal cancer, including pathology reporting, neoadjuvant systemic and radiation therapy, surgical techniques, and palliative care of rectal cancer patients. Other topics discussed include multidisciplinary cancer conferences, treatment of gastrointestinal stromal tumours and pancreatic neuroendocrine tumours, the use of folfirinox in pancreatic cancer, and treatment of stage ii colon cancer.

We tested the association between specific values and beliefs, cultural representations of HIV/AIDS and high-risk sexual and drug-use behaviours in the Former Soviet Republic of Georgia. We questioned 2880 adolescents aged 14-17 in Georgia using a three-stage stratified probability sample. Respondents were from nine regions sampled across the country. Participants completed an inventory measuring demographic variables and openness to change values, fatalism, specific societal beliefs, sexual contact, drug taking and condom use. Sexual intercourse was reported by 40% of males, 3% of females; drug injection by 4% males, 1% of females. Those living in urban locations were more likely to report having had sex, have used condoms regularly, and tried non-injection drugs. In multivariate logistic analyses, openness to change values were associated with having had sex, and fatalistic beliefs with having had sex, irregular condom use and drug injection. Particular beliefs (e.g. that "mainly gay people get AIDS") were associated with irregular condom use and a greater likelihood of drug injection. Location and specific values and beliefs are important risk factors for increased sexual risk-taking and drug use amongst adolescents in Georgia.

Soil Science Society of America JournalVolume 70, Issue 3 p. 1038-1038 Soil analysis Letter to the Editor on “Using the Berthelot Method for Nitrite and Nitrate Analysis” Gerald K. Sims, Corresponding Author Gerald K. Sims [email protected] USDA-ARS, 1102 South Goodwin Avenue, Urbana, IL, 61801[email protected]Search for more papers by this author Gerald K. Sims, Corresponding Author Gerald K. Sims [email protected] USDA-ARS, 1102 South Goodwin Avenue, Urbana, IL, 61801[email protected]Search for more papers by this author First published: 01 May 2006 https://doi.org/10.2136/sssaj2005.0408lCitations: 4Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article.Citing Literature Volume70, Issue3May 2006Pages 1038-1038 RelatedInformation

Coarse earthenware production at the Dutch East India Company (VOC) Cape settlement began shortly after the Company established its mercantile entrepot on the shores of Table Bay in 1652. Made by European Company potters, these vessels reproduced the forms of the homeland in the raw materials of the colony. A history of VOC pottery manufacture and a typological examination of the products illustrates how the global movements of mercantile capitalism combined with the local circumstances of the Cape settlement to create a material form reminiscent of Europe, but purely colonial in the dynamics of its production and use.

SYNOPSISPlasmodium clelandi sp. n. is described from Varanus cepedianus of Mannar District, Ceylon. The earliest asexual stages were seen as a chromatin dot. Trophozoites have a vacuole with chromatin material spread around its periphery. The trophozoites divide and mature to form the schizont.The maximum number of merozoites observed in a schizont was 8. Pigment was scanty and sometimes absent. The gametocytes had a characteristic elongate form and tend to encircle the host cell nucleus.