Gothia Innovation (Sweden)

Article Jason Philip Coy, The Devil’s Art. Divination and Discipline in Early Modern Germany. (Studies in Early Modern German History.) Charlottesville, VA, University of Virginia Press 2020 was published on December 1, 2021 in the journal Historische Zeitschrift (volume 313, issue 3).

Abstract Introduction: Standard-risk medulloblastoma (SR-MB; 50-60% of patients) is currently defined by the absence of high-risk (e.g. metastatic disease, large-cell/anaplastic histology, MYC amplification) disease features. 75-85% survival rates are achieved, however the identification and validation of novel prognostic biomarkers will be essential to improve risk-adapted therapies, aimed at increased survival and reduced treatment-related late-effects. Experimental procedures: We undertook comprehensive analysis of the pan-European HIT-SIOP-PNET4 prospective clinical trial (2001-2006; age 4-21 years at diagnosis), encompassing central clinical and radiological review, and annotation of molecular pathological features to the WHO (2016) classification. Methods were developed and/or adapted to assess methylation-dependent molecular subgroup (MassArray), copy number aberrations (molecular inversion probe array) and mutational status in scant archival material previously refractory to analysis (n=136). Independent prognostic markers/predictive models for non-WNT/non-SHH patients (n=91) were identified by multivariate analyses, and validated in a representative independent cohort (n=70). Results: WNT (n=28; 21%) and Group 4 (n=76; 56%) tumors were enriched in SR-MB compared to published disease-wide estimates. Favorable-risk WNT disease was confirmed in patients <16.0 years at diagnosis. All events in SHH (4 of 17) occurred in tumors with TP53 mutation and/or chr17p loss. In non-WNT/non-SHH tumors, a novel whole chromosomal aberration (WCA) phenotype characterized by chr7 gain, chr8 loss, and/or chr11 loss, was identified in 42% of patients (38 of 91). This phenotype predicted an excellent prognosis (100% 5-year PFS) and its incorporation into novel survival models out-performed current risk-stratification schemes for SR-MB. Conclusion: A favorable-risk WCA phenotype identifies a large proportion (42%) of non-WNT/non-SHH SR-MB patients for whom therapy de-escalation should be considered in future biomarker-driven risk-adapted clinical trials; remaining patients (58%; 68% 5-year PFS) might benefit from more intensive and/or novel therapies. Citation Format: Tobias Goschzik, Ed C. Schwalbe, Debbie Hicks, Dominique Figarella-Branger, Francois Doz, Stefan Rutkowski, Goran Gustafsson, Birgitta Lannering, Torsten Pietsch, Steve C. Clifford. A whole chromosome aberration phenotype in non-WNT/non-SHH tumors predicts outcome within standard-risk medulloblastomas from the HIT-SIOP-PNET4 clinical trial [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr LB-324.

This is the first part of a two-paper series and presents the modeling methodology for all of the main components of a typical wind power plant for power system transient studies. The models developed are intended for investigation of the temporary overvoltages, switching overvoltages, and lightning overvoltages. The component models developed include the high-frequency models of the vacuum and SF6 circuit breakers, three core cables for the collector grid, and quad core cables for the wind turbine tower, turbine transformer, doubly fed asynchronous generator, and surge arrester. The models developed are wideband in nature and can be used for all studies, except the transformer model which requires two variations for the low–mid frequency range and mid–high frequency range. Detailed user-defined models developed for both vacuum and SF6 circuit breakers take account of the restrikes, reignitions, prestrikes, low-frequency high-current interruption, and high-frequency low-current interruption. The generator and transformer transient models include a representation of the various high-frequency capacitive couplings. The success criteria for each individual component model are discussed, and the model performance is validated against these criteria.

This paper presents a voltage-source-converter (VSC)-FfVDC-supplied industrial system with onsite generation where the VSC-HVDC and generator are taking part in the voltage and frequency control. The reason for using a frequency controller in the converter is to increase the ridethrough capability of the VSC-HVDC-supplied industrial system by exploiting the inertia energy of rotating masses in case of voltage disturbances. The investigation is performed using the PSCAD/EMTDC program and the dynamic performance of the system is evaluated during grid faults and load changes. Three comparisons are done to analyze the system response when the inverter uses different frequency-control strategies, the impact on the system when the turbine operates in different modes, and the VSC-HVDC's ability to mitigate voltage dips from the grid. Simulation results show that the use of a VSC-HVDC for feeding industrial plants can mitigate voltage dips in the grid. Different frequency-control strategies have different responses on the system. The best frequency response is achieved when the turbine is also equipped with a frequency controller.

Branchmark, P. I.; Ekholm, R.; Lindstrom, J.; Albrektsson, F.; Lundborg, G.; Lundskog, J.; M, L. Author Information